Flow technol. for telescoped generation, lithiation and electrophilic (C3) functionalization of highly strained 1-azabicyclo[1.1.0]butanes was written by Musci, Pantaleo;von Keutz, Timo;Belaj, Ferdinand;Degennaro, Leonardo;Cantillo, David;Kappe, C. Oliver;Luisi, Renzo. And the article was included in Angewandte Chemie, International Edition in 2021.Name: Phenyl(pyridin-2-yl)methanone This article mentions the following:
Strained compounds are privileged moieties in modern synthesis. In this context, 1-azabicyclo[1.1.0]butanes are appealing structural motifs that can be employed as click reagents or precursors to azetidines. We herein report the first telescoped continuous flow protocol for the generation, lithiation, and electrophilic trapping of 1-azabicyclo[1.1.0]butanes. The flow method allows for exquisite control of the reaction parameters, and the process operates at higher temperatures and safer conditions with respect to batch mode. The efficiency of this intramol. cyclization/C3-lithiation/electrophilic quenching flow sequence is documented with more than 20 examples. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Name: Phenyl(pyridin-2-yl)methanone).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Name: Phenyl(pyridin-2-yl)methanone