New learning discoveries about 223463-13-6

Application of 223463-13-6, Adding some certain compound to certain chemical reactions, such as: 223463-13-6, name is 5-Bromo-2-iodopyridine,molecular formula is C5H3BrIN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 223463-13-6.

Example 1 : Preparation of 5-bromo-pyridine-2-sulfonic acid picolyl amideAt O0C, a solution of isopropylmagnesiumchoride (2 M in tetrahydrofuran, 1.1 equivalents (eq.)) was slowly added to 80 mmol of 3-bromo-6-iodo-pyridine in 80 ml of tetrahydrofuran, maintaining the temperature between 0 and 1 O0C. After stirring for 1 h at about 2O0C, the solution was cooled to (-4O)0C. Then, 2.5 eq. of SO2 was added under intense cooling to maintain a temperature of (-4O)0C. After 30 minutes at this temperature, 1.1 eq. of SO2CI2 was added carefully. Then, the reaction mixture was warmed to O0C. After 30 minutes stirring, 10 % aqueous hydrochloric acid was added carefully. Then, the crude reaction mixture was extracted with 100 ml of diethyl ether three times. The combined organic phases were washed with saturated aqueous sodium chloride and then dried over sodium sulfate. The solvent was removed and the crude sulfochloride was dissolved in 40 ml of acetonitrile.Meanwhile, 1.1 equivalent of picolylamine and 1.1 equivalent of triethylamine were dissolved in 50 ml of methylcyanide and cooled to O0C. The crude sulfochloride in methylcyanide was added via a dropping funnel maintaining the temperature below 100C. The solution was warmed to about 2O0C and stirred over night. Then, the precipitated solid was filtered off and washed with 30 ml of water. The product obtained was an off-white solid. Yield: 20.0 g (82 %); m.p.: 1560C.

According to the analysis of related databases, 223463-13-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BASF AKTIENGESELLSCHAFT; WO2007/93599; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem