Synthesis of 1,8-Naphthyridines and Their Application in the Development of Anionic Fluorogenic Chemosensors was written by Nicoleti, Celso R.;Garcia, Diogo N.;Silva, Luiz E.;Begnini, Ieda M.;Rebelo, Ricardo A.;Joussef, Antonio C.;Machado, Vanderlei G.. And the article was included in Journal of Fluorescence in 2012.Reference of 1075-62-3 This article mentions the following:
Two 1,8-naphthyridines were synthesized and are fluorescent in solution These compounds were studied in the presence of Cu+ and Cu2+ ions and it was verified that the metal causes the quenching of their fluorescence emission, due to the formation of complexes between the naphthyridine and the metal. A displacement assay was carried out in a DMSO-water mixture with the addition of various anions to the solutions of the complexes, and these systems have a high capacity to selectively detect cyanide. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Reference of 1075-62-3).
N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of 1075-62-3