Pyridine-derivatives

Adding a certain compound to certain chemical reactions, such as: 67754-03-4, Methyl 2,5-dichloronicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 67754-03-4, blongs to pyridine-derivatives compound. HPLC of Formula: C7H5Cl2NO2

Description 64: 1-(5-chloro-3-(methoxycarbonyl)pyridin-2-yl)azetidine-3- carboxylic acid (D64)To a mixture 3-Azetidinecarboxylic acid (41 1 mg, 4.06 mmol) and triethylamine (1 .17ml, 8.47 mmol) in methanol (3ml), methyl 2-chloropyridine-3-carboxylate (700 mg, 3.38 mmol) was added and the mixture was heated at 150C under microwave irradiation 10 min (2 cycles of 5 min each ). Solvents were evaporated in vacuo and the residue was taken in water (5ml) and 1 M HCI (5ml) and extracted with ethylacetate (3x5ml). Collected organics after solvent evaporation afforded the title compound (D64) (880 mg)MS: (ES/+) m/z: 270.8 [MH+] C1 1 H1 1 CIN204 requires 270.04 1 H NMR (400 MHz, CHLOROFORM-d) delta ppm 8.23 – 8.32 (m, 1 H) 7.90 – 8.06 (m, 1 H) 4.31 – 4.45 (m, 2 H) 4.17 – 4.30 (m, 2 H) 3.84 – 3.95 (m, 3 H) 3.58 (tt, J=8.93, 6.1 1 Hz, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,67754-03-4, its application will become more common.

Reference:
Patent; ROTTAPHARM S.P.A.; BORRIELLO, Manuela; ROVATI, Lucio; STASI, Luigi Piero; BUZZI, Benedetta; COLACE, Fabrizio; WO2012/76063; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1202070-39-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1202070-39-0, name is (R)-1-(5-Fluoropyridin-2-yl)ethanamine hydrochloride, molecular formula is C7H10ClFN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step D: N-rrii?Vl-r5-Fluoropyridin-2-vnethyll-3-(5-methylpyridin-2-vn-5-[(R/SV2.2,2- trifluoro- 1 -hvdroxyethvPbenzamide; To a solution of 3-(5-methylpyridin-2-yl)-5-(2,2,2-trifluoro-l- hydroxyethyl)benzoic acid (25 mg, 0.072 mmol) in N^-dimethylformamide (0.7 mL) were added (li?)-l-(5-fluoropyridin-2-yl)ethanamine hydrochloride salt (23 mg, 0.11 mmol), EDC (20.7 mg, 0.11 mmol), HOAT (0.5 M in DMF; 72 muL, 0.036 mmol) and triethylamine (60 muL, 0.43 mmol). The reaction mixture was heated to 60 C. After 3 h, the mixture was cooled to ambient temperature and the solid in the reaction was filtered off. Purification by reverse phase chromatography (C-18, 75% water/ acetonitrile ? 48% water/ acetonitrile with 0.1% trifluoroacetic acid) gave the trifiuoroacetate salt of the title compound. HRMS 434.1484(M+l). 1H NMR (500 MHz, DMSOd6): delta 9.09 (d, J= 7.6 Hz, 1 H); 8.57 (d, J= 8.0 Hz, 2 H); 8.52 (d, J= 3.0 Hz, 1 H); 8.38 (s, 1 H); 8.05 (s, 1 H); 7.98 (d, J= 8.1 Hz, 1 H); 7.78 (dd, J= 8.2, 2.2 Hz, 1 H); 7.70 (td, J= 8.8, 3.0 Hz, 1 H); 7.52 (dd, J= 8.8, 4.5 Hz, 1 H); 7.01 (d, J= 5.6 Hz, 1 H); 5.37-5.31 (m, 1 H); 5.29-5.23 (m, 1 H); 2.37 (s, 3 H); 1.55 (d, J= 7.1 Hz, 3 H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1202070-39-0, (R)-1-(5-Fluoropyridin-2-yl)ethanamine hydrochloride.

Reference:
Patent; MERCK & CO., INC.; WO2009/58298; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 71701-92-3, Adding some certain compound to certain chemical reactions, such as: 71701-92-3, name is 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine,molecular formula is C6H2BrClF3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 71701-92-3.

To a solution of 3-bromo-2-chloro-5-(trifluoromethyl)pyridine (20.00 g, 0.077 mol) in toluene (400 ml), DMF (dimethylformaldehyde) (7.72 ml, 0.10 mol) was dropwise added at – 65C, followed by the addition of n-BuLi (1.57M solution in hexane; 64 ml, 0.10 mol). After stirring for 30 min, the reaction was terminated with 1 N HCI, and then, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered, and concentrated in a vacuum to obtain 2-chloro-5- (trifluoromethyl)pyridine-3-carbaldehyde. This produce was used in the subsequent reaction without further purification.

According to the analysis of related databases, 71701-92-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DONG-A ST CO.,LTD; PARK, Jang Hyun; SONG, Seung Hyun; CHUNG, Han Kook; KIM, Heung Jae; LEE, Ji Hye; JANG, Byeong Jun; KIM, Eun Jung; JUNG, Hae Hum; RYU, Chae Lim; HWANG, Jae-Sung; LEE, Hyung Ki; KANG, Kyung Koo; KIM, Soon Hoe; WO2014/157994; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89466-18-2, name is 6-Bromo-2-methoxypyridin-3-amine, the common compound, a new synthetic route is introduced below. SDS of cas: 89466-18-2

6-bromo-2-methoxy-3-amine (1.02g, WO2011068211 pamphlet) In acetonitrile (20mL) solution,At 0 , 37% aqueous solution of formaldehyde (1.22g)And the mixture was stirred for 10 minutes. The reaction mixture was cooled to room temperature, sodium triacetoxyborohydride (3.18g) was added,The reaction was stirred overnight at the same temperature.Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate,After filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexaEmissions: ethyl acetate = 9: 1 ? 4: 1) was purified by,6-bromo-2-methoxy -N, N-dimethyl-3-amine and 6-bromo-2-methoxy -N- methyl-pyridin-3-amine 2 was obtained 1 mixture (475 mg).

The synthetic route of 89466-18-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAISHO PHARMACEUTICAL COMPANY LIMITED; NISSAN CHEMICAL INDUSTRIES LIMITED; KURODA, SHOICHI; USHIKI, YASUNOBU; KAWAGUCHI, TAKANORI; FUSEGI, KEIKO; BOHNO, MASAHIRO; IMAI, YUDAI; UNEUCHI, FUMITO; IWAKIRI, KANAKO; TANAKA, HIROAKI; BOHNO, AYAKO; CHONAN, TOMOMICHI; ITOH, SHIN; OTA, HIROFUMI; ISHIYAMA, SEISHI; OKADA, TAKUYA; SASAKO, SHIGETADA; MONMA, SOUICHI; NIWA, MARIE; OKADA, TAKUMI; (289 pag.)JP2015/231988; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1196154-43-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1196154-43-4 as follows.

1,4-Dioxaspiro[4.5]decan-8-ol (0.25 g, 1.58 mmol) and 2-[2-chloro-6-(trifluoromethyl)pyridin-4-yl]propan-2-ol (0.2 g, 0.835 mmol) were dissolved in tetrahydrofuran (2 mL) and cooled to 0 C. and a 60% mixture of sodium hydride (70.0 mg, 1.75 mmol) in mineral oil was added and the reaction was stirred for 30 minutes at 0 C. and at 25 C. for 60 hours at which time TLC analysis indicated the presence of some product. The reaction was quenched with water, and was extracted with ethyl acetate and the organic extracts were washed with water, saturated NaCl, dried (MgSO4), and evaporated in vacuo. The residue was purified by LC (pH 2) to give the product. MS(ES):362 (M+1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1196154-43-4, its application will become more common.

Reference:
Patent; Incyte Corporation; Vaddi, Krishna; US2015/246046; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100-70-9, name is Picolinonitrile, molecular formula is C6H4N2, molecular weight is 104.11, as common compound, the synthetic route is as follows.Recommanded Product: 100-70-9

Compound 18 was synthesized according to the procedures reported in the literature (J. Org. Chem. 1998, 63, 1740-1741) as shown in Scheme 38.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100-70-9, Picolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; PURDUE PHARMA L.P.; NI, Chiyou; SHAO, Bin; TAFESSE, Laykea; YAO, Jiangchao; YU, Jianming; ZHOU, Xiaoming; WO2012/35421; (2012); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1211589-43-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211589-43-3, name is 3-Bromo-6-fluoropicolinic acid, molecular formula is C6H3BrFNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Para-toluenesulfonyl chloride (27.6 g) was added to a solution of Example 1.4.3 (14.5 g),pyridine (26.7 mL) and tert-butanol (80 mL) in dichloromethane (100 mL) at 0 C. The reaction wasstirred for 15 minutes, warmed to room temperature, and stirred overnight. The solution was concentrated and partitioned between ethyl acetate and Na2C03 solution. The layers were separated,and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, rinsedwith Na2C03 solution and brine, dried over sodium sulfate, filtered, and concentrated to provide thetitle compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211589-43-3, 3-Bromo-6-fluoropicolinic acid.

Reference:
Patent; ABBVIE INC.; BOGHAERT, Erwin, R.; JUDD, Andrew, S.; PHILLIPS, Andrew, C.; SOUERS, Andrew, J.; BRUNCKO, Milan; (503 pag.)WO2017/214301; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 113975-22-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 113975-22-7, name is 2-Fluoro-3-iodopyridine, molecular formula is C5H3FIN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 5 – 2,2′-Difluoro-4,4′-diiodo-3,3′-bipyridine (5a) 2-Fluoro-3-iodopyridine (7.80 mmol, 1.74 g) was dissolved in 40 ml of anhydrous THF under nitrogen atmosphere and the solution was cooled in acetone/C02 bath. LDA (1.1 eq., 1.2 M in hexanes-THF, 8.58 mmol, 7.15 ml) was added dropwise. The reaction mixture became yellowish and after stirring for 0.5h it was analyzed by GC/MS. A clean BCHD reaction was confirmed, the mixture was stirred for additional 0.5h and CuCl2 (1.1 eq., 8.58 mmol, 1.15 g) was added in one portion. The yellow reaction mixture became dark blue, then brown red (within 1-2 h) and then light greenish after warm up to room temperature. The reaction mixture was treated with hexanes and water, the organic phase was removed, and the aqueous phase was extracted with hexanes (2 x -20 ml). The combined organic phases were dried over MgS04 and the solvent was removed by rotary evaporation to give greenish- brownish oil which partially solidified on standing. This crude product was purified by column chromatography (200 ml of silica gel, hexanes :CH2C12 mixtures (2: 1, 1 : 1 : and then 1 :2) as eluants). The solvents were removed from combined fractions and the product was obtained as off-white solid (1.04 g, 60.1%). UV-vis (CH2C12) max, nm226, 244, 268. HRMS (EI) calculated for Ci0H4F2I2N2 443.8432; found 443.8417. 1H NMR (CDC13, 400 MHz): delta 8.01 (d, J= 5.2 Hz, 2H), 7.82 (d, J= 5.2 Hz, 2H); 13C{1H} NMR (CDCI3, 100 MHz): delta 159.28 (d, J (C-F) = 242.8 Hz, quaternary C), 148.5 (d, J(C-F) = 15.62 Hz, CH), 132.1 (d, J(C-F) = 4.6 Hz, CH), 125.0 (dd, J (C-F) = 33.4 Hz, 4.1 Hz), 114.5 (d, J(C-F) = 1.7 Hz). Anal. Calc. for Ci0H4F2I2N2: C, 27.05; H, 0.91; N, 6.31. Found: C, 27.52; H, 0.84;

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 113975-22-7, 2-Fluoro-3-iodopyridine.

Reference:
Patent; GEORGIA TECH RESEARCH CORPORATION; GETMANENKO, Yulia A.; MARDER, Seth; HWANG, Do Kyung; KIPPELEN, Bernard; WO2013/23108; (2013); A1;; ; Patent; GEORGIA TECH RESEARCH CORPORATION; GETMANENKO, Yulia A.; MARDER, Seth; HWANG, Do Kyung; KIPPELEN, Bernard; WO2013/23106; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 2942-59-8, 2-Chloronicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2942-59-8, blongs to pyridine-derivatives compound. Recommanded Product: 2942-59-8

EXAMPLE 18 3-Acetyl-2-chloropyridine The following is the preparation of a compound of Formula 2 in which t is 0, L is chloro, Y is N, Z is CH and R3 is acetyl. A mixture of 2-chloronicotinic acid (20 g, 0.127 mmol) and oxalyl chloride (13.3 mL, 0.152 mmol) in 2 drops of DMF and 200 mL of methylene chloride was stirred at room temperature for approximately 14 hours. The mixture was stirred at reflux temperature for 1 hour. The solution was cooled and partitioned between 100 mL of ice-cold aqueous sodium bicarbonate and 300 mL of methylene chloride. The organic layer was washed with brine, dried (Na2 SO4) and concentrated to give 2-chloronicotinic acid chloride (8.8 g, 49.5 mmol). A mixture of 2-chloronicotinic acid chloride (8.8 g, 49.5 mmol), tetramethyltin (5.5 mL, 40 mmol) and bis(benzonitrile)palladium(II) chloride (0.385 g) in 20 mL of hexamethylphosphoramide was stirred at room temperature for 20 hours. The mixture was stirred with 50 mL of 10percent potassium fluoride and then poured into 50 mL of water. The mixture was extracted with diethyl ether (4*50 mL) and the combined extracts were washed with water, saturated sodium bicarbonate and sodium chloride, dried (Na2 SO4) and concentrated. The residue was purified on silica gel by column chromatography eluding with hexanes/ethyl acetate (3:1) to give 3-acetyl-2-chloropyridine (4.2 g, 27 mmol).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2942-59-8, 2-Chloronicotinic acid, and friends who are interested can also refer to it.

Reference:
Patent; Syntex (U.S.A.) Inc.; US5688795; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 573675-25-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 573675-25-9, name is 5-Bromo-3-nitropicolinonitrile, molecular formula is C6H2BrN3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To asolution of tetrabutyl-ammonium fluoride (TBAF, 51.2 g, 197.4 mmol, 1.5eq) in DMF (100 mL), 4 A Molecular sieves powder (30 g) were added. The resulting mixture was stirred for 30 minutes. The mixture was filtered and the filtrate was transferred into a 1000 mL reaction flask. A solution of compound 88 (30 g,131.6 mmol, l .Oe q) in DMF (50 mL) was added to the above solution via a addition funnel over 10 minutes, while maintaining the internal temperature below -15C. After stirring for 20 minutes, 2 N HC1 (60 mL) was added over 5 minutes. After aging for1 hour, the mixture was cooled to 2.5C and filtered. The filtration cake was washed by DMF/water (10% (v/v), 2 x 36 mL). The filtrate was combined and concentrated in vacuo. The resulting residue was re-crystallized from 2-propanol (50 mL) to afford the desired compound 89 (13 g).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 573675-25-9, 5-Bromo-3-nitropicolinonitrile.

Reference:
Patent; TIBOTEC PHARMACEUTICALS; VANDYCK, Koen; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard; WO2012/13643; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem