Pyridine-derivatives

4-Dimensional observation ER-mitochondria interaction in living cells under nanoscopy by a stable pyridium salt as biosensor was written by Zhu, Fenfang;Yang, Zhenghui;Wang, Fei;Li, Dandan;Cao, Hongzhi;Tian, Yupeng;Tian, Xiaohe. And the article was included in Sensors and Actuators, B: Chemical in 2020.Reference of 65350-59-6 This article mentions the following:

Intracellular membrane-bounded organelles are phys. associated and play critical roles in many physiol. processes. However, real-time monitoring of their interaction at the nanoscale in three-dimension (xyz-t or 4D imaging) remains considerable difficulties due to limitations of the current super-resolution probe toolbox. Here, we developed a novel cell-permeable pyridium salt derivative (TpsPym) with red-emission and large Stock-shift. Interestingly, TpsPym demonstrated a high specificity to mitochondria and endoplasmic reticulum (ER) with different fluorescent intensity. This offered the possibility to utilize this probe to label dual-organelles (ER-mitochondria) under stimulated emission depletion nanoscopy (STED). We successfully monitored the dynamic interactions in real-time between mitochondria and ER in three dimension during starvation-induced autophagy. It suggested ER-mitochondria contacting area might play an essential factor during autophagic cell death (ACD). Our study not only expanding the nanoscopic probe kit but also provide new understanding for ER-mitochondrial interaction at the nanoscale during correlated physiol. conditions. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Reference of 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Reference of 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium-Catalyzed Selective Mono- and Diamination of Arenes with Single Directing Site “On Water” was written by Ali, Ashif Md;Yao, Xiayin;Li, Guigen;Lu, Hongjian. And the article was included in Organic Letters in 2016.Recommanded Product: 4373-61-9 This article mentions the following:

A Rh(III)-catalyzed selective C-H amination of 2-phenylpyridine derivatives is reported. With pyridine as a directing group, the reaction has high mono- or diamination selectivity, and a wide range of effective substrates, including electron-deficient and -rich aryl azides. Water helps to promote C-H activation, and the concept of a water-promoted rollover mechanism is postulated for the diamination step. The reactions were conducted using a Schlenk flask and proceeded smoothly “on water” under atm. conditions with nitrogen gas as the only byproduct. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Recommanded Product: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mild C-H/C-C Activation by Z-Selective Cobalt Catalysis was written by Zell, Daniel;Bu, Qingqing;Feldt, Milica;Ackermann, Lutz. And the article was included in Angewandte Chemie, International Edition in 2016.Category: pyridine-derivatives This article mentions the following:

Cationic cobalt complexes enable unprecedented cobalt-catalyzed C-H/C-C functionalizations with unique selectivity features. The versatile cobalt catalyst proved broadly applicable, enabled efficient C-H/C-C cleavage at room temperature, and delivered Z-alkenes, e.g., I, with excellent diastereocontrol. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Category: pyridine-derivatives).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of Pyridine-N-Oxides with Tertiary sp²-N-Nucleophiles: An Efficient Synthesis of Precursors for N-(Pyrid-2-yl)-Substituted N-Heterocyclic Carbenes was written by Bugaenko, Dmitry I.;Yurovskaya, Marina A.;Karchava, Alexander V.. And the article was included in Advanced Synthesis & Catalysis in 2020.Related Products of 59718-84-2 This article mentions the following:

N-(Pyrid-2-yl)-substituted azolium and pyridinium salts, precursors for hybrid NHC-containing ligands, were obtained with excellent regioselectivity, employing a deoxygenative CH-functionalization of pyridine-N-oxides with substituted imidazoles, thiazoles, and pyridine. Unlike the traditional S_NAr-based methods, this approach provides high yields for substrates bearing substituents of different electronic nature. The utility of azolium and pyridinium salts thus prepared was also highlighted by the synthesis of pyridyl-substituted imidazolyl-2-thione, benzodiazepine as well as 2-aminopyridines. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2Related Products of 59718-84-2).

