Pyridine-derivatives

Related Products of 34392-85-3, Adding some certain compound to certain chemical reactions, such as: 34392-85-3, name is 3-Amino-2-chloro-6-methoxypyridine,molecular formula is C6H7ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34392-85-3.

Bring a solution of 2-chloro-6-methoxy-3-nitro-pyridine (2. 8 g, 0. 018 mol) in 75% H2SO4 (15 mL) to 0C using an ice bath. Slowly add a solution of NaN02 in water (5 mL) to the reaction mixture and stir for 30 minutes. Add three molar equivalents of CuCI in concentrated HCl and stir for 15 minutes. Heat the mixture at 80C for 30 minutes. Pour onto ice, extract the aqueous with ethyl acetate, dry the organic layer (NA2SO4) and concentrate under reduced pressure. Purify using flash column chromatography (hexanes to 10% ethyl acetate/hexanes eluent) to afford the title compound.

According to the analysis of related databases, 34392-85-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NEUROGEN CORPORATION; WO2005/7648; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 76469-41-5 ,Some common heterocyclic compound, 76469-41-5, molecular formula is C5H2F3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6.65 g of the compound obtained in Step 3 and 4.6 ml of hydrazine monohydrate were added to 100 ml of n-propanol. The resulting mixture was refluxed for 6 hours, and distilled under a reduced pressure to remove the solvent. The residue thus obtained was dissolved in 80 ml of chloromethane, washed with water, and dried over anhydrous magnesium sulfate. The resulting organic layer was concentrated under a reduced pressure to obtain 6.20 g (yield: 85.6%) of the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 76469-41-5, 2,3,5-Trifluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Park, Tae-Ho; Zhao, Long-Xuan; Lee, Sang-Ho; US2006/47124; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 72587-15-6, 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine, blongs to pyridine-derivatives compound. name: 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine

Compound WXOO2-1 (295.68 mg, 662.13 tmol) and compound WXOO1-2 (354.9 mg, 1.30 nmol) weredissolved in acetonitrile (3.00 mE) at room temperature,followed by the addition of potassium carbonate (183.03mg, 1.32 mmol). The reaction mixture was heated at roomtemperature and stirred for 2 hours. After the reaction, themixture was diluted with water (10 mE) and extracted withethyl acetate (5 mEx2). The organic phases were combinedand dried over anhydrous sodium sulfate, followed byfiltration. The filtrate was concentrated under reduced pressure to remove the solvent. The obtained residue wasisolated by column chromatography (eluent: petroleumether/ethyl acetate=1 0/1-2/1, volume ratio) to obtain thetarget product WXOO2-2. MS-ESI mlz: 464.0 [M+H].

The synthetic route of 72587-15-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.; LUO, Yunfu; YANG, Chundao; LEI, Maoyi; LIU, LING; HU, Guoping; LI, Jian; CHEN, Shuhui; US2019/177318; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of Picolinaldehyde

2-Pyridylbenzaldehyde (10.7 g, 0.1 mol), malonic acid (25.5 g, 0.25 mol) was added to a 100 ml round bottom flask.30 ml of pyridine was added as a solvent, magnetically stirred, and after all of it was dissolved, 1.6 g of piperidine was injected into the system.The oil bath was heated to 65 C and reacted for 3 h.The reaction was followed by thin layer chromatography, and after the reaction was completed, the reaction solution was cooled to 0-5 C.Pour into a mixture of ice and water containing concentrated hydrochloric acid (12 mol / l, 50 ml), a large amount of white solids precipitated, suction filtration,The desired 2-pyridine acrylic acid was obtained in a molar yield of 78%.

With the rapid development of chemical substances, we look forward to future research findings about 1121-60-4.

Reference:
Patent; Danyang Ning David Fang To Detect Co., Ltd.; Wei Qian; (4 pag.)CN109748851; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5346-38-3, Pyridine-2-carbothioamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5346-38-3, blongs to pyridine-derivatives compound. Computed Properties of C6H6N2S

Pyridinecarbothioamides 26-28 (1 eq.) and dichloroacetone(1 eq.) were dissolved in toluene (1 M) and heated to reflux (110 C).After completion of the reaction, the mixture was cooled to roomtemperature and extracted with EtOAc (3 times) and the organiclayer was washed (brine), dried (MgSO4), filtered and concentratedin vacuo. The product was purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5346-38-3, its application will become more common.

Reference:
Article; Louvel, Julien; Guo, Dong; Soethoudt, Marjolein; Mocking, Tamara A.M.; Lenselink, Eelke B.; Mulder-Krieger, Thea; Heitman, Laura H.; Ijzerman, Adriaan P.; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 681 – 691;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 36052-24-1 , The common heterocyclic compound, 36052-24-1, name is Methyl 6-aminonicotinate, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 15 (1.0 equiv., 3.94 mmol, 0.600 g) was added portion wise to a suspension OfLiAlH4 (3.00 equiv., 11.83 mmol, 0.449 g) in dry THF (17 ml) at 00C. The reaction mixture was stirred at room temperature overnight. Excess LiAlH4 was destroyed by addition of methanol (while cooling on ice), the reaction mixture was filtered over Celite and the filtrate concentrated under reduced pressure. The crude product was purified by column chromatography (dichloromethane / methanol 75:25) to give 6-amino-3-pyridinemethanol (16) (0.330 g, yield = 67%) as a white solid. 1H NMR (delta, CD3OD): 4.43 (2H, s), 6.58 (IH, d, J = 8.5 Hz), 7.48 (IH, dd, J = 8.5, ~ 2 Hz) 7.86 (IH, d, J ~ 2 Hz)

The synthetic route of 36052-24-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tibotec Pharmaceuticals Ltd.; WO2007/113290; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 38533-61-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38533-61-8, name is 2-Chloro-6-methoxy-3-nitropyridine, molecular formula is C6H5ClN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A suspension of 2-chloro-6-methoxy-3-nitropyridine (20.85 g, 110.57 mmol) in concentrated hydrochloric acid (37%) (171 mL, 5528.49 mmol) was stirred at 90 0C for 3 hours and allowed to cool to ambient temperature. The suspension was adjusted to pH 5 with 2M NaOH and the aqueous mixture was then continually extracted with EtOAc (250 mL). The organics were concentrated to afford a yellow solid which was filtered off and washed with Et2theta (200 mL). The solid was stirred in EtOAc (200 mL) and the green insoluble solid filtered off. Both filtrates were combined and dried (MgSO4) before concentrating to yield as 6-chloro-5-nitropyridin-2-ol a yellow solid (14.7 g, 84.22 mmol, 76 %).1R NMR (400 MHz, DMSOd6) delta 6.52 (IH, d), 8.26 (IH, d), no OH peak observed, m/z 173 (M-H)”

According to the analysis of related databases, 38533-61-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/24821; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 17997-47-6, Adding some certain compound to certain chemical reactions, such as: 17997-47-6, name is 2-(Tributylstannyl)pyridine,molecular formula is C17H31NSn, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17997-47-6.

A high-pressure vial was filled with the (S)-1-(4-bromobenzyl)-N-(1-(4-nitrophenyl)ethyl)- 1H-indole-5-carboxamide (37 mg, 0,08 mmol, 1 equiv), 2-(tributylstannyl)pyridine (28 muL, 0.09 mmol, 1.1 equiv), LiCl (10 mg, 0.24 mmol, 3 equiv), Pd(PPh3)4(9 mg, 0.008 mmol, 0.1 equiv), and anhydrous DMF (1 mL). The mixture was degassed for 5 min under argon atmosphere and the vial was sealed. The reaction mixture was heated at 120C for 1 h under microwaves. The solution was then concentrated in vacuo, filtered and purified by preparative HPLC to afford a beige powder (18 mg, 0.4 mmol, 50%). ESI-MS (m/z): 477 [M+H]+.

According to the analysis of related databases, 17997-47-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; UNIVERSITY OF TOLEDO; GRIFFIN, Patrick R.; KAMENECKA, Theodore Mark; LECKA-CZERNIK, Beata; WO2015/161108; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1136-52-3, name is (2,2,8-Trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C11H15NO3

2.09 g (3.5 mmol) of 5-hydroxymethyl2,2-dimethyl-4H-[1 ,3]dioxino[4,5-c]picoline was dissolved in 50 ml_ EtOAc then cooled to 0 C. 1 ml_ triethylamine was added followed by 1.15 g pf methane sulfonyl chloride. The mixture was stirred for 30 min. A solution of 1.12 g 4-fluorophenol in 5 ml_ DMF was cooled to 0 C and 1.12 g potassium tert-butanoate was added to form a phenol salt. This solution was added to the other at which point a gel formed. This was stirred and allowed to warm to room temperature for 1 h. The solution was then quenched by addition of water and adjusting the pH to 4 with acetic acid. The organic phase was evaporated. The residue was then adsorbed on silica gel then washed over a pad of silica gel with DCM. The DCM was evaporated to yield 2.4 g of a clear oil which spontaneously crystallized.

With the rapid development of chemical substances, we look forward to future research findings about 1136-52-3.

Reference:
Patent; MONTREAL HEART INSTITUTE; POIRIER, Steve; STRANIX, Brent Richard; MAYER, Gaetan; (82 pag.)WO2019/84681; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2457-47-8, name is 3,5-Dichloropyridine. This compound has unique chemical properties. The synthetic route is as follows. name: 3,5-Dichloropyridine

To a 3-neck 12 L round bottom flask add tetrahydrofuran (THF, 3 L) and diisopropylamine (DIPA, 315 mL, 2.24 mol) and cool to -78 C. Add slowly n-butyllithium (1.6 M in hexanes, 1400 mL, 2.24 mol). After the addition is complete and the temperature has settled at -78 C. slowly add a solution of 3,5-dichloropyridine (296.7 g, 2.00 mol) which immediately forms a yellow solution that changes to a rust colored suspension. After the addition is complete and the temperature has settled at -78 C. slowly add acetaldehyde (230 mL, 4.05 mol) in THF (600 mL). Continue stirring at -78 C. After 3 hours, remove the dry ice bath and begin quenching the reaction by the dropwise addition of saturated aqueous ammonium chloride (1 L). Allow the reaction to warm to room temperature (RT) overnight with stirring. Dilute the mixture with methyl-tert-butylether (MTBE, 2 L), saturated aqueous ammonium chloride (1 L) and water (2 L). Partition and wash organics with saturated aqueous sodium chloride (brine). Extract the aqueous phase with MTBE (1.5 L). Combine the organic layers, dry over sodium sulfate, filter and concentrate in vacuo. Purify the residue by silica gel chromatography [25% ethylacetate (EA) in hexanes] to give the title compound as a red oil. Yield: 352 g (90%). MS (ES) m/z 192 [M+1]+.

With the rapid development of chemical substances, we look forward to future research findings about 2457-47-8.

Reference:
Patent; ELI LILLY AND COMPANY; US2012/83511; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem