Niu, Nana published the artcileDesign and Synthesis of Tetrandrine Derivatives as Potential Anti-tumor Agents Against A549 Cell Lines, Category: pyridine-derivatives, the publication is ChemistrySelect (2019), 4(1), 196-201, database is CAplus.
Tetrandrine was converted to 5-bromotetrandrine using a mild oxidative system (DMSO/HBr). Suzuki-Miyaura and Sonogashira cross-coupling reactions were then employed to yield a set of 5-substituted tetrandrine derivatives I (R = 5-formylfuran-2-yl, pyrimidin-5-yl, 2-cyclopropylethynyl, etc.). Their antiproliferative activities against A549 cell lines in vitro were evaluated using the MTT assay. Most of the compounds were found to possess significant inhibitory activities and compound I (R = 2-methoxypyrimidin-5-yl) (A) had the highest (IC50 = 3.04 μM). Further studies on the mechanism demonstrated by (A) showed that it promotes apoptosis of A549 cells in a dose-dependent manner and reduces the mitochondrial membrane potential. Western blot results showed that the compound up-regulated the levels of Bax protein and down-regulated the level of Bcl-2 protein. Compared to the control group, the expression of cleaved-caspase 3 and cleaved-PARP in cells was significantly increased.
ChemistrySelect published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C6H8BNO3, Category: pyridine-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem