Pyridine-derivatives

Electric Literature of 799293-85-9, Adding some certain compound to certain chemical reactions, such as: 799293-85-9, name is 3-Bromothieno[3,2-c]pyridin-4-amine,molecular formula is C7H5BrN2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 799293-85-9.

EXAMPLE 10A 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amine A mixture of Example 1B (1.5 g, 6.5 mmol), 4-phenoxyphenylboronic acid (1.53 g, 7.1 mmol) and Na2CO3 (1.81 g, 17.1 mmol) in toluene (26 mL), ethanol (5 mL), and water (10 mL) was purged with nitrogen for 45 minutes, then treated with Pd(PPh3)4 (0.382 g, 0.33 mmol) and heated to 90 C. overnight. The reaction was cooled to room temperature and partitioned between water and ethyl acetate. The aqueous phase was extracted with ethyl acetate twice and the combined organic extracts were washed with brine, dried (Na2SO4), filtered, and concentrated. The residue was purified by flash column chromatography on silica gel with 40% ethyl acetate/hexanes to provide 1.69 g (82% yield) of the desired product. MS (ESI(+)) m/e 318.9 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 799293-85-9, 3-Bromothieno[3,2-c]pyridin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Betschmann, Patrick; Burchat, Andrew F.; Calderwood, David J.; Curtin, Michael L.; Davidsen, Steven K.; Davis, Heather M.; Frey, Robin R.; Heyman, Howard R.; Hirst, Gavin C.; Hrnciar, Peter; Michaelides, Michael R.; Muckey, Melanie A.; Rafferty, Paul; Wada, Carol K.; US2005/43347; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 118289-17-1 ,Some common heterocyclic compound, 118289-17-1, molecular formula is C6H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a 50 mL two-necked flask equipped with magnetic stirrer and condenser was added 2-bromopyridine (1.0 eq), Pd(PPh3)4 (5 mol%), K2CO3 solution (2.0 eq) and toluene under N2 at room temperture. After reacted for 15 min, a solution of the boronic acid (1.2 eq) in EtOH was then added. The reaction mixture was then heated to 95 C and reacted for 4 h. After cooling to room temperature, to the reaction mixture aqueous NH4Cl was added and extracted three times with EtOAc. The organic extracts were then combined, washed with brine, dried with MgSO4 and then concentrated under reduced pressure. The crude product was then purified by silica gel column chromatography(Petroleum ether/EtOAc) to give compounds 1 and 5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,118289-17-1, its application will become more common.

Reference:
Article; Duan, Yingchao; Qin, Wenping; Suo, Fengzhi; Zhai, Xiaoyu; Guan, Yuanyuan; Wang, Xiaojuan; Zheng, Yichao; Liu, Hongmin; Bioorganic and Medicinal Chemistry; vol. 26; 23-24; (2018); p. 6000 – 6014;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 115170-40-6 ,Some common heterocyclic compound, 115170-40-6, molecular formula is C7H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a) 30g (0.151mol) of 5-bromo-7-azaporphyrin, 60g of activated carbon fiber catalyst, 264g of xylene into the reaction flask, stirring evenly, to obtain a reaction mixture G;b) The reaction mixture G at 100 C, oxygen flow 200mL/min, reaction 8h, chromatographic monitoring of the disappearance of raw materials;c) Filtration, filter out activated carbon fiber catalyst, obtain organic layer H, recover solvent, get 5-bromo-7-azaindole crude product, recrystallize from methanol to obtain product 25.37g, yield 85.43%, content ?99% .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 115170-40-6, 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhonggang Group Anshan Heat Energy Institute Co., Ltd.; Wang Haiyang; Wang Shoukai; Xu Zhe; Zhao Wei; Jiang Hui; Jin Dan; Xu Haoran; (7 pag.)CN107987076; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 68963-75-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 68963-75-7, name is 4,6-Dichloropyridin-2(1H)-one. A new synthetic method of this compound is introduced below.

2,4-Dichloro-6-hydroxypyridine (696mg, 4.2mmol), 3-exo-hydroxy-8- azabicyclo[3.2.1]octane-8-carboxylic acid terf-butyl ester (965mg, 4.2mmol) and (4,4- Dimethyl-1 ,1-dioxido-1 ,2,5-thiadiazolidin-2-yl)triphenylphosphonium (4.31g, 10.5mmol) in THF (2OmL) were stirred for 16h. Ethyl acetate (5OmL) and water (2OmL) were added and the organic and aqueous layers were separated. The organic layer was dried over Na2SO4 and concentrated in vacuo. The crude material was then purified by chromatography on silica gel. Elution with 10:90 ethyl acetate:heptane afforded 3-exo-(4,6-dichloropyridin-2- yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid terf-butyl ester (1.29g, 3.6mmol, 82percent). M.S. (ESI) m/z: 373,375 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,68963-75-7, its application will become more common.

