Gram-Scale Synthesis of Amines Bearing a gem-Difluorocyclopropane Moiety was written by Nosik, Pavel S.;Gerasov, Andrii O.;Boiko, Rodion O.;Rusanov, Eduard;Ryabukhin, Sergey V.;Grygorenko, Oleksandr O.;Volochnyuk, Dmitriy M.. And the article was included in Advanced Synthesis & Catalysis in 2017.Synthetic Route of C10H17NO2 This article mentions the following:
The synthesis of monocyclic, spirocyclic and fused bicyclic secondary amines bearing a gem-difluorocyclopropane moiety via difluorocyclopropanation of unsaturated N-Boc derivatives using the trifluoromethyl(trimethyl)silane/sodium iodide [CF3SiMe3-NaI] system is described. The relative order of the substrate reactivity is established. It is shown that for the reactive alkenes the standard reaction conditions can be used, whereas for the substrates with low reactivity, slow addition of the Ruppert-Prakash reagent is necessary. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Synthetic Route of C10H17NO2).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C10H17NO2