Design of potent IGF1-R inhibitors related to bis-azaindoles was written by Nemecek, Conception;Metz, William A.;Wentzler, Sylvie;Ding, Fa-Xiang;Venot, Corinne;Souaille, Catherine;Dagallier, Anne;Maignan, Sebastien;Guilloteau, Jean-Pierre;Bernard, Francois;Henry, Alain;Grapinet, Sandrine;Lesuisse, Dominique. And the article was included in Chemical Biology & Drug Design in 2010.HPLC of Formula: 882033-66-1 This article mentions the following:
From an azaindole lead (I), identified in high throughput screen, a series of potent bis-azaindole inhibitors of IGF1-R have been synthesized using rational drug design and SAR based on an in silico binding mode hypothesis. Although the resulting compounds produced the expected improved potency, the model was not validated by the co-crystallization experiments with IGF1-R. General synthetic schemes for preparing the compounds tested are given in the paper. In the experiment, the researchers used many compounds, for example, 4-Chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine (cas: 882033-66-1HPLC of Formula: 882033-66-1).
4-Chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine (cas: 882033-66-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.HPLC of Formula: 882033-66-1