Pyridine-derivatives

Adding a certain compound to certain chemical reactions, such as: 100-48-1, Isonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100-48-1, blongs to pyridine-derivatives compound. COA of Formula: C6H4N2

General procedure: 0.01mol nitrile dissolved in 10 ml ethanol. After that, 0.011 mol hydroxylamine hydrochloride, 10 ml water and 1.23g sodium acetate was added as followed, stirred in room temperature for 0.5 h then refluxed in 50-60 for 8 h. The ethanol was mostly evaporated in vacuum and then the aqueous residue was extracted with CH2Cl2 three times. The combined organic layer was dried over MgSO4 and evaporated to dryness to afford the desired product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-48-1, its application will become more common.

Reference:
Article; Su, Dongshan; Duan, Haifeng; Wei, Zhonglin; Cao, Jungang; Liang, Dapeng; Lin, Yingjie; Tetrahedron Letters; vol. 54; 50; (2013); p. 6959 – 6963;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 105752-11-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105752-11-2, name is 3-Amino-4-iodopyridine, molecular formula is C5H5IN2, molecular weight is 220.0111, as common compound, the synthetic route is as follows.

2,6-dichloro-[3,4′-bipyridin]-3′-amine (i64): To a stirred solution of 4-iodopyridin-3-amine (2 g, 9.0 mmol) in 1 ,4-dioxane (84 ml_), (2,6- dichloropyridin-3-yl) boronic acid (2.4 g, 12.5 mmol) and K3P04 (5.6 g, 26.0 mmol) solution in water (28 mL) were added and the reaction was degassed with argon for 20 min. PdCI2(PPh3)2 (0.7 g, 0.99 mmol) was added and the reaction was heated in a sealed tube at 100C for 16 h. The progress of the reaction was monitored by TLC. After completion, the reaction was diluted with water and filtered. The aqueous layer was extracted with ethyl acetate. The organic layer was separated, dried over anhydrous sodium sulphate and concentrated under reduced pressure. The crude product was purified by silica gel (100:200 mesh) column chromatography using 2% methanol in dichloromethane as eluent to afford 2,6-dichloro-[3,4′-bipyridin]-3′-amine (64) (1 .08 g, Yield 51 %). 1 H NMR (400 MHz, DMSO-d6) delta 5.26 (s, 2H), 6.93 (d, J = 4.9 Hz, 1 H), 7.51 -7.68 (m, 1 H), 7.79- 7.89 (m, 2H), 8.08 (s, 1 H), MS (ESI) m/e (M+1 )+: 240.00

Statistics shows that 105752-11-2 is playing an increasingly important role. we look forward to future research findings about 3-Amino-4-iodopyridine.

Reference:
Patent; UCB BIOPHARMA SPRL; MERCIER, Joel; PROVINS, Laurent; VERMEIREN, Celine; SABNIS, Yogesh Anil; (106 pag.)WO2016/124508; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 955369-63-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.955369-63-8, name is Ethyl 2-(6-bromopyridin-2-yl)acetate, molecular formula is C9H10BrNO2, molecular weight is 244.09, as common compound, the synthetic route is as follows.

To a mixture of ethyl 2-(6-bromo-2-pyridyl)acetate (2.00 g, 8.19 mmol) in THF (10 mL), water (10 mL) and MeOH (20 mL) was added LiOH.H2O (1.03 g, 24.5 mmol). Then the reaction mixture was stirred at 20 C for 2 hours. On completion, the reaction mixture was concentrated in vacuo. The residue was acidified by 1.0 N HCl to pH = 3.0, washed with water (150 mL) and extracted with ethyl acetate (3 X 150 mL). The organic layer was dried with Na2SO4, filtered and concentrated in vacuo to give the title compound (1.70 g, 96% yield) as a yellowish solid.1H NMR (400MHz, DMSO-d6) delta = 12.63 (br. s., 1H), 7.86 – 7.71 (m, 1H), 7.59 (d, J = 8.0 Hz, 1H), 7.46 (d, J = 7.6 Hz, 1H), 3.81 (s, 2H).

Statistics shows that 955369-63-8 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-(6-bromopyridin-2-yl)acetate.

Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (215 pag.)WO2018/106636; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 55304-73-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.55304-73-9, name is 2,6-Dichloro-3-formylpyridine, molecular formula is C6H3Cl2NO, molecular weight is 176, as common compound, the synthetic route is as follows.

Example 27 c. 2-((2,6-dichloropyridin-3-yl)methylamino)-l-(l,3-dimethyl-lH- pyrazol-5-yl)ethanol2,6-Dichloronicotinaldehyde (0.964 g, 5.48 mmol), 2-amino-l -(1,3 -dimethyl- lH-pyrazol- 5-yl)ethanol (0.810 g, 5.22 mmol) and acetic acid (0.149 ml, 2.61 mmol) in methanol (10 mL) was stirred at room temperature for 20 minutes. Methanol (15 mL) was added and cooled to 00C. Sodium cyanoborohydride (0.394 g, 6.26 mmol) was added and the reaction mixture was stirred at 00C for 10 minutes. The solvent was evaporated and the residue was partitioned between dichloromethane and sat. NaHCO3 (aq). The water layer was extracted twice with dichloromethane and the combined organic layer was dried (MgSO4) and concentrated. The crude product was purified by silica column chromatography using a gradient of methanol (0 to 5%) in dichloromethane giving 1.5O g of the title compound (91 % Yield). 1H NMR (500 MHz, DMSO-J6) delta ppm 7.99 (dd, 1 H), 7.52 – 7.63 (m, 1 H), 5.90 (s, 1 H), 5.37 (dt, 1 H), 4.63 – 4.76 (m, 1 H), 3.76 – 3.86 (m, 2 H), 3.65 – 3.75 (m, 3 H), 3.17 (dt, 1 H), 2.69 – 2.87 (m, 2 H), 2.01 – 2.16 (m, 3 H). MS m/z 315, 317, 319 [M+H] +.

Statistics shows that 55304-73-9 is playing an increasingly important role. we look forward to future research findings about 2,6-Dichloro-3-formylpyridine.

Reference:
Patent; ASTRAZENECA AB; LO-ALFREDSSON, Yvonne; PAULSEN, Kim; RAKOS, Laszlo; ROTTICCI, Didier; WALDMAN, Magnus; WO2010/132015; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 2402-78-0 , The common heterocyclic compound, 2402-78-0, name is 2,6-Dichloropyridine, molecular formula is C5H3Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of n-BuLi (21.1 ml_, 33.8 mmol, 1.6 M) in THF is cooled to -78C before a solution of 2,6-dichloropyhdine (5.0 g, 33.8 mmol) in THF (36 ml_) is added dropwise over a period of 20 min. The reaction mixture is stirred at -78C for 30 min, and then iodomethane (4.79 g, 33.8 mmol) is added. The mixture is stirred for 30 min before it is quenched with sat. aq. NH4CI solution at -78C. The mixture is extracted with diethyl ether, the org. extract is dried over MgSO4, filtered and concentrated. The crude product is purified by CC on silica gel eluting with heptane:EA 19:1 to give 2,6-dichloro-4-methyl-pyridine (2.34 g) as a colourless oil containing the regio isomer 2,6-dichloro-3-methyl-pyhdine; LC-MS: tR = 0.89 min, [M+1]+ = 161.97.

The synthetic route of 2402-78-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/24905; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 19798-80-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19798-80-2, name is 4-Chloropyridin-2-amine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-chloropyridin-2-amine (3 g, 23.2 mmol) in DMSO (60 mL) was added sodium methoxide (12.6 g, 232 mmol) and the mixture was then stirred at 150 C for 3 hours then poured into ice-water. The product was extracted with EtOAc (2×100 mL), and the combined organic layers were washed with water (50 mL) and brine (50 mL), dried (Na2S04) and concentrated. The residue was purified by silica gel chromatography using a solvent system of 50% petroleum ether/EtOAc to give 4-methoxypyridin-2-amine (460 mg, 16%) as a yellow solid MS ESI calc’d for C6H8N20 [M + H]+ 125, found 125.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19798-80-2, 4-Chloropyridin-2-amine.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ANDRESEN, Brian, M.; ANTHONY, Neville, J.; MILLER, Thomas, A.; WO2014/74422; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 73027-79-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73027-79-9, name is 4,6-Dichloronicotinic acid, molecular formula is C6H3Cl2NO2, molecular weight is 192, as common compound, the synthetic route is as follows.

To a solution of 4,6-dichloropyridine-3-carboxylic acid (2.8 g, 14.58 mmol) in dry DMF (10 mL) was added triethylamine (2.24 mL, 16.04 mmol) at 0 C followed by addition of diphenylphosphoryl azide (3.45 mL, 16.04 mmol). The reaction mixture was stirred at RT for lh and poured onto a mixture of ice-water-EtOAc. The product was extracted with EtOAc (2×50 mL). The combined extracts were washed with water (50 mL), saturated solution of sodium bicarbonate (50 mL) and finally with brine solution (50 mL). The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford light yellow solid which was dissolved in dry toluene (30 mL) and heated to reflux for 2 h. Then the reaction mixture was cooled to RT and t-butanol (8.36 mL, 87.48 mmol) was added. The reaction mixture was heated at 90 C for 4 h. The reaction was monitored by TLC. After completion, the reaction mixture was concentrated under reduced pressure, water was added to the residue and product was extracted with EtOAc (2×100 mL). Removal of EtOAc under reduced pressure afforded an oily residue that was purified by column chromatography on silica gel (100-200 mesh) using 1% EtOAc-hexane system as eluent to afford tert-butyl N-(4,6-dichloro-3- pyridyl)carbamate (3.8 g) as a light yellow liquid.

Statistics shows that 73027-79-9 is playing an increasingly important role. we look forward to future research findings about 4,6-Dichloronicotinic acid.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; RAI, Roopa; CHAKRAVARTY, Sarvajit; PUJALA, Brahmam; SHINDE, Bharat Uttam; NAYAK, Anjan Kumar; CHAKLAN, Naveen; AGARWAL, Anil Kumar; RAMACHANDRAN, Sreekanth A.; PHAM, Son; WO2015/103355; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 6332-56-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6332-56-5, name is 3-Nitropyridin-2(1H)-one, molecular formula is C5H4N2O3, molecular weight is 140.1, as common compound, the synthetic route is as follows.

a)Preparation of 2-amino-3-hydroxypyridine To a solution of 2-hydroxy-3-nitropyridine (5 g, 45.4 mmol) in methanol(250 ml) was added 10% Pd/C (1 g). The mixture was flushed with argon, then hydrogen was bubbled through the solution for 10 min. and a hydrogen atmosphere was maintained at balloon pressure overnight. The mixture was filtered through celite and the celite was washed with methanol. The solvent was evaporated and chromatography of the resulting solid on silica gel (5% MeOH/CH2Cl2) gave the desired product(3.2 g, 89%). 1H NMR (CD3OD): delta 6.96 (d, 1H), 6.90 (dd, 1H), 6.77 (d, 1H).

Statistics shows that 6332-56-5 is playing an increasingly important role. we look forward to future research findings about 3-Nitropyridin-2(1H)-one.

Reference:
Patent; SmithKline Beecham Corporation; US6218539; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6231-18-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6231-18-1, name is 2,6-Dimethoxypyridine. A new synthetic method of this compound is introduced below.

To a solution of 2,6-dimethoxypyridine (10 g, 71.84 mmol) and N,N-diisopropylamine (0.50 mL, 3.59 mmol) in THF (200 mL, dist. Na) at -40C under nitrogen was added -BuLi (43.10 mL, 86.21 mmol) dropwise. The resultant solution was stirred at -40C for 5 min, and then warmed to 0 C and stirred at this temperature for a further 3 hours. The solution was then again cooled to -40 C, and triisopropylborate (24.87 mL, 107.76 mmol) was added dropwise, and the mixture stirred at r.t. for another 1 hour. Water (50 mL) was added and the solvent was removed in vacuo. To the residue was added 1M NaOH (100 mL) and the aqueous layer washed with EtOAc (2 x 100 mL). The aqueous layer was then acidified to pH 3 and a solid precipitated. This solid was filtered and dried to afford the product 56. Yield = 8.10 g, 61%. 1H NMR (0334) (DMSO-d6) delta 7.87 (1H, d, J = 7.9 Hz), 6.36 (1H, d, J = 7.9 Hz), 3.90 (3H, s), 3.87 (3H, s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6231-18-1, 2,6-Dimethoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC.; UPTON, Anna, Marie; COOPER, Christopher, Blair; MARCEL, Koenraad, Jozel Lodewijk; GUILLEMONT, Jerome, Emile Goerges; VAN DEN BROECK, Walter Marcel, Mathilde; PALMER, Brian, Desmond; MA, Zhenkun; (186 pag.)WO2017/155909; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 88912-21-4, name is 6-Chloro-4-methoxypicolinic acid. A new synthetic method of this compound is introduced below., Application In Synthesis of 6-Chloro-4-methoxypicolinic acid

Synthesis Example 19 Synthesis of N-[(2,6-Difluorophenyl)sulfonyl]-6-chloro-4-methoxy-2-pyridinecarboxamide [Compound (I-975)] Using 2,6-difluorobenzenesulfonamide [Compound (III-14)] (0.309 g, 1.6 mmol) and 6-chloro-4-methoxypicolinic acid [Compound (II-75)] (0.3 g, 1.6 mmol), the Compound (I-975) was synthesised according to the process of Synthesis Example 3. White solid, yield: 0.3129 g, percent yield: 54.0%, m.p.: 160-163 C. IR KBr cm-1: 3262, 1725, 1620, 1434, 1398, 1317, 1188, 1029, 891, 642. 1H-NMR (60 MHz, CDCl3, 6): 3.8 (3H, s, OCH3), 6.7-7.5 (4H, m, aromatic ring H*3, pyridine ring H), 7.43 (1H, d, J=2 Hz, pyridine ring H), NH indistinctness.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 88912-21-4, 6-Chloro-4-methoxypicolinic acid.

Reference:
Patent; Kureha Kagaku Kogyo K.K.; US6610853; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem