Pyridine-derivatives

Adding a certain compound to certain chemical reactions, such as: 53014-84-9, 2-Methyl-5-formylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-Methyl-5-formylpyridine, blongs to pyridine-derivatives compound. Application In Synthesis of 2-Methyl-5-formylpyridine

C. Preparation of 6-methylnicotinaldehyde oxime To a solution of 6-methylnicotinaldehyde (1.67 g, 13.79 mmol) in 27.6 mL MeOH, hydroxylamine (50% weight in water, 0.87 mL, 14.2 mmol) was added. The reaction mixture was stirred at room temperature for 2 h and then at 40 C. for an additional 2 h. The reaction mixture was concentrated to obtain 1.76 g (94%) of the title compound as a light brown solid. HPLC: retention time=0.20 min.

The synthetic route of 53014-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sun, Chongqing; Sher, Philip M.; Wu, Gang; Ewing, William R.; Huang, Yanting; Lee, Taekyu; Murugesan, Natesan; Sulsky, Richard B.; US2007/4772; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 104830-06-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 104830-06-0, name is 2-Amino-3-iodopyridine, molecular formula is C5H5IN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of the substituted 2-iodoaniline or 2-bromoaniline (1.0 equiv), DMAP (0.05 equiv) and NEt3 (2.0 equiv) was prepared in CH2Cl2 (2mL) and cooled to 0 C. The acyl chloride solution was added dropwise into the solution. After 5 minutes, the reaction was allowed to warm to room temperature and was stirred overnight. The reaction was quenched with a saturated NaHCO3 solution and extracted with CH2Cl2 twice. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated in vacuo. The resulting crude amide was used in next step without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 104830-06-0, 2-Amino-3-iodopyridine.

Reference:
Article; Xiao, Genhua; Chen, Liang; Deng, Guobo; Liu, Jianbing; Liang, Yun; Tetrahedron Letters; vol. 59; 19; (2018); p. 1836 – 1840;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 60290-21-3, Adding some certain compound to certain chemical reactions, such as: 60290-21-3, name is 4-Chloro-1H-pyrrolo[3,2-c]pyridine,molecular formula is C7H5ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60290-21-3.

General procedure: To a solution of 4-chloro-lH-pyrrolo-[3,2-c]-pyridine [60290-21-3] (2.0 g, 13.1 mmol) dissolved in DMF (30.5 mL, 0.944 g/mL, 393.2 mmol) at 0C was added portionwise sodium hydride (1.1 g, 28.8 mmol). The reaction mixture was allowed to reach rt and stirred 45 min, after which it was re-cooled to 0C and l-bromobutane (2.1 mL, 1.27 g/mL, 19.7 mmol) was added dropwise. The mixture was then allowed to reach rt and stirred overnight. NaHC03 sat solution was added and the aqueous phase was extracted with EtOAc. The combined organic extracts were washed with water and brine, then dried over MgS04 and concentrated in vacuo. The crude residue was purified by column chromatography (silica gel; gradient Heptane/EtOAc from 100/0 to 50 /50) to yield 1-1 (2.7 g, 98.7%) as a yellow liquid

According to the analysis of related databases, 60290-21-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; TRESADERN, Gary John; MARTINEZ LAMENCA, Carolina; LEENAERTS, Joseph Elisabeth; OEHLRICH, Daniel; BUIJNSTERS, Peter Jacobus Johannes Antonius; VELTER, Adriana, Ingrid; VAN ROOSBROECK, Yves, Emiel, Maria; (171 pag.)WO2019/243535; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 16179-97-8, 2-(Pyridin-2-yl)acetic acid hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-(Pyridin-2-yl)acetic acid hydrochloride, blongs to pyridine-derivatives compound. Quality Control of 2-(Pyridin-2-yl)acetic acid hydrochloride

To a suspension of 5-nitroindoline (3.28 g), 2- pyridylacetic acid hydrochloride (3.82 g), 1- [3- (dimethylamino) PROPYL]-3-ETHYLCARBODIIMIDE hydrochloride (4.22 g) and 1-hydroxybenzotriazole hydrate (3.37 g) in dichloromethane (100 ml) was added dropwise triethylamine (4.45 g) at ambient temperature and the resultant solution was stirred at ambient temperature for 18 hours. The mixture was poured into water and the separated organic layer was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel eluting with ethyl acetate to give 5-nitro-l- (2-pyridinylacetyl) indoline (3.58 g) as a yellow solid. 1H-NMR (DMSO-d6) : 8 3.26 (2H, t, J=8.5 Hz), 4.10 (2H, s), 4.33 (2H, t, J=8.5 Hz), 7.25-7. 35 (1H, m), 7.38 (1H, d, J=7.8 Hz), 7.75- 7.9 (1H, m), 8.1-8. 2 (3H, m), 8.50-8. 55 (1H, m) APCI-MS (m/z): 284 (M+H) +

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16179-97-8, 2-(Pyridin-2-yl)acetic acid hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; DAISO CO., LTD.; WO2004/39795; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 72990-37-5, 3-Chloroisonicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 72990-37-5, blongs to pyridine-derivatives compound. Formula: C6H4ClNO

EXAMPLE 38 Production of 3-((3-chloropyridin-4-yl)methyl)-5-(methoxycarbonyl)-2-methylindole (67) According to the method of Example 33, obtained is 3-((3-chloropyridin-4-yl)methyl)-5-(methoxycarbonyl)-2-methylindole (67) (0.355 g) from 5-(methoxycarbonyl)-2-methylindole (0.486 g), 3-chloropyridine-4-carboxyaldehyde (0.40 g), triethylsilane (0.896 g) and trifluoroacetic acid (0.439 g). 1H-NMR (CDCl3, delta ppm): 2.38 (3H, s), 3.89 (3H, s), 4.16 (2H, s), 6.82 (1H, d, J=5.0 Hz), 7.33 (1H, d, J=8.5 Hz), 7.87 (1H, d, J=8.7 Hz), 8.08 (1H, s), 8.20 (1H, brs), 8.25 (1H, d, J=5.0 Hz), 8.57 (1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,72990-37-5, its application will become more common.

Reference:
Patent; Cell Pathways, Inc.; US6410584; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 58530-50-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58530-50-0, name is 2-(Pyridin-2-yloxy)acetic acid, molecular formula is C7H7NO3, molecular weight is 153.14, as common compound, the synthetic route is as follows.

General procedure: To the mixture of compounds (IVa-c)(2 mmol) in dry acetonitrile (15 mL), triethylamine(3 mmol) followed by substituted piperazines(2 mmol) was added. The mixture was stirred for30 min and TBTU (2mmol) was then added and stirring was continued at room temperature under an inert atmosphere for 10-24 h; the completion of thereaction was monitored by TLC using chloroform-methanol (9 : 1) as eluent. The solvent was evaporatedat reduced pressure, quenched by the addition of coldwater (20 mL), and the obtained solids (Va), (Vb), (Vc),(Vd), (Ve), (Vf), (Vi), and (Vk) were filtered, dried, andrecrystallized from ethanol. In contrast, compounds(Vg), (Vh), (Vj), and (Vl) were obtained by extractingwith ethyl acetate. The extract was washed successivelywith a solution of 10% HCl (20 mL), 10% NaHCO3(20 mL), and water (20 mL). The organic layer wasdried over anhydrous sodium sulfate and evaporated,the crude product was purified by column chromatography (eluent: hexane-dichloromethane-acetone,5 : 3 : 2) to achieve pure piperazine derivatives. Thephysical and analytical data of the synthesized titlecompounds (Va-l) are given below.

The chemical industry reduces the impact on the environment during synthesis 58530-50-0, I believe this compound will play a more active role in future production and life.

Reference:
Article; Al-Ghorbani; Rekha; Lakshmi Ranganatha; Prashanth; Veerabasappagowda; Khanum; Russian Journal of Bioorganic Chemistry; vol. 41; 5; (2015); p. 554 – 561; Bioorg. Khim.; vol. 41; 5; (2015); p. 554 – 561,8;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 561297-96-9 ,Some common heterocyclic compound, 561297-96-9, molecular formula is C6H7FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of (R) -2- (5-amino-2- (furan-2-yl) -7H-pyrazolo [4, 3-e] [1, 2, 4] triazolo [1, 5-c] pyrimidin-7-yl) -2-phenylpropanoic acid (1.54 g, 3.96 mmol) , HATU (1.65 g, 4.34 mmol) and DIPEA (1.53 g, 15.15 mmol) in THF (30 ml) was added (5- fluoropyridin-2-yl) methanamine (0.50 g, 3.97 mmol) . The reaction mixture was stirred at r.t. for 15h. After completion, the reaction mixture was washed with H 2O (20 ml) and then extracted with DCM (25 ml X 2) . The organic layer was dried over Na 2SO 4, filtered and then concentrated under reduced pressure to afford a residue. The residue was purified by column chromatography with DCM: MeOH (30: 1) to afford the product (1.37 g, 70%) . 1H NMR (400 MHz, DMSO-d6) delta 8.41 (d, J = 4Hz, 1H) , 8.26 (s, 1H) , 8.23 (t, J = 4Hz, 1H) , 8.05 (s, 2H) , 7.95 (s, 1H) , 7.67 (td, J = 8Hz, 4Hz, 1H) , 7.53 (dd, J = 8Hz, 4Hz, 1H) , 7.34-7.20 (m, 6H) , 6.74 (s, 1H) , 4.41 (qd, J = 16Hz, 4Hz, 2H) , 2.38 (s, 3H) ppm. MS: M/e 498 (M+1) +.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 561297-96-9, 2-(Aminomethyl)-5-fluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BEIGENE, LTD.; ZHANG, Guoliang; ZHOU, Changyou; (152 pag.)WO2019/196803; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 846021-26-9, name is 2-Amino-6-methylnicotinic acid, molecular formula is C7H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C7H8N2O2

2-Amino-6-methyl nicotinic acid (3.04 g) was suspended in N,N-dimethylformamide (60 mE), and potassium carbonate (5.53 g) was added to the suspension, followed by stirring at 40 C. for 30 minutes. Solution (I) was dropwise added to the resulting suspension, followed by stirring with heating at 80 C. for 2 hours. The reaction solution was cooled to room temperature, and the N,N-dimethylformamide (50 mE, 71%) was removed by distillation under reduced pressure. Iced water (100 mE) was added to the residue, followed by stirring at room temperature for minutes. Precipitated crystals were collected by filtration and were dried to give 6.13 g (yield: 91%) of the target product (Compound 6 shown in Table 1). According to purity analysis by liquid chromatography, the purity of thus obtained target product was high, 98.5%. A melting point thereof was 120 C. to 121 C.10066] ?H-NMR (CDC13) oeppm: 2.40 (3H, s), 5.31 (2H, s), 6.10-6.91 (2H, br), 6.46 (1H, d), 6.89 (1H, d), 7.00 (1H, t), 7.16 (2H, d), 7.43 (2H, d), 7.67-7.72 (1H, t), 8.03 (1H, d), 8.20 (1H, d)

With the rapid development of chemical substances, we look forward to future research findings about 846021-26-9.

Reference:
Patent; AGRO-KANESHO CO., LTD.; AIZAWA, Ryo; OKADA, Itaru; (8 pag.)US2016/318868; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1000342-71-1, 6-Bromo-1H-pyrrolo[3,2-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1000342-71-1, blongs to pyridine-derivatives compound. Product Details of 1000342-71-1

To a stirred solution of 6-bromo-1H-pyrrolo[3,2-c]pyridine (2.0 g, 10.2 mmol) in DCM (40 mL), anhydrous AICI3 (2.713 g, 20.4 mmmol) was added at 0C. The resulting mixture was stirred for 15 minutes at RT and then butyryl chloride (2.162 g, 20.4 mmol) was added. The reaction mixture it was allowed to stir at RT for 16h. The mixture was diluted with MeOH and the solution was concentrated under reduced presure. The crude compound was basified to pH~8 using aq. saturated NaHC03 solution and extracted with EtOA. The combined organic phases were dried over anhydrous NaSOt, filtered and concentrated under reduced pressure. The crude compound was triturated with diethyl ether, filtered and dried under vacuum to afford the title compound (1.5 g, 55%) as an off-white solid. LC-MS (method 16): Rt = 1.92 min; m/z = 267.14 (M+H+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1000342-71-1, 6-Bromo-1H-pyrrolo[3,2-c]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; ORYZON GENOMICS, S.A.; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; (195 pag.)WO2018/149986; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1570-48-5, 1-(Pyridin-3-yl)propan-1-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H9NO, blongs to pyridine-derivatives compound. Computed Properties of C8H9NO

Precursor 3 n: 1-Pyridin-3-yl-propylamine 0.9 g of the title compound was obtained from 1 g of 3-propionylpyridine according to general method 3 B. Precursor 3 s: 1-Cyclopropyl-1-phenylmethylamine Hydrochloride

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1570-48-5, 1-(Pyridin-3-yl)propan-1-one, and friends who are interested can also refer to it.

Reference:
Patent; Brendel, Joachim; Pirard, Bernard; Peukert, Stefan; Kleemann, Heinz-Werner; Hemmerle, Horst; US2003/187033; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem