Pyridine-derivatives

Reference of 1594-58-7, Adding some certain compound to certain chemical reactions, such as: 1594-58-7, name is N-Hydroxynicotinimidamide,molecular formula is C6H7N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1594-58-7.

General procedure: The newly synthesized acyl chloride dissolved intoluene (10 mL) was slowly added to a solution ofamidoxime (2.5 mmol) dissolved in toluene (40 mL) in a250 mL round-bottomed flask at 25 oC and under constantstirring. After the addition, the solution was refluxed for20 h, and then washed with sodium carbonate solution. Theorganic phase was dried with anhydrous sodium sulfateand thereafter the toluene was removed under vacuumby heating. A solid was obtained, which was purified byfash column chromatography using a hexane/ethyl acetatemixture as eluent with an increasing polarity gradient (9:1to 6:4).20

According to the analysis of related databases, 1594-58-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cunha, Felipe S.; Nogueira, Joseli M. R.; De Aguiar, Alcino P.; Journal of the Brazilian Chemical Society; vol. 29; 11; (2018); p. 2405 – 2416;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1211534-25-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211534-25-6, name is 4-Bromo-5-chloro-2-methoxypyridine, molecular formula is C6H5BrClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[00257j 27F. 4-((3 ,4-cis)-4-((tert-Butyldimethylsilyl)oxy)-3 -methylpiperidin- l-yl)-5 – chloro-2-methoxypyridine: A mixture of 27B (9.70 g, 43.6 mmol), 27E (10.0 g, 43.6mmol), and K2C03 (12.0 g, 87.0 mmol) in DMSO (14.5 mL) was vigorously stirred at110 C overnight. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water and brine, dried (MgSO4), and concentrated. Purification via silica chromatography gave 27F as an oil (14.3 g, 77% yield). LC-MS Anal. Calc?d for C18H31C1N2O2Si: 370.18, found [M+H] 371.2.

According to the analysis of related databases, 1211534-25-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ELLSWORTH, Bruce, A.; JURICA, Elizabeth, A.; SHI, Jun; EWING, William, R.; YE, Xiang-Yang; WU, Ximao; ZHU, Yeheng; SUN, Chongqing; WO2014/78609; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 13534-98-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13534-98-0, name is 4-Amino-3-bromopyridine. This compound has unique chemical properties. The synthetic route is as follows.

Ethyl (3-bromopyridin-4-yl)carbamate (S7).3-Bromopyridin-4-amine (100 mol%) was dissolved in CH2Cl2 (0.2 M), and cooled to 0 C. Ethyl chloroformate (110 mol%) was added at 0 C, then diisopropylethylamine (150 mol%) was added. The mixture was stirred at 0 C for 30 min, warmed to ambient temperature, and stirredor additional 2-3 h. After completion, the mixture was diluted with CH2Cl2, and washed withwater and brine. The combined aqueous layer was washed with CH2Cl2. The combined organiclayer was dried over anhydrous Na2SO4, and concentrated in vacuo. The title compound S7 was obtained as an off white solid in 86% yield (610.6 mg, 2.49 mmol) after flash column chromatography (hexanes/EtOAc = 1:1). 1H NMR (asterisk denotes minor rotamer peaks, 400 MHz, CDCl3) delta 8.82* (d, J = 0.5 Hz, 1H), 8.59* (d, J = 5.6 Hz, 1H), 8.59 (d, J = 0.4 Hz, 1H), 8.40 (dd, J = 5.6, 0.6 Hz, 1H), 8.15 (d, J =5.6 Hz, 1H), 7.30 (br s, 1H), 7.22* (dd, J = 5.1, 0.5 Hz, 1H), 4.28 (q, J = 7.1 Hz, 2H), 4.24* (q, J= 7.1 Hz, 2H), 1.35 (t, J = 7.1 Hz, 3H), 1.23* (t, J = 7.1 Hz, 3H). 13C NMR (asterisk denotes minor rotamer peaks, 100 MHz, CDCl3) delta 153.0*, 152.4*, 151.6,149.5, 142.8, 124.7*, 113.2, 109.7, 63.8*, 62.2, 14.4, 14.0*. IR (neat) 3405, 2980, 1739, 1582, 1506, 1236, 1205 cm-1.HRMS (ESI+) calcd. for C8H10BrN2O2 [M+H]+ 244.9920, found 244.9920.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13534-98-0, 4-Amino-3-bromopyridine.

Reference:
Article; Shin, Inji; Ramgren, Stephen D.; Krische, Michael J.; Tetrahedron; vol. 71; 35; (2015); p. 5776 – 5780;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 113975-22-7, 2-Fluoro-3-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H3FIN, blongs to pyridine-derivatives compound. HPLC of Formula: C5H3FIN

General procedure: 1-(Indol-3-yl)-N-Boc-THIQ 4a (100 mg, 0.287 mmol, 1.0 equiv.), iron(III)-chloride (4.7 mg, 28.7 mumol, 0.1 equiv.), and K3PO4 (122 mg, 0.574 mmol, 2.0 equiv.) were placed in a 2 mL glass vial, and aryliodide (0.431 mmol, 1.5 equiv.) and DMEDA (5.6 muL, 57.4 mumol, 0.20 equiv.) were added followed by dry toluene (300 muL). The reaction mixture was purged with argon for 30 seconds, the vial sealed and heated to 135 C and stirred at this temperature for 24 hours. The black slurry was cooled down to rt, diluted with DCM and filtered through a plug of celite. The solvent of the filtrate was evaporated and the crude product directly subjected to column chromatography using gradient elution with PE_EtOAc=100:0 0:40 (50 minutes) to afford the desired products 7a-e,g.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,113975-22-7, 2-Fluoro-3-iodopyridine, and friends who are interested can also refer to it.

Reference:
Article; Ghobrial, Michael; Mihovilovic, Marko D.; Schnuerch, Michael; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 2186 – 2199;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 18614-51-2, 4-Amino-2-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 18614-51-2, blongs to pyridine-derivatives compound. Recommanded Product: 18614-51-2

Method A) CuCl2 (0.0680 g, 0.513 mmol) was dissolved in 3 mL of water to yield a blue,opaque solution. 2-F-4-AP (0.111 g, 0.991 mmol) in 5 mL of water was added to the CuCl2solution. The aquamarine, opaque solution was left to evaporate at room temperature forthree weeks. Dark green prisms were recovered by vacuum filtration, washed with cold waterand allowed to air dry to give 0.0612 g (13.7%). Single crystals (dark green needles) weregrown through recrystallization of the prisms from water over the course of a month. IR (KBr)nu – 3413 m, 3327 m, 3220 m, 3071w, 1639s, 1560 m, 1510 m, 1475 m, 1375s, 1267s, 1195 m,1026 m, 994 m, 834 m, 777 m, and 656w cm-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18614-51-2, its application will become more common.

Reference:
Article; Krasinski, Claire A.; Solomon, Benjamin L.; Awwadi, Firas F.; Landee, Christopher P.; Turnbull, Mark M.; Wikaira, Jan L.; Journal of Coordination Chemistry; vol. 70; 5; (2017); p. 914 – 935;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 63071-03-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 63071-03-4 as follows.

BuLi (2.5 M, 49.0 ml, 122 mmol) was added to a solution of 2-methoxy-6-methylpyridine in THF (300 ml) at -78 C. over a period of 30 min. After warming the mixture to 0 C. over a period of 1 h, the reaction was re-cooled to -78 C. and acetaldehyde (22.3 ml, 407 mmol) was slowly added. The mixture was stirred for 1 h at -78 C. and allowed to warm to ambient temperature. Addition of sat. aq. NH4Cl and extraction with EtOAc was followed by a wash of the organic layer with sat. aq. NaHCO3 and brine. Concentration of the organic layer in vacuo and chromatographic purification of the resulting residue gave 8.96 g (66%) of 1-(6-methoxypyridin-2-yl)propan-2-ol. 1H-NMR (CDCl3) delta 7.51 (dd, 1H), 6.71 (d, 1H), 6.63 (d, 1H), 5.18 (br s, 1H), 4.21 (qdd, 1H), 3.91 (s, 3H), 2.84 (dd, 1H), 2.77 (dd, 1H), 1.28 (d, 3H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63071-03-4, its application will become more common.

Reference:
Patent; Forest Laboratories Holdings Limited; US2007/281918; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 845827-14-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 845827-14-7, name is 2-Bromo-5-(difluoromethoxy)pyridine. A new synthetic method of this compound is introduced below.

Production Example 23 4-[5-(Difluoromethoxy)-2-pyridyl]benzenecarboxylic acid Operations similar to those of Production Example 14 were conducted using 4-carboxyphenylboronic acid and 2-bromo-5-(difluoromethoxy)pyridine, to provide the title compound as white solid. ESI-MS Found:m/z 266[M+H]+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,845827-14-7, 2-Bromo-5-(difluoromethoxy)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1657242; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19798-81-3, name is 6-Bromopyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

To a solution of 6-bromopyridin-2-amine (1 g, 5.78 mmol) in acetonitrile (10 mL) was added N-chlorosuccinimide (0.849 g, 6.36 mmol) and the mixture was heated at 80C for 12 hours. The mixture was filtered through diatomaceous earth and concentrated and the residue was dissolved in ethyl acetate and washed with water and brine. Drying over anhydrous sodium sulfate, filtration, concentration and purification by column chromatography (silica gel, 30% ethyl acetate in hexane) afforded the title compound. LCMS: 209.1 (M+2)+.

With the rapid development of chemical substances, we look forward to future research findings about 19798-81-3.

Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; TONG, Yunsong; BRUNCKO, Milan; CLARK, Richard F.; CURTIN, Michael L.; FLORJANCIC, Alan S.; FREY, Robin R.; GONG, Jianchun; HANSEN, Todd M.; JI, Zhiqin; LAI, Chunqiu; MASTRACCHIO, Anthony; MICHAELIDES, Michael; MIYASHIRO, Juliem; RISI, Roberto M.; SONG, Xiaohong; TAO, Zhi-fu; WOODS, Keith W.; ZHU, Guidong; PENNING, Thomas; SOUERS, Andrew; GOSWAMI, Rajeev; IQUTURI, Omprakash Reddy; DABBEERU, Madhu Babu; WO2014/139328; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 884495-36-7, Adding some certain compound to certain chemical reactions, such as: 884495-36-7, name is 6-Chloro-2-methylnicotinaldehyde,molecular formula is C7H6ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 884495-36-7.

A mixture of 6-chloro-2-methylpyridine-3-carboxaldehyde (3.00 g, 19.3 mmol), A- mercaptophenol (90% pure, 2.7Og, 19.3 mmol) and K2CO3 (1.66 g, 12.0 mmol) in DMF (20 mL) was stirred at room temperature for 16 h. Bromoacetic acid tert-butyl ester (6.00 g, 30.8 mmol) and K2CO3 (3.40 g, 24.6 mmol) were added, and the mixture was stirred for another 4 h. Aqueous work-up and purification by flash chromatography on silica gel (EtOAc/hexanes, 1 :4 in v/v) afforded 4-(5-fo?nyl~6-methyl-rhoyridin-2-ylsulfanyl)-benzoic acid tert-butyl ester as EPO a pale yellow solid (7.40 g, 100%). 1H NMR (CDCl3) delta 1.50 (s, 9H), 2.81 (s, 3H)5 4.57 (s, 2H), 6.66 (d, IH, J= 8.1 Hz), 6.97-7.01 (m, 2H), 7.51-7.55 (m, 2H), 7.79 (d, IH, J= 8.1 Hz), 10.19 (s, IH).

According to the analysis of related databases, 884495-36-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ANORMED INC.; WO2007/22371; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 779345-37-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 779345-37-8, name is 5-Fluoro-2-nitropyridine. A new synthetic method of this compound is introduced below.

To a solution of compound 73 (564 mg, 4.2 mmol, 1.2 eq) in dimethylacetamide (5 mL) at 0 C under nitrogen was added potassium tert-butoxide (513 mg, 4.6 mmol, 1.3 eq) portion wise. The mixture was stirred at 0 C for 1 h, and then a solution of compound 61 (500 mg, 3.5 mmol, 1.0 eq) in DMA (2 mL) was added portion wise. After addition, the reaction mixture was stirred at RT overnight. The reaction was quenched by water (15 mL) and extracted with EA (3 X 5 mL), dried over Na2S04, filtered and concentrated to give a crude residue (700 mg crude), which was used into next step without further purification. *H NMR (300 MHz, CDCb): delta 8.34-8.31 (m, 2 H), 7.72 (dd, J = 3.0 Hz, 9.0 Hz, 1 H), 4.07 (d, J = 6.0 Hz 2 H), 2.80- 2.76 (m, 2 H), 2.15 (s, 3 H), 1.89-1.81 (m, 2 H), 1.75-1.71 (m, 2 H), 1.37-1.23 (m, 3 H). LCMS: (M+H)+ = 252.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,779345-37-8, its application will become more common.

Reference:
Patent; BEIJING XUANYI PHARMASCIENCES CO., LTD.; SONG, Yuntao; CHEN, Xiaoqi; (188 pag.)WO2019/35008; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem