Pyridine-derivatives

Theoretical Explanation of Reaction Site Selectivity in the Addition of a Phenoxy Group to Perfluoropyridine was written by Fuhrer, Timothy J.;Houck, Matthew;Corley, Cynthia A.;Iacono, Scott T.. And the article was included in Journal of Physical Chemistry A in 2019.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

Pentafluoropyridine, a potentially useful precursor in organofluorine methodol., undergoes selective substitution of a fluorine with a phenoxide at the site para to the nitrogen. Subsequent aryloxide substitutions can be accomplished at the ortho-positions with aryloxide groups containing various functional groups para to the phenoxide oxygen. During this phase of the reaction, “reverse reactions” involving substitutions of the original para substituent with a free fluoride or with another aryloxide moiety are observed with a frequency that depends on the functional group para to the oxygen on the aryloxide. Herein, we provide a theor. explanation of these observations through use of d. functional theory. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application In Synthesis of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reverse Arene Sandwich Structures Based upon 蟺-Hole路路路[M(II)] (d⁸ M = Pt, Pd) Interactions, where Positively Charged Metal Centers Play the Role of a Nucleophile was written by Rozhkov, Anton V.;Krykova, Mariya A.;Ivanov, Daniil M.;Novikov, Alexander S.;Sinelshchikova, Anna A.;Volostnykh, Marina V.;Konovalov, Mikhail A.;Grigoriev, Mikhail S.;Gorbunova, Yulia G.;Kukushkin, Vadim Yu.. And the article was included in Angewandte Chemie, International Edition in 2019.Formula: C5F5N The following contents are mentioned in the article:

[Pt(tpp)] (H₂tpp = tetraphenylporphyrin), [M(acac)₂] (M = Pd, Pt, Hacac = acetylacetone), and [Pd(ba)₂] (Hba = benzoylacetone) were co-crystallized with highly electron-deficient arene systems to form reverse arene sandwich structures built by 蟺-hole-[M(II)] (d⁸M = Pt, Pd) interactions. [Pt(tpp)]路2C₆F₆ is monomeric, whereas the diketonate 1:1 adducts form columnar infinity 1-dimensional-stack assembled by simultaneous action of both 蟺-hole-[M(II)] and C-F interactions. The reverse sandwiches are based on noncovalent interactions and calculated ESP distributions indicate that in 蟺-hole-[M(II)] contacts, [M(II)] plays the role of a nucleophile. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Formula: C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and Reactivity of a Low-Coordinate Iron(II) Hydride Complex: Applications in Catalytic Hydrodefluorination was written by Hein, Nicholas M.;Pick, Fraser S.;Fryzuk, Michael D.. And the article was included in Inorganic Chemistry in 2017.Application of 700-16-3 The following contents are mentioned in the article:

A low-coordinate iron hydride complex bearing an unsym. NpN (enamido-phosphinimine) ligand scaffold was synthesized and fully characterized. Insertion reactivity with azobenzene, 3-hexyne, and 1-azidoadamantane was explored, and the isolated products were analogous to previously reported 尾-diketiminate iron hydride insertion products. Surprisingly, the NpN iron hydride displays unprecedented reactivity toward hexafluorobenzene, affording an NpN iron fluoride complex and pentafluorobenzene as products. The NpN iron hydride is a precatalyst for catalytic hydrodefluorination of perfluorinated aromatics in the presence of silane. Kinetic studies indicated that the rate-determining step during catalysis involved silane. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bare Magnetite-Promoted Oxidative Hydroxylation of Arylboronic Acids and Subsequent Conversion into Phenolic Compounds was written by Cho, Hyun-A.;Lee, Yong-Ki;Kim, Seung-Hoi. And the article was included in Synlett in 2022.Recommanded Product: 700-16-3 The following contents are mentioned in the article:

The simple combination of readily available, recoverable, and recyclable magnetite (Fe₃O₄) nanoparticles and an environmentally friendly oxidant (H₂O₂) induced oxidative hydroxylation of arylboronic acids into their corresponding phenols ArOH [Ar = Ph, 2-MeC₆H₄, 4-MeC₆H₄, etc.] under mild conditions. Moreover, subsequent arylation or alkylation of intermediate with appropriate electrophiles was accomplished in a one-pot system, leading to the formation of halophenols and phenolic derivs ArOR [Ar = Ph, 3-MeC₆H₄, 4-MeC₆H₄, etc.; R = Bn, CH₂(4-FC₆H₄), allyl, etc]. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Recommanded Product: 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and Photophysical Properties of N-Arylated Diketopyrrolopyrroles was written by Gutkowski, Krzysztof;Azarias, Cloe;Banasiewicz, Marzena;Kozankiewicz, Boleslaw;Jacquemin, Denis;Gryko, Daniel T.. And the article was included in European Journal of Organic Chemistry in 2018.SDS of cas: 700-16-3 The following contents are mentioned in the article:

The N-arylation of diketopyrrolopyrroles with aryl fluorides free of nitro groups was successfully achieved for the first time. Diketopyrrolopyrroles possessing 3,4-dimethoxyphenyl and benzofuryl substituents underwent reaction with, for example, pentafluoropyridine, in the presence of K₂CO₃ in N-methyl-2-pyrrolidone to give the desired products in moderate yields. Their photophys. properties in solution were found not to differ significantly from those of analogous N-alkylated diketopyrrolopyrroles, whereas in contrast to the latter compounds, they were found to possess fluorescence in the solid state. The photophys. properties of all compounds were rationalized by using time-dependent d. functional theory. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3SDS of cas: 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Transition-Metal-Free Coupling of Polyfluorinated Arenes and Functionalized, Masked Aryl Nucleophiles was written by Finck, Lucie;Oestreich, Martin. And the article was included in Chemistry – A European Journal in 2021.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

A chemoselective C(sp²)-C(sp²) coupling of sufficiently electron-deficient fluorinated arenes and functionalized N-aryl-N’-silyldiazenes as masked aryl nucleophiles is reported. The fluoride-promoted transformation involves the in situ generation of the aryl nucleophile decorated with various sensitive functional groups followed by a stepwise nucleophilic aromatic substitution (S_NAr). These reactions typically proceed at room temperature within minutes. This catalytic process allows for the functionalization of both coupling partners, furnishing highly fluorinated biaryls in good yields. Thus, e.g., diazene I + hexafluorobenzene 鈫?II (92%, 79% isolated) in presence of CsF in DMF. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application In Synthesis of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

MOF-Derived Nanocobalt for Oxidative Functionalization of Cyclic Amines to Quinazolinones with 2-Aminoarylmethanols was written by Xie, Feng;Chen, Qing-Hua;Xie, Rong;Jiang, Huan-Feng;Zhang, Min. And the article was included in ACS Catalysis in 2018.Computed Properties of C6H8N2O The following contents are mentioned in the article:

By employing a MOF-templated method, we have developed a highly dispersed and ultralow loading cobalt nanocatalyst, which has been applied in the oxidative functionalization of easily available cyclic amines with 2-aminoarylmethanols to ring-fused quinazolinones, the core structures of numerous valuable products. The developed catalytic transformation proceeds with the merits of broad substrate scope, good functional group tolerance and chemoselectivity, high step- and atom-efficiency, and use of the naturally abundant Co/O₂ system, which offers a practical way for the preparation of quinazolinones with structural diversity. The work presented has built an important basis for direct conversion of cyclic amine motifs into functional frameworks. This study involved multiple reactions and reactants, such as (3-Aminopyridin-2-yl)methanol (cas: 52378-63-9Computed Properties of C6H8N2O).

(3-Aminopyridin-2-yl)methanol (cas: 52378-63-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Computed Properties of C6H8N2O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Photoredox-Controlled Mono- and Di-Multifluoroarylation of C(sp³)-H Bonds with Aryl Fluorides was written by Xie, Jin;Rudolph, Matthias;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in Angewandte Chemie, International Edition in 2017.Synthetic Route of C5F5N The following contents are mentioned in the article:

A controllable mono- and di-multifluoroarylation of acyclic and cyclic N-aryl amines with aryl fluorides by photocatalyzed dual C(sp³)-H/C(sp²)-F functionalization has been developed, providing new access to a wide array of valuable 伪-fluoroarylated amines. In addition, the one-pot consecutive hetero-di-multifluoroarylation of N-aryl pyrrolidines and N,N-dimethylanilines was achieved with high to excellent diastereoselectivity. This new defluorinative C(sp³)-C(sp²) coupling is distinguished by a broad scope, good regioselectivity, and mild conditions as well as gram-scale and late-stage applicability, and thus constitutes a significant advance in the arylation of unactivated C(sp³)-H bonds with aryl fluorides. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Synthetic Route of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Synthetic Route of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Protecting Group-Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions was written by Brittain, William D. G.;Cobb, Steven L.. And the article was included in Journal of Organic Chemistry in 2020.Product Details of 700-16-3 The following contents are mentioned in the article:

Being able to utilize a protecting group to influence remote regiocontrol offers a simple alternative approach to direct late-stage functionalization of complex organic mols. However, protecting groups that have the ability to influence reaction regioselectivity remote to their local chem. environment are not widely reported in the literature. Herein, we report the development of remote regioselective electrophilic aromatic substitution (S_EAr) reactions that are enabled via the application of the tetrafluoropyridyl (TFP) phenol-protecting group. We demonstrate that through sequential reactions and protection/deprotection of the TFP group, substitution patterns that do not conform to classical S_EAr regioselectivity rules can be readily accessed. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Product Details of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ni-catalyzed regio- and stereo-defined intermolecular cross-electrophile dialkylation of alkynes without directing group was written by Zhan, Yi-Zhou;Xiao, Nan;Shu, Wei. And the article was included in Nature Communications in 2021.Reference of 700-16-3 The following contents are mentioned in the article:

The nickel-catalyzed intermol. cross-dialkylation of alkynes devoid of directing or activating groups afforded multiple aliphatic substituted alkenes in a syn-selective fashion at room temp was reported. The combination of two-electron oxidative cyclometallation and single-electron cross-electrophile coupling of nickel enabled the syn-cross-dialkylation of alkynes at room temperature This reductive protocol enabled the sequential installation of two different alkyl substituents onto alkynes in a regio- and stereo-selective manner, circumvented the tedious preformation of sensitive organometallic reagents. The synthetic utility of this protocol was demonstrated by efficient synthesis of multi-substituted unfunctionalized alkenes and diverse transformations of the product. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Reference of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Reference of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem