Pyridine-derivatives

Held, Katharina published the artcilePharmacological properties of TRPM3 isoforms are determined by the length of the pore loop, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is British Journal of Pharmacology (2022), 179(14), 3560-3575, database is CAplus and MEDLINE.

Background and Purpose : Transient receptor potential melastatin 3 (TRPM3) is a non-selective cation channel that plays a pivotal role in the peripheral nervous system as a transducer of painful heat signals. Alternative splicing gives rise to several TRPM3 variants. The functional consequences of these splice isoforms are poorly understood. Here, the pharmacol. properties of TRPM3 variants arising from alternative splicing in the pore-forming region were compared. Exptl. Approach : Calcium microfluorimetry and patch clamp recordings were used to compare the properties of heterologously expressed TRPM3α1 (long pore variant) and TRPM3α2-α6 (short pore variants). Furthermore, site-directed mutagenesis was done to investigate the influence of the length of the pore loop on the channel function. Key Results : All short pore loop TRPM3α variants (TRPM3α2-α6) were activated by the neurosteroid pregnenolone sulfate (PS) and by nifedipine, whereas the long pore loop variant TRPM3α1 was insensitive to either compound In contrast, TRPM3α1 was robustly activated by clotrimazole, a compound that does not directly activate the short pore variants but potentiates their responses to PS. Clotrimazole-activated TRPM3α1 currents were largely insensitive to established TRPM3α2 antagonists and were only partially inhibited upon activation of the μ opioid receptor. Finally, by creating a set of mutant channels with pore loops of intermediate length, we showed that the length of the pore loop dictates differential channel activation by PS and clotrimazole. Conclusion and Implications : Alternative splicing in the pore-forming region of TRPM3 defines the channel’s pharmacol. properties, which depend critically on the length of the pore-forming loop.

British Journal of Pharmacology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bagley, Mark C. published the artcileRapid Protium-Deuterium Exchange of 4-Aminopyridines in Neutral D₂O under Microwave Irradiation, Recommanded Product: 4-Amino-2-picoline, the publication is Synlett (2016), 27(17), 2467-2472, database is CAplus.

4-Aminopyridines underwent rapid and highly selective H/D exchange at C-2 and C-6 in neutral D₂O upon microwave irradiation at only 190° for two hours in a sealed vessel. This method contrasted and complemented the acid-mediated H/D exchange, required no catalyst, and was appropriate for the synthesis of deuterium isotopologues of N- and C-substituted 4-aminopyridines and other nitrogen heterocycles.

Synlett published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Recommanded Product: 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Singh, Rahul published the artcileNickel-Catalyzed C-S Bond Formation: Synthesis of Aryl Sulfides from Arylsulfonyl Hydrazides and Boronic Acids, Computed Properties of 197958-29-5, the publication is Advanced Synthesis & Catalysis (2015), 357(6), 1181-1186, database is CAplus.

A practical nickel-catalyzed approach for the C-S bond formation through the cross-coupling of arylsulfonyl hydrazides RSO₂NHNH₂ [R = CH₃(CH₂)₇, C₆H₅, 4-O₂NC₆H₄, etc.] and aryl boronic acids R¹B(OH)₂ (R¹ = naphthalen-2-yl, 4-ClC₆H₄, pyridin-2-yl, etc.) has been developed. The report employs arylsulfonyl hydrazide as an aryl thiol equivalent and offers a mild and eco-safe synthesis of unsym. thioethers RSR¹ in good to excellent yields in air. The scope and versatility of the method has been successfully demonstrated with 22 examples.

Advanced Synthesis & Catalysis published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C17H16O2, Computed Properties of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Haddad, P. R. published the artcileSpectrophotometric and fluorometric determination of cobalt, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Talanta (1976), 23(4), 275-81, database is CAplus and MEDLINE.

Co(II) reacts with pyridine-2-aldehyde-2-pyridyl hydrazone (L) and eosine (L1) at pH 5.6 to give the ternary complex CoL(HL)L12 which is extracted by CHCl3-Me2CO (7:3) to give a strongly colored, fluorescent extract Linear calibration curves for absorption at 547 nm and fluorescence at 558 nm were obtained for 0.04-0.4 and 0.02-0.2 ppm Co, resp. Relative standard deviations were 2.2 and 6.1% and detection limits were 0.017 and 0.008 ppm Co for absorption and fluorescence, resp. Interferences from Cu(II) were eliminated by electrodeposition of Cu and from Ni, Fe(II), Pd(II), and Hg(II) by ion exchange, giving recoveries of >98%. The method was successfully applied to determination of Co in steels.

Talanta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tavares, Ana Beatriz M. L. A. published the artcileA Quantum Chemistry Approach of Breast Cancer Drugs Bound to Human Serum Albumin, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Advanced Theory and Simulations (2022), 5(5), 2100464, database is CAplus.

The bindings of three different anticancer drugs, Cu(BpT)Br (2-benzoylpyridine thiosemicarbazone copper), NAMI-A (imidazolium trans-imidazoledimethylsulfoxide-tetrachlorido ruthenate), and DOX (doxorubicin), widely used in the breast cancer treatment, to human serum albumin (HSA) are investigated using a quantum chem. approach based on the d. functional theory calculations employing a dispersion corrected exchange-correlation functional within a fragmentation strategy. As a consequence, it is possible to identify the magnitude of the most relevant quantum binding interactions of these supramol. complexes, and thus guide their mol. modification process. The data obtained in this work highlight the power of quantum calculations as an important tool for the drug design process, and pave the way for the use of HSA-ligand interactions during the rational design of new anticancer compounds More important, the results show that HSA/multi-drug complex, formed by the combination of the three individual anticancer drugs [Cu(BpT)Br]-(NAMI-A)-(DOX), increases the targeting ability compared with each single drugs interaction with HSA, in agreement with in vivo predictions.

Advanced Theory and Simulations published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is CBF6K, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Brecklinghaus, Tim published the artcileThe hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds, COA of Formula: C17H18N2O6, the publication is Chemico-Biological Interactions (2022), 109728, database is CAplus and MEDLINE.

An in vitro/in silico method that determines the risk of human drug induced liver injury in relation to oral doses and blood concentrations of drugs was recently introduced. This method utilizes information on the maximal blood concentration (Cmax) for a specific dose of a test compound, which can be estimated using physiol.-based pharmacokinetic modeling, and a cytotoxicity test in cultured human hepatocytes. In the present study, we analyzed if the addition of an assay that measures the inhibition of bile acid export carriers, like BSEP and/or MRP2, to the existing method improves the differentiation of hepatotoxic and non-hepatotoxic compounds Therefore, an export assay for 5-chloromethylfluorescein diacetate (CMFDA) was established. We tested 36 compounds in a concentration-dependent manner for which the risk of hepatotoxicity for specific oral doses and the capacity to inhibit hepatocyte export carriers are known. Compared to the CTB cytotoxicity test, substantially lower EC10 values were obtained using the CMFDA assay for several known BSEP and/or MRP2 inhibitors. To quantify if the addition of the CMFDA assay to our test system improves the overall separation of hepatotoxic from non-hepatotoxic compounds, the toxicity separation index (TSI) was calculated We obtained a better TSI using the lower alert concentration from either the CMFDA or the CTB test (TSI: 0.886) compared to considering the CTB test alone (TSI: 0.775). In conclusion, the data show that integration of the CMFDA assay with an in vitro test battery improves the differentiation of hepatotoxic and non-hepatotoxic compounds in a set of compounds that includes bile acid export carrier inhibitors.

Chemico-Biological Interactions published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, COA of Formula: C17H18N2O6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hosseini-Sarvari, Mona published the artcileVisible-light assisted of nano Ni/g-C₃N₄ with efficient photocatalytic activity and stability for selective aerobic C-H activation and epoxidation, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Journal of Organometallic Chemistry (2020), 121549, database is CAplus.

A selective, economical, and ecol. protocol has been described for the oxidation of Me arenes and their analogs ArCH₂R (Ar = 3-nitrophenyl, 1-naphthyl, furan-2-yl, etc.; R = H, Me, Ph, pyridin-2-yl) and 9H-fluorene to the corresponding carbonyl compounds ArC(O)R and 9H-fluoren-9-one and epoxidation reactions of alkenes, e.g., 1,3-cyclohexadiene with mol. oxygen (O₂) or air as a green oxygen source, under mild reaction conditions. The nano Ni/g-C₃N₄ exhibited high photocatalytic activity, stability, and selectivity in the C-H activation of Me arenes, methylene arenes, and epoxidation of various alkenes under visible-light irradiation without the use of an oxidizing agent and under base free conditions.

Journal of Organometallic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dropinski, James F. published the artcileSynthesis and biological activities of novel arylindole-2-carboxylic acid analogs as PPARγ partial agonists, Name: (4-(Trifluoromethyl)pyridin-2-yl)boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(22), 5035-5038, database is CAplus and MEDLINE.

A series of novel arylindole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chem. synthesis and in vitro activities are discussed. The indole I was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.

Bioorganic & Medicinal Chemistry Letters published new progress about 870459-90-8. 870459-90-8 belongs to pyridine-derivatives, auxiliary class Trifluoromethyl,Pyridine,Fluoride,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is (4-(Trifluoromethyl)pyridin-2-yl)boronic acid, and the molecular formula is C6H5BF3NO2, Name: (4-(Trifluoromethyl)pyridin-2-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kiani, Adeleh published the artcileDirect synthesis of sulfonyl azides from sulfonic acids, Application In Synthesis of 636-73-7, the publication is Journal of Sulfur Chemistry (2014), 35(2), 119-127, database is CAplus.

A one-pot process for the synthesis of various sulfonyl azides (RSO₂N₃) by treating sulfonic acids with PPh₃-trichloroisocyanuric acid-sodium azide at room temperature was described. A wide range of arenesulfonyl and alkanesulfonyl azides was obtained in excellent yields under mild conditions.

Journal of Sulfur Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application In Synthesis of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Iwasawa, Tetsuo published the artcileExperimental and Computational Probes of a Self-Assembled Capsule, Synthetic Route of 85237-71-4, the publication is Organic Letters (2006), 8(14), 2925-2928, database is CAplus and MEDLINE.

This research was undertaken to explore the interior surface of a synthetic receptor 1.1 with arylpyridines as guests. The interior surface differentiates the guests through the recognition of their nitrogen atoms. Exptl. and computational analyses revealed that there is a delicate balance of attractions and repulsions between the host and the lone pairs of guests.

Organic Letters published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Synthetic Route of 85237-71-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem