Adding a certain compound to certain chemical reactions, such as: 72716-86-0, 2-Methoxyisonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 72716-86-0, blongs to pyridine-derivatives compound. SDS of cas: 72716-86-0
(ii) A mixture of 2-methoxy-4-cyanopyridine (57.2 g), semicarbazide hydrochloride (71.24 g), sodium acetate (69.86 g), ethanol (1200 ml) and water (370 ml) was hydrogenated at 344 kPa using Raney nickel catalyst (1.0 g). The mixture was evaporated to a volume of 450 ml, water (900 ml) was added and the mixture was allowed to stand at 0 overnight. The mixture was filtered and the solid was washed with water and was dissolved in 10% hydrochloric acid (950 ml). Formaldehyde solution (36% w/v, 420 ml) was added and the mixture was warmed for 30 minutes, allowed to cool and was cooled to a solution of sodium acetate (280 g) in water (840 ml). The mixture was extracted with ether (3*500 ml) and the combined extracts were successively washed with aqueous potassium carbonate and water and were dried and evaporated to give 2-methoxypyridine-4-carboxyaldehyde (20.53 g, 35%) m.p. 33-35. A sample recrystallized from petroleum ether had m.p. 33-36.
The synthetic route of 72716-86-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Smith Kline & French Laboratories Limited; US4234588; (1980); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem