[2+2] Halogen-bonded boxes employing azobenzenes was written by Nieland, Esther;Topornicki, Thomas;Kunde, Tom;Schmidt, Bernd M.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:
Herein, we report the synthesis and crystal structures of three [2+2] supramol. boxes assembled by halogen bonding [e.g., I2.II2]. The discrete, two-dimensional boxes with a length of 25-30 Å are based on rigid u-shaped halogen acceptors paired with highly fluorinated, azobenzenes bearing halogen bond donors. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 3,5-Dimethylpyridine 1-oxide