Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 913839-73-3, name is 2-(6-(Trifluoromethyl)pyridin-3-yl)acetic acid. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(6-(Trifluoromethyl)pyridin-3-yl)acetic acid
56C. Preparation of N’-(5-bromo-4-(4-chlorophenyl)pyridin-2-yl)-2-(6-(trifluoromethyl)pyridin-3-yl)acetohydrazide; To a suspension of 5-bromo-4-(4-chlorophenyl)-2-hydrazinylpyridine (37 mg, 0.12 mmol), 2-(6-(trifluoromethyl)pyridin-3-yl)acetic acid (26 mg, 0.12 mmol) and bromotripyrrolidinophosphonium hexafluorophosphate (PyBop, 70 mg, 0.13 mmol) in CH3CN (1.0 mL) was added (i-Pr)2EtN (32 mg, 0.25 mmol) at 20° C. The reaction mixture was stirred at 20° C. under argon for 15 h, then concentrated in vacuo. The residue was dissolved in EtOAc (15 mL). The organic solution was successively washed with saturated aqueous NaHCO3 (5 mL) and saturated aqueous NaCl (5 mL), dried over MgSO4, filtered and concentrated in vacuo. The residue was purified using reverse phase preparative HPLC (Conditions: Phemomenex Luna 5mu C18 30.x.75 mm; Eluted with 0percent to 100percent B, 10 min gradient, 100percent B hold for 2 min, (A=90percent H2O, 10percent CH3CN, 0.1percent trifluoroacetic acid and B=10percent H2O, 90percent CH3CN, 0.1percent trifluoroacetic acid); Flow rate at 40 mL/min, UV detection at 220 nm), followed by basification with 1N aqueous NaOH to pH 12 and extraction with EtOAc to afford 54 mg (92percent) of the title compound as a white solid. LC/MS (method B): retention time=1.91 min, [M+H]+=487.0.
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Reference:
Patent; Sun, Chongqing; Huang, Yanting; Sitkoff, Doree F.; Lee, Taekyu; Ewing, William; US2006/287324; (2006); A1;,
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