Odani, Noritaka published the artcileDetermining the effect of photodegradation on film coated nifedipine tablets with terahertz based coating thickness measurements, Related Products of pyridine-derivatives, the main research area is nifedipine film coating thickness photodegradation TOF MLR; Photostability; Process analytical technology; Tablet coating; Terahertz spectroscopy.
Film coating of nifedipine tablets is commonly performed to reduce photo-degradation The coating thickness of these tablets is a primary dictating factor of photo-stability. Terahertz spectroscopy enables accurate measurement of coating thickness. This study identifies a method to determine an end-point of a photo-protective coating process by using coating thickness measurements from terahertz time of flight spectroscopy (THz-TOF). For this method, nifedipine tablets, at different coating thicknesses, were placed in a photostability chamber. The illumination conditions of the coated tablets were adjusted based on the time duration of these tablets inside the chamber. A multiple linear regression model was developed with the coating thickness estimates from THz-TOF and illumination conditions information to predict the amount of drug remaining after photo-degradation (percent label claim). The prediction error of this model was 1.03% label claim in the range of 88.4-100.6% label claim. According to this model, acceptable levels of photo-protection in illumination conditions of up to approx. 700,000 lx hours was achieved at the end of the coating process (approx. 50 ^fmm coating thickness) performed in this study. These results suggest THz-TOF as a viable process anal. technol. tool for process understanding and end-point determination of a photo-protective coating process.
European Journal of Pharmaceutics and Biopharmaceutics published new progress about Far-IR radiation. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Related Products of pyridine-derivatives.