Reference:
Patent; N.V. ORGANON; WO2007/63071; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 71902-33-5 , The common heterocyclic compound, 71902-33-5, name is 3,5-Difluoropyridine, molecular formula is C5H3F2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: An oven-dried reaction vessel (4 or 9 ml screw-cap vial) equipped with a stirring bar was allowed to cool to room temperature under vacuum. Activated 4 A molecular sieves (crushed, 50 mg), [Rh-2 ] (and solid substrates, 1.0 equiv.), were added under air. The vial was then depressurized and pressurized with argon gas three times before the addition of dry THF (1 M) (and liquid substrates, distilled over CaH2, 1.0 equiv.). Following the addition of 4,4,5,5-tetramethyl-1,3,2-dioxaborolane (2.0-4.0 equiv. as indicated), the glass vial was placed in a 150 ml stainless-steel autoclave under an argon atmosphere. The autoclave was pressurized and depressurized with hydrogen gas three times before the indicated pressure was set. The reaction mixture was stirred at 25-40 C for 24 h. After the autoclave was carefully depressurized, trifluoroacetic anhydride (3.0 equiv.) and CH2Cl2 (0.5 ml) were added to the crude mixture and stirring was continued for 10 min at room temperature. Alternatively, di-tert-butyl dicarbonate (3.0 equiv.), triethyl amine (3.0 equiv.) and CH2Cl2 (0.5 ml) were added to the reaction mixture and stirring was continued for 2 h at room temperature. The crude was then filtered over fritted funnel and the remaining solid was washed with ethyl acetate (2x 5 ml). The combined solution was concentrated under reduced pressure and submitted to column chromatography (pentane/ethyl acetate or pentane/dichloromethane) to obtain the final product. The indicated diastereoselectivities were determined by GC analysis or from the 19F NMR spectrum immediately after the reaction. NMR yield was calculated using hexafluorobenzene (20 mul, 0.173 mmol) as internal standard.

The synthetic route of 71902-33-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nairoukh, Zackaria; Wollenburg, Marco; Schlepphorst, Christoph; Bergander, Klaus; Glorius, Frank; Nature Chemistry; vol. 11; 3; (2019); p. 264 – 270;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 113770-88-0, Adding some certain compound to certain chemical reactions, such as: 113770-88-0, name is 3-Fluoro-4-cyanopyridine,molecular formula is C6H3FN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 113770-88-0.

Example 15A 1H-Pyrazolo[3,4-c]pyridin-3-amine 3-Fluoro-isonicotinonitrile (0.50 g, 4.10 mmol) was dissolved in ethanol (8 mL) and treated with hydrazine hydrate (0.31 g, 6.1 mmol). After stirring at 70 C. for 16 h, the mixture was cooled to RT and concentrated in vacuo and dried to yield the title compound (0.66 g, 100% of theory). LC-MS (Method 2B): Rt=0.51 min, MS (ESIPos): m/z=135 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 113770-88-0, 3-Fluoro-4-cyanopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; Hassfeld, Jorma; KINZEL, Tom; Koebberling, Johannes; CANCHO GRANDE, Yolanda; BEYER, Kristin; Roehrig, Susanne; Koellnberger, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; US2015/126449; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1065100-83-5, name is (1H-Pyrrolo[2,3-b]pyridin-3-yl)methanol, molecular formula is C8H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: (1H-Pyrrolo[2,3-b]pyridin-3-yl)methanol

To a mixture of 1 H-pyrrolo[2,3-b]pyridin-3-yl)methanol (A-3) (1.0 g, 6.75 mmol) in anhydrous THF (50 mL) were added DPPA (3.71 g, 13.5 mmol) and DBU (0.821 g, 5.4 mmol) respectively. It was refluxed under N2 for 6 h, and then concentrated under vacuo. The resulting residue was dissolved in EtOAc (50 mL), washed with brine, dried over sodium sulfate and concentrated under vacuo, to obtain the crude product. The crude product was purified by chromatography on silica gel to afford the title compound (0.587 g). MS (m/z): 174 (M+1 )+.

With the rapid development of chemical substances, we look forward to future research findings about 1065100-83-5.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; JIA, Hong; DAI, Guangxiu; WO2011/79804; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 150322-38-6, Name is 5-(2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one, formurla is C18H18FNO2S. In a document, author is Mahmoudi, Ghodrat, introducing its new discovery. HPLC of Formula: https://www.ambeed.com/products/150322-38-6.html.

Ligand structure-driven self-assembly of Zn(NCS)(2) with a carbohydrazone ligand: A possible intermediate towards a [2 x2] metallic grid

In this work we have synthesized and characterized a new trinuclear heteroleptic discrete zin.(II) complex [Zn-3(HL)(2) (NCS)(4)], fabricated from a mixture of Zn(NO3)(2) and NaNCS with a symmetric and bulky carbohydrazone derived from carbohydrazide and benzoyl pyridine (H2L). The global structure and shape of complex are dictated by two monodeprotonated ligands HL – each coordinating the same Zn(II) ion through one of the pendant arms in an orthogonal fashion, yielding a distorted octahedral N4O2 coordination environment. The second coordination pocket of both ligands each traps Zn(NCS)(2) species, yielding an N4O coordination environment. The hexa- and pentacoordinated metals are separated by about 4 angstrom and positioned almost at a right angle (similar to 87 degrees) addressed by the orientation of organic ligands. The structure of [Zn-3 (HL)(2) (NCS)(4)] is mimicking grid-like structures and can be considered as a possible intermediate towards a [2 x2] metallic grid. The thiocyanate anions block two of three metal sites that could potentially serve as coordination nodes to fulfil the grid formation. A pair of molecules, arranged about an inversion center, are linked through a pair of (N)C-S center dot center dot center dot pi(Py) noncovalent interactions, which have been rationalized using density functional theory (DFT) calculations, and characterized using the noncovalent interaction plot (NCIplot) index and molecular electrostatic potential (MEP) surface computational tools. (C) 2020 Elsevier B.V. All rights reserved.

If you are hungry for even more, make sure to check my other article about 150322-38-6, HPLC of Formula: https://www.ambeed.com/products/150322-38-6.html.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 198904-85-7, 198904-85-7, Name is tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate, molecular formula is C17H21N3O2, belongs to pyridine-derivatives compound. In a document, author is Zhao, Xinyun, introduce the new discover.

Regioselective synthesis of 2-and 4-diarylpyridine ethers and their inhibitory activities against phosphodiesterase 4B

Two diaryl ether regioisomers of pyridine were prepared through the CuI/TMEDA/Cs2CO3-catalyzed reaction of 2,4-dibromopyridine with phenol derivatives under nitrogen atmosphere. The polar solvent DMSO gave 4-isomer as the major product whereas less polar toluene resulted in 2-isomer as a major product. Structures of regioisomers were confirmed by single crystal X-ray diffraction analysis. 4-regioisomer shows higher biological activity against phosphodiesterase 4B (PDE4B) than that of 2-isomer. Molecular docking simulations revealed that the PDE4B-inhibitory activity difference between the two regioisomers was mainly attributed to the atomic charge difference on the -O- linker. (C) 2019 Elsevier B.V. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 198904-85-7. Recommanded Product: 198904-85-7.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application of 94-44-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 94-44-0, Name is Benzyl nicotinate, SMILES is O=C(OCC1=CC=CC=C1)C2=CN=CC=C2, belongs to pyridine-derivatives compound. In a article, author is Du, H. Y., introduce new discover of the category.

Involvement of putrescine in osmotic stress-induced ABA signaling in leaves of wheat seedlings

To elucidate one mechanism by which putrescine (Put) functions in plant signaling under osmotic stress, Put and ABA contents, and plasma membrane-NADPH oxidase (PM-NOX) activity were detected in wheat seedling leaves. Under osmotic stress, ABA and Put contents, PM-NOX activity, and PM-NOX-dependent O2.- production all increased. The inhibitor tungstate (T) of ABA bio-synthesis reduced the increases in ABA and Put contents under osmotic stress. The inhibitor D-arginine (D-Arg) of Put bio-synthesis didn’t reduce osmotic-induced increase of ABA, but it inhibited the increases of PM-NOX activity and O2. – production, and the inhibitory effects were reversed by exogenous Put. These findings suggested that ABA might regulate Put biosynthesis, and Put might regulate PM-NOX activity. Treatments with three inhibitors imidazole (I), diphenylene iodonium (DPI) and pyridine (P) of PM-NOX reduced significantly not only O2. – production, but also the stress-induced increase of Put content, which indicated that O2. – production might regulate Put biosynthesis. Treatments with EGTA (Ca2+ chelator), La3+ and verapamil (V) (Ca2+ channel blockers) reduced significantly the stress-induced increase of Put content, which suggested that Ca2+ might regulate Put biosynthesis. With these findings, it could be concluded that Put was involved in ABA signaling induced by osmotic stress via regulating PM-NOX activity in wheat seedling leaves.

Application of 94-44-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 94-44-0.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem