Zn-promoted regio- and sequence-selective one-pot joining reactions of three components: vinylpyridines, alkyl iodides, and carbonyl compounds (or nitriles) was written by Mineyama, Kenji;Maekawa, Hirofumi;Kohsaka, Akihiro;Yamamoto, Yoshimasa;Nishiguchi, Ikuzo. And the article was included in Tetrahedron in 2009.Application of 27876-24-0 This article mentions the following:
Addition of alkyl iodides into the solution containing 2-(or 4-)vinylpyridine and carbonyl compounds in the presence of Zn-powder (99.9%) in acetonitrile under refluxing brought about regio- and sequence-selective joining reaction of three components to give the corresponding (2-hydroxyethyl)pyridines e.g. I, in good to moderate yields. On the other hand, 2-(2- or 4-pyridyl)ethyl alkyl ketones e.g. II, were obtained from the similar joining reaction of three components by addition of alkyl iodides into the solution of 2-(or 4-)vinylpyridine, and nitriles in toluene containing Zn-powder (99.9%) under the similar reaction conditions. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Application of 27876-24-0).
4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 27876-24-0