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 59718-84-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The first (tripyrrinato)nickel(II) complexes, TrpyNiX with X = Cl, Br, I: synthesis, structures and solvent coordination was written by Broering, Martin;Prikhodovski, Serguei;Brandt, Carsten D.. And the article was included in Journal of the Chemical Society, Dalton Transactions in 2002.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

A first series of Ni(II) complexes I (X = Cl, L = H₂O; X = Br, I, X = null) of the new tripyrrolic ligand 2,15-dimethyl-3,4,8,9,13,14-hexaethyltripyrrin was prepared and characterized by spectroscopic and structural means. The coordination geometry found for the four-coordinate, paramagnetic bromo- and iodo-derivatives in the solid state can best be described as distorted trigonal-bipyramidal with one ligand missing in the trigonal plane. For the chloro derivative, this empty site is occupied in the crystal by a H₂O ligand. As ¹H NMR studies on the paramagnetic TrpyNiCl reveal an equilibrium exists between the four- and five-coordinate form with solvent, but not a six-coordinate form, and for pyridine-N-oxide as the fifth ligand, thermodn. data of the ligand association could be obtained by a temperature dependent NMR titration study. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Safety of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pentamethylcyclopentadienyl rhodium(III)-chiral disulfonate hybrid catalysis for enantioselective C-H bond functionalization was written by Satake, Shun;Kurihara, Takumaru;Nishikawa, Keisuke;Mochizuki, Takuya;Hatano, Manabu;Ishihara, Kazuaki;Yoshino, Tatsuhiko;Matsunaga, Shigeki. And the article was included in Nature Catalysis in 2018.Application of 4373-61-9 This article mentions the following:

Here, a hybrid strategy for inducing chirality was reported for the synthesis of [(pyridin-2-yl)phenyl]alkanones I (R¹ = H, 4-Me, 5-Me; R² = H, 4-Me, 4-Cl, etc.; R³ = Me, PhCH₂CH₂; R⁴ = Me, Et, n-Bu, etc.) via pentamethylcyclopentadienyl rhodium(III)-chiral disulfonate hybrid catalyzed C-H activation and subsequent conjugate addition of 2-phenylpyridine derivatives to α,β-unsaturated ketones in good yields and enantioselectivity (enantiomeric ratio up to 95:5). In addition to 2-phenylpyridines, the conjugate addition of 6-arylpurines proceeded with an enantiomeric ratio of up to 91:9 using [Cp*RhL_N][(R)-SPISate] to afford [(9H-purin-6-yl)phenyl]alkanones II (R⁵ = i-Pr, PhCH₂; R⁶ = H, Me, OMe, t-Bu). The results demonstrated that a chiral organic anion could efficiently control the enantioselectivity of Cp*Rh(III)-catalyzed C-H bond functionalization without a chiral Cp^x ligand. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Visible-Light-Activated Asymmetric Addition of Hydrocarbons to Pyridine-Based Ketones was written by Yu, Han;Zhan, Tangyu;Zhou, Yuqiao;Chen, Long;Liu, Xiaohua;Feng, Xiaoming. And the article was included in ACS Catalysis in 2022.Name: Phenyl(pyridin-2-yl)methanone This article mentions the following:

A combined system involving Er(III)-based chiral Lewis acid catalysis, Ir(III)-based photoredox catalysis, and bromide-radical-mediated hydrogen atom transfer was disclosed. The introduction of a bulky and nonredox chiral Lewis acid through the photoredox pathway enabled the radical addition process and inhibited the above competitive reactions. The visible-light-promoted catalytic asym. alkylation of heteroaryl-based ketones with diverse hydrocarbons (mainly benzyl) delivered a variety of congested enantioenriched tertiary alcs. (up to 97% yield, 96% enantiomeric excess (ee)). In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Name: Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Name: Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Selective Imaging of Late Endosomes with a pH-Sensitive Diazaoxatriangulene Fluorescent Probe was written by Wallabregue, Antoine;Moreau, Dimitri;Sherin, Peter;Moneva Lorente, Pau;Jarolimova, Zdenka;Bakker, Eric;Vauthey, Eric;Gruenberg, Jean;Lacour, Jerome. And the article was included in Journal of the American Chemical Society in 2016.Computed Properties of C5H6ClN This article mentions the following:

Late endosomes are a major trafficking hub in the cell at the crossroads between endocytosis, autophagy, and degradation in lysosomes. Herein is disclosed the first small mol. allowing their selective imaging and monitoring in the form of a diazaoxatriangulene fluorophore, 1a (hexadecyl side chain). The compound is prepared in three steps from a simple carbenium precursor. In nanospheres, this pH-sensitive (pK_a = 7.3), photochem. stable dye fluoresces in the red part of visible light (601 and 578 nm, acid and basic forms, resp.) with a quantum yield between 14 and 16% and an excited-state lifetime of 7.7-7.8 ns. Importantly, the protonated form 1a·H⁺ provokes a specific staining of late endosome compartments (pH 5.0-5.5) after 5 h of incubation with HeLa cells. Not surprisingly, this late endosome marking depends on the intra-organelle pH, and changing the nature of the lipophilic chain provokes a loss of selectivity. Interestingly, fixation of the fluorophore is readily achieved with paraformaldehyde, giving the possibility to image both live and fixed cells. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Computed Properties of C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Computed Properties of C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Selective Defluoroallylation of Trifluoromethylarenes was written by Luo, Chaosheng;Bandar, Jeffrey S.. And the article was included in Journal of the American Chemical Society in 2019.Quality Control of 2-Bromo-3-(trifluoromethyl)pyridine This article mentions the following:

The authors report a fluoride-initiated coupling reaction between trifluoromethylarenes and allylsilanes to access allylated α,α-difluorobenzylic compounds This method’s utility is demonstrated through a 30 mmol scale reaction, a sequential allylation/derivatization protocol and multiple examples of site-selective trifluoromethylarene allylation. Initial mechanistic studies suggest a base-induced single electron transfer pathway is responsible for the high efficiency and selectivity of this novel C-F substitution process. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Quality Control of 2-Bromo-3-(trifluoromethyl)pyridine).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of 2-Bromo-3-(trifluoromethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A study on the effect of 1-butyl-4-methylpyridinium bromide adsorption on the structural and electronic properties of B₁₂N₁₂ nano-cage was written by Ghasemi, Ashraf Sadat;Soltani, Alireza;Karimnia, Matin;Ashrafi, Fereydoun;Heidari, Fatemeh;Majidian, Mahtab. And the article was included in Journal of Molecular Liquids in 2019.Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide This article mentions the following:

In this study, adsorption of 1-butyl-4-methylpyridinium bromide (BMPB) on the B₁₂N₁₂ nano-cage have been investigated by d. functional theory (DFT) at 298.15 K. Provided data clearly indicate that the adsorption behavior of this ionic liquid on B₁₂N₁₂ nano-cage is electrostatic in nature with an energy of -0.283 eV. Furthermore, the value of dipole moment in B₁₂N₁₂ fullerene interacting with ionic liquid 1-butyl-4 methylpyridinium bromide was increased from zero to 13.64 Debye, while the dipole moment value in BMPB is 9.68 Debye. Thereupon, it is simulated to calculate the geometric optimized structure, electronic properties, NQR (NQR), NMR (NMR) studies and the natural bond orbital (NBO) anal. are conducted sep. for both B₁₂N₁₂-BMPB and BMPB. The sensitivity of B₁₂N₁₂ nano-cage to BMPB was investigated and the calculated data indicate that this nano-cage is sensitive to the presence of this ionic liquid In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem