Cyclometallated compounds XIV. Kinetic versus thermodynamic control in the reversible cyclopalladation of 2-(2-naphthyloxy)pyridine was written by O’Keefe, Brendan J.;Steel, Peter J.. And the article was included in Inorganic Chemistry Communications in 1999.HPLC of Formula: 4783-68-0 This article mentions the following:
Reaction of 2-(2-naphthyloxy)pyridine with palladium acetate, in acetic acid at room temperature, gives, selectively, the kinetically controlled regioisomer from cyclopalladation in the 1-position, whereas, under reflux, the thermodynamically more stable 3-substituted isomer is exclusively formed. Furthermore, the 1-substituted isomer readily interconverts to the 3-substituted isomer on heating, indicating reversibility of the C-H bond-breaking step. That this is a general phenomenon is demonstrated by deuterium labeling experiments with related ligands. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0HPLC of Formula: 4783-68-0).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.HPLC of Formula: 4783-68-0