New downstream synthetic route of 65977-55-1

Statistics shows that 65977-55-1 is playing an increasingly important role. we look forward to future research findings about 5-Chlorothieno[3,2-b]pyridine.

Electric Literature of 65977-55-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.65977-55-1, name is 5-Chlorothieno[3,2-b]pyridine, molecular formula is C7H4ClNS, molecular weight is 169.63, as common compound, the synthetic route is as follows.

1.00 g of 5-Chloro-thieno[3,2-b]pyridine (5.91 mmol), 497 mg of sodium bicarbonate (5.91 mmol), 1.54 g of potassium hydrogenphosphate (8.87 mmol) and 1.07 g of magnesium sulfate (8.87 mmol) are placed in a flask with 50 ml of chloroform. The reaction mixture is stirred under reflux for 30 min. 0.55ml of Bromine (10.82 mmol) is added and stirred under reflux overnight. 0.55 ml of Additional EPO bromine (10.82 mmol) is added and stirred under reflux for 1 day. The reaction mixture is cooled to room temperature and water and CH2Cl2 are added. Organic layer is separated. The water layer is adjusted to pH = 14 with 5N NaOH and extracted with CH2Cl2. All organic layers are combined together and dried over Na2SO4 and evaporated. The crude product is applied onto a silica-gel chromatography column (Hexane: AcOEt = 5:1) to give 796 mg of the title compound (549^.1H-NMR(CDCI3): 8.12(d, IH, J=7.9Hz), 7.81(s, IH), 7.36(d, IH, J=7.9Hz) ppm.

Statistics shows that 65977-55-1 is playing an increasingly important role. we look forward to future research findings about 5-Chlorothieno[3,2-b]pyridine.

Reference:
Patent; ELI LILLY AND COMPANY; WO2006/107784; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem