Pyridine-derivatives

Adding a certain compound to certain chemical reactions, such as: 128071-98-7, 4-Bromo-2-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H3BrFN, blongs to pyridine-derivatives compound. HPLC of Formula: C5H3BrFN

4-bromo-2-fluoropyridine (1.55 g, 8.81 mmol), tert-butyl piperazine-1-carboxylate (2.46 g, 13.22 mmol) and potassium carbonate (3.65 g, 26.41 mmol) in dimethylsulphoxide (10 mL) was heated in a sealed tube at 100 ºC with stirring. After stirring overnight the mixture was cooled and ethyl acetate and water were added. The organic layer was washed with brine, dried (MgSO4) and evaporated. Purification of the residue by flash chromatography (100% hexanes to 1:4 hexanes /ethyl acetate) gave the title compound (2.33 g, 78%) as a white solid. LRMS (m/z): 342/344 (M+1)+. 1H NMR (300 MHz, , CDCl3) delta ppm 1.49 (s, 9 H), 2.49 (bs, 2 H), 3.63 (t, J=5.77 Hz, 2 H), 4.08 (d, J=2.75 Hz, 2 H), 6.05 (br s, 1 H), 7.21 (t, J=7.69 Hz, 1 H), 7.27 – 7.31 (m, 1 H), 7.36 – 7.40 (m, 1 H), 7.51 (t, J=1.79 Hz, 1 H)

The synthetic route of 128071-98-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Almirall, S.A.; Vidal Juan, Bernat; Fernandez Collado, Juan Carlos; Erra Sola, Montserrat; Aguilar Izquierdo, Nuria; Mir Cepeda, Marta; Carranco Moruno, Ines; EP2489663; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 24484-93-3, Adding some certain compound to certain chemical reactions, such as: 24484-93-3, name is Methyl 4-chloropicolinate,molecular formula is C7H6ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24484-93-3.

13 g (62.5 MMOL) 1 are dissolved together with 2.98 g (31.24 MMOL) dry magnesiumchloride in THF. After 5 min 110 ML METHYLAMIN-SOLUTION (2M in THF) are added dropwise within 10 min and the suspension stirred for 2 h at room temperature. 120 ml water und 63 mL 1 M HCI-SOLUTION are added and the mixture is extracted three times with ethyl acetate. The combined organic phases are washed with brine, dried with NA2SO4, filtered and evaporated. Yield : 10.5 g (98. 5 %) 2, colourless oil.

According to the analysis of related databases, 24484-93-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GMBH; WO2005/4864; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 524955-09-7, Adding some certain compound to certain chemical reactions, such as: 524955-09-7, name is 3-Chloro-4-(pyridin-2-ylmethoxy)aniline,molecular formula is C12H11ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 524955-09-7.

General procedure: A mixture of (E)-N’-(2-cyano-4-nitrophenyl)-N,N-dimethylformimidamide (5) (2.99g, 13.7 mmol) and appropriate aniline (15.1 mmol) in glacial acetic acid (15.0mL) was refluxed for 2 h. The acetic acid was evaporated and the solid waswashed with water and diethyl ether and dried to afford the titled compounds.

According to the analysis of related databases, 524955-09-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Elkamhawy, Ahmed; Farag, Ahmed Karam; Viswanath, Ambily Nath Indu; Bedair, Tarek M.; Leem, Dong Gyu; Lee, Kyung-Tae; Pae, Ae Nim; Roh, Eun Joo; Bioorganic and Medicinal Chemistry Letters; vol. 25; 22; (2015); p. 5147 – 5154;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 115473-15-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115473-15-9, name is 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

2. Take the reaction tube, rotor, air head in the oven full drying, dryer cooling.CH3CN (1 mL) was stirred with molecular sieve at room temperature for 10 min under argon.Protected in argonFollowed by the addition of material C:(0.14 mmol, 27.5 mmol), Na2CO3 (0.29 mmol, 31.0 mg)Finally, alpha-cyclopropylcarbonyl-2-fluorobenzyl chloride (0.117 mmol, 25.0 mg, 20 muL) was slowly added and heated at 60 C for 12 h (reflux condenser). The solvent was spin dried and the column was directly chromatographed,The product was obtained as a white solid D (20.2 mg, yield 52%.)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 115473-15-9, 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride.

Reference:
Patent; Lanzhou University; Zhang Fumin; Peng Rui; Tang Shizhong; (9 pag.)CN107056803; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 59782-85-3, Adding some certain compound to certain chemical reactions, such as: 59782-85-3, name is 2,5-Dichloronicotinic acid,molecular formula is C6H3Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59782-85-3.

Lithium 2-amino-5-chloronicotinateA solution of 2,5-dichloronicotinic acid (20.2 g, 0.105 mol) in methanol (500 ml_) was cooled to 00C and neat thionyl chloride (38 mL, 63 g, 0.525 mol) was added over -30 min. The reaction mixture was stirred at 00C for 1 hour. The cooling bath was removed, the reaction temperature was allowed to warm to room temperature, and the reaction was allowed to stir for an additional 2 days at room temperature. The solvent was removed under reduced pressure to give an off-white residue. The residue was dissolved in Et2O (-500 mL) and the resulting solution was washed successively with satd. aq. NaHCO3 solution (-300 mL), water (-300 mL), and brine (-300 mL). The organic layer was separated, dried over anhydrous MgSO4, and filtered. Removal of the solvent under reduced pressure yielded methyl 2,5-dichloronicotinate (21.0 g, 97%) as a white solid.

According to the analysis of related databases, 59782-85-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2006/91428; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 82671-06-5, 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H2Cl2FNO2, blongs to pyridine-derivatives compound. Formula: C6H2Cl2FNO2

CDI (35.6 g, 220 mmol) was added portionwise to a solution of C1 (42 g, 200 mmol) in THF (400 mL).The mixture was stirred for 5 min, protected with Ar, heated to 50 C, and reacted for 1 h.After LC-MS monitoring, the starting material disappeared, and the reaction mixture was diluted with toluene (100 mL) and concentrated to half of the original volume.The resulting mixture was cooled to 0 C and ammonium hydroxide (55 mL, 400 mmol) was slowly added.The reaction was carried out for 10 min at room temperature, diluted with EA (200 mL) and washed with water (100 mL*3).The organic layer was dried over anhydrous Na 2 SO 4 and dried. PE/EA (10/1, 200 mL) beaten, filtered,The remaining mother liquor was concentrated to half of the initial volume, cooled to 0 C, and the solid was again precipitated and filtered.The two crops were combined to give a pale-yellow solid product 74-1 (22.10 g, yield 53%).The primary product was used in the next reaction without purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,82671-06-5, 2,6-Dichloro-5-fluoropyridine-3-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Weijing Biological Pharmaceutical (Shanghai) Co., Ltd.; Fan Houxing; Xie Yuli; (72 pag.)CN110256421; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 53014-84-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 53014-84-9, name is 2-Methyl-5-formylpyridine. A new synthetic method of this compound is introduced below.

Ethyl cyanoacetate (607 mg, 5,36 mmol), 6-methylpyridine-3~carbaldehyde (650 mg, 5.36 mmol), piperidine (0.26 mL) and acetic acid (48 mg) were siiiTed in eihanol (10 mL) at RT for 16 h. The mixture was diluted in TBME/Heptane and cooled on dry ice to induce precipitation. Solid formed was filtered off and washed with peniane to give the title compound as a white solid (0.89 g, 70%), 1H NMR (500 MHz, Chlorofonn-d) delta 8.78 (d, J – 2.3 Hz, 1H) 8.51 (dd, J – 8.3, 2.4 Hz, 1H), 8.23 (s, 1H), 7.32 (d, J = 8.3 Hz, 1 H), 4.40 (q, J = 7.1 Hz, 2H), 2.65 (s, 3H), 1.40(t, J – 7, 1 Hz, 3H). LCMS Method C: rt 1.08 min; 91 % m/z 216.9 (MH?),

At the same time, in my other blogs, there are other synthetic methods of this type of compound,53014-84-9, 2-Methyl-5-formylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; EVOTEC INTERNATIONAL GMBH; GAMPE, Christian, M.; KAHNE, Daniel, Evan; KAHNE, Suzanne, Walker; QIAO, Yuan; EAST, Stephen; PARKES, Alastair, L.; SOUTHEY, Michelle; HUNTER, James; WHITTAKER, Mark; ARTHUIS, Martin; (359 pag.)WO2016/191658; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1200498-46-9 ,Some common heterocyclic compound, 1200498-46-9, molecular formula is C7H3FN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Dimethylformamide (10 muL, 0.14 mmol) and oxalyl chloride (119 muL, 1.38 mmol) is added to acetonitrile (3.7 mL) and stirred at room temperature for 10 minutes. 5-Cyano-3-fluoro-pyridine-2-carboxylic acid (213 mg, 1.28 mmol) is added and the mixture is stirred for another 10 minutes.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1200498-46-9, 5-Cyano-3-fluoropicolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GREEN, Steven James; HEMBRE, Erik James; MERGOTT, Dustin James; SHI, Yuan; WATSON, Brian Morgan; WINNEROSKI, JR., Leonard Larry; US2014/371212; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1196155-38-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1196155-38-0, name is 2-Chloro-6-(trifluoromethyl)isonicotinonitrile, molecular formula is C7H2ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of methyl 3,5-dihydroxybenzoate 2 (163 mg, 0.97 mmol) in DMF (10 mL) at RT, were added K2C03 (161 mg, 1.16 mmol) and 2-chloro-6- (trifluoromethyl)isonicotinonitrile 1 (200 mg, 0.97 mmol). The reaction mixture was stirred at RT for 16 h. The mixture was quenched with water (20 mL) and extracted with EtOAc (2 x 20 mL), and the combined organic extracts were washed with brine (10 mL), dried (Na2S04), filtered and concentrated. The residue was purified (silica gel; eluting 20-25percent EtOAc/hexanes) to afford compound 3 (110 mg, 34percent) as a white solid. 1H NMR (500MHz, CDC13): delta 7.59 (s, 1H), 7.41 – 7.44 (m, 2H), 7.36 (s, 1H), 6.90 (br s, 1H), 3.91 (s, 3H); LCMS Mass: 339.1 (M++l).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1196155-38-0, 2-Chloro-6-(trifluoromethyl)isonicotinonitrile.

Reference:
Patent; PHARMAKEA, INC.; ROWBOTTOM, Martin W.; HUTCHINSON, John Howard; CALDERON, Imelda; (202 pag.)WO2016/144703; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1480-65-5, Adding some certain compound to certain chemical reactions, such as: 1480-65-5, name is 5-Chloro-2-fluoropyridine,molecular formula is C5H3ClFN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1480-65-5.

To a suspension of cesium carbonate (3.76 g, 11.5 mmol) in DMF (20 mL) at room temperature was added 5-chloro-2-fluoropyridine (1.00 mL, 9.96 mmol) and benzylmercaptan (1.15 mL, 9.80 mmol). The reaction mixture was stirred at room temperature for 16 h and heated to 60 °C for 6 h. The reaction mixture was diluted with Et20. The organic phase was washed with water (2 x), brine and dried over MgS04. The filtrate was concentrated under reduced pressure and the residue was purified by flash column chromatography on silica gel ( 5percent to 10percent EtOAc in heptane) to give the title compound (2.33 g, 9.88 mmol, 101percento yield) as a colorless oil that was used without further purification in the next step. MS) m/z = 236.1 [M+H]+

According to the analysis of related databases, 1480-65-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; MINATTI, Ana Elena; LOW, Jonathan, D.; ALLEN, Jennifer, R.; AMEGADZIE, Albert; BROWN, James; FROHN, Michael, J.; GUZMAN-PEREZ, Angel; HARRINGTON, Paul, E.; LOPEZ, Patricia; MA, Vu Van; NISHIMURA, Nobuko; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert, M.; SHAM, Kelvin; SMITH, Adrian, L.; WHITE, Ryan; XUE, Qiufen; WO2014/138484; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem