Maher, M. A. published the artcileNifedipine alone or combined with sildenafil citrate for management of threatened preterm labour: a randomised trial, Category: pyridine-derivatives, the main research area is nifedipine sildenafil citrate human preterm labor; Nifedipine; prematurity; sildenafil citrate; threatened preterm labour; tocolytic therapy.
To study the tocolytic action of nifedipine combined with sildenafil citrate (SC) and if the combination is superior to nifedipine alone in inhibiting threatened preterm labour (PTL). Prospective randomised study. An Egyptian university hospital. Women with threatened PTL who received either nifedipine with SC or nifedipine alone. Patients were randomly allocated to receive either (1) nifedipine 20 mg orally (stat dose), followed by 10 mg orally every 6-8 h at the same time as vaginal administration of SC (25 mg at 8-hourly intervals) or (2) nifedipine alone. Medications were continued for 48-72 h. The percentage of women who remained undelivered during hospitalisation. From Jan. 2015 to Nov. 2016, 239 women were randomised. The baseline characteristics of participants were similar. Nifedipine combined with SC was associated with more women remaining undelivered (81.8 vs. 68.6%; P = 0.018) during hospitalisation. Regarding secondary outcomes, the addition of SC was also associated with fewer deliveries within 7 days of admission (9.1 vs. 20.3%; P = 0.014), prolonged latency (29 vs. 7 days; P = 0.002), fewer admissions to neonatal intensive care units (31.4 vs. 44.1%; P = 0.043), fewer very preterm deliveries (from 28 to <32 wk, 20.7 vs. 38.1%; P = 0.043), and increased neonatal birthweight (1900 vs. 1500 g; P = 0.018). Vaginal SC combined with nifedipine is an effective option for tocolytic therapy during threatened PTL. Vaginal SC enhances the tocolytic effect of nifedipine. BJOG published new progress about Birth weight. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Category: pyridine-derivatives.