Ohanyan, Vahagn published the artcileMyocardial Blood Flow Control by Oxygen Sensing Vascular Kvbeta Proteins, Related Products of pyridine-derivatives, the main research area is myocardial blood flow control oxygen sensing vascular Kvbeta protein; aldo-keto reductases; coronary circulation; ion channels; physiology; potassium channels.
Voltage-gated potassium (Kv) channels in vascular smooth muscle are essential for coupling myocardial blood flow (MBF) with the metabolic demand of the heart. These channels consist of a transmembrane pore domain that associates with auxiliary Kvbeta (voltage-gated potassium channel beta)1 and Kvbeta2 proteins, which differentially regulate Kv function in excitable cells. Nonetheless, the physiol. role of Kvbeta proteins in regulating vascular tone and metabolic hyperemia in the heart remains unknown. To test the hypothesis that Kvbeta proteins confer oxygen sensitivity to vascular tone and are required for regulating blood flow in the heart. Mice lacking Kvbeta2 subunits exhibited suppressed MBF, impaired cardiac contractile performance, and failed to maintain elevated arterial blood pressure in response to catecholamine-induced stress. In contrast, ablation of Kvbeta1.1 reduced cardiac workload, modestly elevated MBF, and preserved cardiac function during stress compared with wild-type mice. Coronary arteries isolated from Kvbeta2-/-, but not Kvbeta1.1-/-, mice had severely blunted vasodilation to hypoxia when compared with arteries from wild-type mice. Moreover, vasodilation of small diameter coronary and mesenteric arteries due to L-lactate, a biochem. marker of reduced tissue oxygenation and anaerobic metabolism, was significantly attenuated in vessels isolated from Kvbeta2-/- mice. Inducible enhancement of the Kvbeta1:Kvbeta2 ratio in Kv1 channels of arterial smooth muscle abolished L-lactate-induced vasodilation and suppressed the relationship between MBF and cardiac workload. The Kvbeta proteins differentially regulate vascular tone and MBF, whereby Kvbeta2 promotes, and Kvbeta1.1 inhibits oxygen-dependent vasodilation and augments blood flow upon heightened metabolic demand.
Circulation Research published new progress about Blood pressure. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Related Products of pyridine-derivatives.