Electric Literature of 118175-10-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 118175-10-3 as follows.
(Reference Example 4) 2-Hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine (5.0 g (23.7 mmol)) was dissolved in dichloromethane (40 ml), and thionyl chloride (4.23 g (35.6 mmol)) was added dropwise thereto so that the temperature did not exceed 25C. Following stirring at room temperature, disappearance of the raw materials was confirmed by TLC, and 2-chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine (6.23 g) was obtained by concentrating under a reduced pressure (yield: 99.0%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,118175-10-3, its application will become more common.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP1775292; (2007); A1;,
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