Pyridine-derivatives

Application of 609-71-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C6H5NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To 2-hydroxynicotinic acid (3.6 mmol) in sulfuric acid (30% free S03, 2 ml) was added sodium nitrate (7.2 mmol) portionwise over 20 min. The solution was allowed to stir for 20 h at room temperature. The solution was then poured onto ice-water and the precipitate that formed was filtered off, washed with water and dried in a vacuum oven to afford a pale yellow solid (45%). (0176) ESIMS: M-l: 183 (0177) 1H NMR (300 MHz, DMSO) d 8.94 (1H, d, H-4), 8.67 (1H, d, H-6).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 609-71-2, 2-Oxo-1,2-dihydropyridine-3-carboxylic acid.

Reference:
Patent; BIONOMICS LIMITED; O’CONNOR, Sue; RATHJEN, Deborah; (55 pag.)WO2019/109150; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 823-56-3, name is 2-Fluoro-3,5-dichloropyridine, the common compound, a new synthetic route is introduced below. Quality Control of 2-Fluoro-3,5-dichloropyridine

5.00g (0.030 mol) of 3,5-dichloro-2-fluoropyridine and 5.01g of 1-(1- cyclohexen-l-yl)pyrrolidine (0.033 mol) are stirred neat together at room temperature for Ih and are left at room temperature overnight. The reaction mixture is quenched with 40ml of sulfuric acid 2M. Water is added to the reaction mixture (100 ml) which is extracted thrice with ethyl acetate (50 ml). The combined organic phases are washed with water (150 ml) and brine (100 ml). After separation, the organic phase is dried over magnesium sulfate filtered, concentrated to dryness and purified on silica gel to yield to 0.22 g of 2-[3,5-dichloro-2-pyridinyl]cyclohexanoneMass spectrum : [M+l] = 244.

The synthetic route of 823-56-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE SA; WO2006/122955; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 944401-77-8, 2-Amino-4-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 944401-77-8, blongs to pyridine-derivatives compound. SDS of cas: 944401-77-8

To a solution of 2-amino-4-fluoropyridine (75.0 g, 0.67 mol) in dry MeCN (700 mL), N-bromosuccinimide (122.8 g, 0.69 mol) was added portionwise upon stirring and cooling in an ice-water bath. The reaction mixture was stirred at r.t. for 1 h. After evaporation under reduced pressure, the residue was thoroughly washed with water (3 x 300 mL), taken up by MeCN and concentrated in vacuo yielding the title compound as an off white solid (124 g, 97 %). LCMS (ES+) RT 0.79 min, 19.0/193.0 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,944401-77-8, 2-Amino-4-fluoropyridine, and friends who are interested can also refer to it.

Reference:
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki, Peter; BRACE, Gareth, Neil; BROWN, Julien, Alistair; CALMIANO, Mark, Daniel; CHOVATIA, Praful, Tulshi; DELIGNY, Michael; GALLIMORE, Ellen, Olivia; HEER, Jag, Paul; JACKSON, Victoria, Elizabeth; KROEPLIEN, Boris; MAC COSS, Malcolm; QUINCEY, Joanna, Rachel; SABNIS, Yogesh, Anil; SWINNEN, Dominique, Louis, Leon; ZHU, Zhaoning; WO2015/86526; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 73583-37-6, 4-Bromo-2-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 73583-37-6, blongs to pyridine-derivatives compound. Product Details of 73583-37-6

A mixture of 4-bromo-2-chloropyridine (1 .92 g, 10 mmol), (4-fluoro-2- methoxyphenyl)boronic acid (1 .70 g, 10 mmol) and K3P04 (4.24 g, 20 mmol) in dioxane/water 10: 1 (20 mL) was degassed with a stream of nitrogen for 10 min. After addition of Pd(dppf)Cl2 (816 mg, 1 mmol) the reaction mixture was heated at 145C for 90 minutes in a microwave oven. It was diluted with EtOAc and washed twice with sat. aq. NaHC03 solution and once with brine. The organic layer was dried over MgS04 and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (cHex/EtOAc 100:0 to 60:40) to yield the desired product A2 as a white solid (1 .07 g, 45%). 1 H NMR (400MHz, d6-DMSO, 300K) delta 3.81 (s, 3H), 6.87 (dt, J = 8.5 Hz, J = 3.5 Hz, 1 H), 7.05 (dd, J = 1 1 .4 Hz, J = 2.5 Hz, 1 H), 7.44 (dd, J = 8.5 Hz, J = 6.8 Hz, 1 H), 7.48 (dd, J = 5.3 Hz, J = 1 .5 Hz, 1 H), 7.55 (m, 1 H), 8.38 (d, J = 5.3 Hz, 1 H). MS (ES) C12H9CIFNO requires: 237, found: 238 (M+H)+.

The synthetic route of 73583-37-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LEAD DISCOVERY CENTER GMBH; BAYER INTELLECTUAL PROPERTY GMBH; RUeHTER, Gerd; NUSSBAUMER, Peter; CHOIDAS, Axel; SCHULTZ-FADEMRECHT, Carsten; KLEBL, Bert; EICKHOFF, Jan; WO2012/117059; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 55279-29-3, 3-Aminoisonicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Example 3 [0159] 3-aminonicotinaldehyde (50 mg, 0.41 mmol) and 1 -(2-chloro-5- nitrophenyl)ethanone (82 mg, 0.41 mmol) were put into ethanol (1 ml_), and then added NaOH (0.3 mg, 0.01 mmol) at room temperature. The solution was heated to 70 C and stirred at this temperature for overnight. The reaction mixture was concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel to yield the desired product (38 mg, 33 % yield) as a white solid. 1H NMR (400 MHz, DMSO-d6): delta 9.50 (s, 1 H), 8.71 (d, J = 5.2 Hz, 1 H), 8.63 (d, J = 8.4 Hz, 1 H), 8.53 (d, J = 2.8 Hz, 1 H), 8.40-8.37 (m, 1 H), 8.16 (d, J = 8.8 Hz, 1 H), 8.04-8.02 (m, 1 H), 7.99-7.97 (m, 1 H). MS (ESI): Calcd. for Ci4H8CIN3O2: 285, found 286 (M+H)+.

The synthetic route of 55279-29-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NANT HOLDINGS IP, LLC; TAO, Chunlin; YU, Chengzhi; ARP, Forrest; WEINGARTEN, Paul; SOON-SHIONG, Patrick; WO2014/71298; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 24242-20-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 24242-20-4, name is 5-Aminopicolinic acid, molecular formula is C6H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 5-aminopyridiencarboxylic acid (16; 8.4 g, 60.8 mmol) inethanol ( 100 mL) was added SOO2 (14.5g, 120 mmol) at 0 C. The mixture was refluxed for 1 2 h. The solvent was removed and saturated Na2C03 solution was added to adjust pH=9 and fi ltrated to give a solid. Dried in vacuo to give ethyl 5-aminopicolinate ( 17; 7.5 g? 75%). M S (ESI) calcd forC8H,oN202 (m/z) 166.18.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 24242-20-4, 5-Aminopicolinic acid.

Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.; WO2011/59839; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 95897-49-7, 7-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 95897-49-7, blongs to pyridine-derivatives compound. Computed Properties of C7H6BrNO2

Example 50 : 4-(6-((2, 3-dihydro- [1,4] dioxino [2,3-b] pyridin-7-yl)amino)pyridin-3-yl)- N,N-dimethylbenzamide [0531] The title compound was prepared as described in Example 25, starting from 4-(6- amino-3-pyridyl)-N,N-dimethyl-benzamide and 7-bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine and heating at 80 C for 2 days, to give the product as a solid (29 mg, 23%). NMR (500 MHz, DMSO-rie) d ppm 2.93 – 3.02 (m, 6 H), 4.24 (dt, J=3.78, 2.21Hz, 2 H), 4.35 (dt, J=3.78, 2.21Hz, 2 H), 6.87 (d, J=8.57 Hz, 1H), 7.46 – 7.48 (m, 2 H), 7.68 – 7.71 (m, 2 H), 7.87 (d, J=2.52 Hz, 1H), 7.92 – 7.96 (m, 2 H), 8.52 (d, J=2.2l Hz, 1H), 9.21 (s, 1H). MS ES+ m/z 377 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,95897-49-7, its application will become more common.

Reference:
Patent; PETRA PHARMA CORPORATION; LINDSTROeM, Johan; PERSSON, Lars Boukharta; VIKLUND, Jenny; KESICKI, Edward A.; HICKEY, Eugene R.; DAHLGREN, Markus K.; GERASYUTO, Aleksey I.; (450 pag.)WO2019/126731; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10592-27-5, name is 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine. A new synthetic method of this compound is introduced below., COA of Formula: C7H8N2

To a solution of sulfurisocyanatidic chloride (23 mg, 0.17 mmol) in DCM (1 mL) in an ice-water bath was added a solution of Intermediate GW-17.2 (60 mg, 0.17 mmol) and DIPEA (0.06 mL, 0.33 mmol) in DCM (1 mL) and the reaction mixture was stirred for 2 min. Then a solution of 2,3-dihydro-lH-pyrrolo[2,3-b]pyridine (30 mg, 0.25 mmol) in DCM (1 mL) was added, followed by DIPEA (0.1 mL, 0.66 mmol) and the reaction mixture was stirred for 2 min. The bath was removed, the reaction mixture was stirred at rt for 2 h, concentrated, the residue was redissolved in DMF and purified by preparative HPLC to afford the title compound (9.9 mg). LC-MS retention time = 2.54 min; m/z = 517.20 [M+H]+. (Column: Phenomenex C18 2.0 X 50 mm, 3 muiotaeta particles; Mobile Phase A: 10% MeOH-90% H2O-0.1% TFA; Mobile Phase B: 90% MeOH-10% H2O-0.1% TFA; Temperature: 40 C; Gradient: 0-100% B over 4 min, then a 1-min hold at 100% B; Flow: 0.8 mL/min; Detection: UV at 220 nm).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10592-27-5, 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BENDER, John A.; GENTLES, Robert G.; PENDRI, Annapurna; WANG, Alan Xiangdong; MEANWELL, Nicholas A.; BENO, Brett R.; FRIDELL, Robert A.; BELEMA, Makonen; NGUYEN, Van N.; YANG, Zhong; WANG, Gan; KUMARAVEL, Selvakumar; THANGATHIRUPATHY, Srinivasan; BORA, Rajesh Onkardas; HOLEHATTI, Shilpa Maheshwarappa; METTU, Mallikarjuna Rao; PANDA, Manoranjan; (319 pag.)WO2016/172424; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 888721-65-1 ,Some common heterocyclic compound, 888721-65-1, molecular formula is C13H10FNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 48 N-(4-(6-Amino-1-methyl-1H-indazol-5-yloxy)-3-fluorophenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate To a 10 mL screw-cap vial is added 5-(4-amino-2-fluorophenoxy)-N-benzhydryl-1-methyl-1H-indazol-6-amine (91 mg, 208 mumol), 1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid (66.7 mg, 269.78 mumol), EDCI (90.9 mg, 466.9 mumol) and HOBt (47.7 mg, 311.3 mumol) followed by DMF (2 mL, 25.9 mmol). To the mixture is added DIPEA (90.5 muL, 518.8 mumol) and the mixture is stirred at RT for 12 hours. Additional EDCI (50 mg), HOBt (25 mg), DIPEA (0.02 mL), and 1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid (40 mg) are added and the mixture is stirred for an additional 24 hours. The reaction is diluted into EtOAc (100 mL) and washed with saturated aqueous sodium chloride (3*25 mL). The combined aqueous solution is extracted with EtOAc (1*25 mL). The combined organic (100 mL) and washed with saturated aqueous sodium chloride (3*25 mL). The combined aqueous solution is extracted with EtOAc (1*25 mL). The combined organic solution is dried over Na2SO4, filtered, and concentrated to dryness. The residue is purified on a silica gel column eluding with DCM (A) and a 10% MeOH in DCM solution (B), gradient from 100% (A) to 90%(A): 10%(B) over 60 min to give a clear wax material as the desired product (114 mg, 82% yield). MS (m/z) 667.8 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 888721-65-1, 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LI, Tiechao; POBANZ, Mark Andrew; SHIH, Chuan; WU, Zhipei; YANG, Wei Jennifer; ZHONG, Boyu; US2010/22529; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 53937-02-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53937-02-3, name is 4-Benzyloxy-2-(1H)-pyridone, molecular formula is C12H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2a 4-Benzyloxy-1 -[2-(4-hydroxymethyl-phenyl)-ethyl]-1 /-/-pyridin-2-oneA mixture of 13.0 g (64.6 mmol) 4-benzyloxy-1 /-/-pyridin-2-one, 23.7 g (90.4 mmol) [4-(2-iodo- ethyl)-phenyl]-methanol (preparation 1 b) and 63.1 g (194 mmol) cesium carbonate in 55 mL of DMF is stirred overnight at RT. The reaction mixture is heated to 700C, filtered through a pad of celite which is washed with hot DMF. The solvent is removed almost completely. After cooling to RT, MeOH is added, the precipitate is filtered, washed with EtOAc and water and is dried in vacuo at 400C (fraction A). MeOH is removed in vacuo, the residue is redissolved in DMF and purified by reverse HPLC (Zorbax stable bond, C18; water (0.1 % formic acid)/acetonitrile 95:5 to 10:90) to give fraction B, which is combined with fraction A. Yield: 10.0 g (46% of theory) ESI Mass spectrum: [M+H]+ = 336 Retention time HPLC: 3.5 min (method A).

According to the analysis of related databases, 53937-02-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/22979; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem