Reference of 408365-87-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.408365-87-7, name is Ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate, molecular formula is C14H20N2O4, molecular weight is 280.32, as common compound, the synthetic route is as follows.
2C. (6-amino-pyridin-2-yl) acetic acid ethyl ester; To a solution of title compound 2B, (6-te;’t-butoxycarbonylamino-pyridin-2-yl) acetic acid ethyl ester, (1.38 g, 4.92 mmol) in DCM (20 ml) is added 4M HCl in dioxane (4 eq, 19.7 mmol) and the mixture is stirred for 4 h at room temperature. A further 4 eq of 4M HCl in dioxane are added and the mixture is left to stir for 16 h. The reaction mixture is concentrated in vacuo to give the title compound (1.20 g, > 100% ~14% starting material remained). LC/MS: 75% MH+, m/z 181, Rt = 0.68 mins. The product is used crude without further purification.
The chemical industry reduces the impact on the environment during synthesis 408365-87-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; EVOTEC AG; WO2006/50908; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem