Pyridine-derivatives

《Chemoselective Synthesis of 1,1-Disubstituted Vinyl Triflates from Terminal Alkynes Using TfOH in the Presence of TMSN3》 was written by Tummatorn, Jumreang; Punjajom, Kunlayanee; Rodphon, Warabhorn; Ruengsangtongkul, Sureeporn; Chaisan, Nattawadee; Lumyong, Kanyapat; Thongsornkleeb, Charnsak; Nimnual, Phongprapan; Ruchirawat, Somsak. Quality Control of 4-EthynylpyridineThis research focused onvinyl triflate regioselective chemoselective preparation; terminal alkyne regioselective chemoselective triflation triflic acid silyl azide; hydrazoic acid generated triflation toxic explosive. The article conveys some information:

1,1-Disubstituted vinyl triflates were prepared chemoselectively and regioselectively by direct hydrotriflation of terminal alkynes with TfOH and TMSN3 in DCM at room temperature; internal alkynes did not react under these conditions. Aryl alkynes with both terminal and internal alkyne moieties reacted only at their terminal alkyne moieties. Hydrazoic acid generated in situ in the triflation reaction is toxic and potentially explosive; the reactions should be performed in a well-ventilated fume hood.4-Ethynylpyridine(cas: 2510-22-7Quality Control of 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Quality Control of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Four congenetic zinc(II) MOFs from delicate solvent-regulated strategy: Structural diversities and fluorescent properties》 was written by Wen, Gui-Lin; Liu, Bo; Liu, Dao-Fu; Wang, Feng-Wu; Li, Li; Zhu, Liang; Song, Dong-Mei; Huang, Chao-Xiu; Wang, Yao-Yu. COA of Formula: C5H3Br2NThis research focused onzinc carboxylphenyl pyridine MOF preparation crystal structure thermal stability; fluorescence zinc carboxylphenyl pyridine MOF. The article conveys some information:

Four new congenetic zinc(II) MOFs, namely [Zn5(bdcpp)3(DMF)(H2O)4]n·x(solvent) (1), [Zn2(bdcpp)(Hbdcpp)]n·y(solvent) (2), [Zn2(bdcpp)(DMF)(H2O)2]n (3), and [Zn2(bdcpp)(NMP)(H2O)2]n (4) (H4bdcpp = 2,6-bis(2′,4′-dicarboxylphenyl)pyridine, DMF = N,N’-dimethylformamide, NMP = N-methyl-2-pyrrolidone), were synthesized solvothermally with different solvent systems. Stabilized by Zn2(COO)4 paddle-wheel building blocks, the resulting MOFs 1-4 represent diverse structural features. Structurally, 1 is a rarely 3,4-c binodal 2D bilayered framework, 2 possesses a 4-c 2D (4,4) sql planar network accommodating two kinds of hetero chiral helix chains, 3 and 4 are isostructural 1D loop ladder chains except different solvent mols. occupying the axial terminals of Zn2(COO)4 paddle-wheels. This approach based on solvent-regulated strategy aiming to allow the structural fine-tuning provides a good role model in reticular chem. Complexes 1-3 display excellent solid-state photoluminescence stemming from the metal-to-ligand charge transfer or intraligand charge transmission. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1COA of Formula: C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.COA of Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heterogeneous palladium-catalysed intramolecular C(sp3)-H α-arylation for the green synthesis of oxindoles》 was written by Salameh, Nihad; Anastasiou, Ioannis; Ferlin, Francesco; Minio, Francesco; Chen, Shaomin; Santoro, Stefano; Liu, Ping; Gu, Yanglong; Vaccaro, Luigi. Formula: C5H5BrN2 And the article was included in Molecular Catalysis on April 30 ,2022. The article conveys some information:

The development of a waste-minimized protocol for the synthesis of oxindoles I [R = H, Me; R1 = Me, Et, Bn; R2 = H, Me, F; R3 = H, F, Me, CF2; R4 = H, Me, Cl, CN, etc.; R5 = CH, N] using cyclopentyl Me ether (CPME) as a safe and green reaction medium and palladium on carbon (Pd/C) as a reusable catalyst was presented. This protocol is efficiently applied to a variety of substrates 2-R2-3-R3-4-R4-5-R5-6-X-C6N(R1)C(O)CH3 [X = Br, Cl] affording products I with excellent yields, minimal metal contamination and min. waste production The catalyst was recovered and reused for four consecutive runs without any apparent loss of efficiency. Moreover, products I were isolated by simple precipitation from heptane with no need for chromatog. separations, and both CPME and heptane were recovered. Waste-minimization is reflected by the low E-factor calculated for the presented protocol. In the experiment, the researchers used many compounds, for example, 2-Bromopyridin-3-amine(cas: 39856-58-1Formula: C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Selective approach to N-substituted tertiary 2-pyridones》 was written by Wang, Yu; Xu, Yaoyao; Khan, Shahid; Zhang, Zhunjie; Khan, Ajmal. Product Details of 197958-29-5This research focused onvinyl cyclic carbonate hydroxypyridine palladium catalyst regioselective enantioselective amination; allyl pyridone preparation. The article conveys some information:

The regio- and enantioselective amination of readily available vinyl cyclic carbonates with ambivalent 2-hydroxypyridines was achieved using a Pd(0)/DACH-naphthyl catalyst system. The reaction proceeded under simple conditions, providing access to chiral N-substituted 2-pyridones that bear elusive tertiary carbon centers. A significant drawback previously related to making these products via transition metal-catalyzed allylic substitution procedures was overcome by this catalytic method. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5Product Details of 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Product Details of 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of Diethynyltriptycene-Linked Dipyridyl Ligands》 was written by Kodanko, Jeremy J.; Morys, Anna J.; Lippard, Stephen J.. Recommanded Product: 29682-15-3This research focused ontriptycene pyridylethynyl preparation dinucleating ligand; pyridine bromo dual Sonogashira coupling diethynyltriptycene. The article conveys some information:

An efficient route to a new family of dinucleating ligands has been developed. A convergent strategy to these ligands involved dual Sonogashira cross-coupling of 2,3-diethynyltriptycene with a variety of functionally diverse 5-bromopyridines. The resultant ligands were accessed in four steps and 40-50% overall yields from 1,2,4,5-tetrabromobenzene. Synthesis of an imidazole and a quinoline derivative by this method is also described. The results came from multiple reactions, including the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of perfluoroalkylated bipyridines – new ligands for oxidation reactions under fluorous triphasic conditions》 was written by Quici, Silvio; Cavazzini, Marco; Ceragioli, Silvia; Montanari, Fernando; Pozzi, Gianluca. Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine And the article was included in Tetrahedron Letters on April 30 ,1999. The article conveys some information:

Fluorous soluble bipyridines bearing two perfluoroalkylated side chains in the 6,6′- or 4,4′-positions have been prepared in good yields via etherification of 6,6′-bis(chloromethyl)-2,2′-bipyridine or C-alkylation of 4,4′-dimethyl-2,2′-bipyridine. The new ligands L exhibit amphiphilic behavior with respect to certain fluorous-organic biphasic systems. Nevertheless, their ruthenium complexes (RuLn)X generated in situ are efficient catalysts for the epoxidation of trans-stilbene in a fluorous triphasic system CH2Cl2/H2O/C8F18 in the presence of NaIO4. The fluorous phase, where (RuLn)X is trapped, can be used up to four times without major loss of catalytic activity. In addition to this study using 4,4′-Bis(chloromethyl)-2,2′-bipyridine, there are many other studies that have used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine) was used in this study.

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 116383-98-3On May 7, 1999 ,《Selective palladium-catalyzed carbonylations of dichloroquinoline and simple dichloropyridines》 appeared in Tetrahedron Letters. The author of the article were Najiba, Douja; Carpentier, Jean-Francois; Castanet, Yves; Biot, Christophe; Brocard, Jacques; Mortreux, Andre. The article conveys some information:

Dichloroquinoline and some dichloropyridines undergo selective alkoxycarbonylation in the presence of carbon monoxide, an alc. and PdCl2(PPh3)2 as a catalyst, affording chloro-monoester and/or diesters in good yields under selected reaction conditions. In addition to this study using Methyl 3-chloropicolinate, there are many other studies that have used Methyl 3-chloropicolinate(cas: 116383-98-3HPLC of Formula: 116383-98-3) was used in this study.

Methyl 3-chloropicolinate(cas: 116383-98-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 116383-98-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C12H10Cl2N2On November 24, 2010 ,《Convenient synthesis of functionalized 4,4′-disubstituted-2,2′-bipyridine with extended π-system for dye-sensitized solar cell applications》 appeared in Tetrahedron Letters. The author of the article were Klein, Cedric; Baranoff, Etienne; Nazeeruddin, Khaja Md.; Graetzel, Michael. The article conveys some information:

Exploration of new ruthenium-based sensitizers for dye-sensitized solar cell (DSC) applications required an easy access to multifunctionalized ligands for efficient screening of sensitizers’ properties. Based on the Horner-Wadsworth-Emmons reaction, a convenient synthetic route for the extension of the π-system on 4,4′-disubstituted-2,2′-bipyridines was used to develop a novel series of functionalized 2,2′-bipyridine ligands, e.g., I (R = CO2C6H13, CO2C8C17, OC6H13, OC8H17), with either electron-withdrawing or donating end-capping groups. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Computed Properties of C12H10Cl2N2)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Computed Properties of C12H10Cl2N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gawinecki, Ryszard; Rasala, Danuta; Obrzut, Jan; Tamasik, Piotr published their research in Chemica Scripta on December 31 ,1985. The article was titled 《The ortho effect in pyridines. VI. Singlet → singlet π → π* excited state of 2- and 4-substituted 3-nitropyridines》.Application In Synthesis of 3-Nitroisonicotinic acid The article contains the following contents:

The UV absorption spectra in ethanol were measured for o-substituted nitrobenzenes, 2-substituted-3-nitropyridines and 4-substituted-3-nitropyridines. Based on bathochromic shift of the ICT band and its intensity, the ortho effect is discussed in the singlet→singlet π→π* excited state of investigated compounds In the experiment, the researchers used 3-Nitroisonicotinic acid(cas: 59290-82-3Application In Synthesis of 3-Nitroisonicotinic acid)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Application In Synthesis of 3-Nitroisonicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Hydrogen bond-induced abrupt spin crossover behaviour in 1-D cobalt(II) complexes – the key role of solvate water molecules》 were Zenno, Hikaru; Kobayashi, Fumiya; Nakamura, Masaaki; Sekine, Yoshihiro; Lindoy, Leonard F.; Hayami, Shinya. And the article was published in Dalton Transactions in 2021. Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine The author mentioned the following in the article:

The magnetic properties and structural aspects of the 1-D cobalt(II) complexes, [Co(pyterpy)Cl2]·2H2O (1·2H2O; pyterpy = 4′-(4”’-pyridyl)-2,2′:6′,2”-terpyridine) and [Co(pyethyterpy)Cl2]·2H2O (2·2H2O; pyethyterpy = 4′-((4”’-pyridyl)ethynyl)-2,2′:6′,2”-terpyridine) are reported. In each complex the central cobalt(II) ion displays an octahedral coordination environment composed of three nitrogen donors from the terpyridine moiety, a nitrogen donor from a pyridyl group and two chloride ligands which occupy the axial sites. 1·2H2O exhibits abrupt spin-crossover (SCO) behavior (T1/2↓ = 218 K; T1/2↑ = 227 K) along with a thermal hysteresis loop, while 2·2H2O and the dehydrated species 1 and 2 exhibit high-spin (HS) states at 2-300 K as well as field-induced single-mol. magnet (SMM) behavior attributed to the presence of magnetic anisotropic HS cobalt(II) species (S = 3/2). 1·2H2O exhibited reversible desorption/resorption of its two water mols., revealing reversible switching between SCO and SMM behavior triggered by the dehydration/rehydration processes. Single crystal x-ray structural analyses revealed that 1·2H2O crystalizes in the orthorhombic space group Pcca while 2 and 2·2H2O crystallize in the monoclinic space group P2/n. Each of the 1-D chains formed by 1·2H2O in the solid state are bridged by hydrogen bonds between water mols. and chloride groups to form a 2-D layered structure. The water mols. bridging 1-D chains in 1·2H2O interact with the chloride ligands occupying the axial positions, complementing the effect of Jahn-Teller distortion and contributing to the abrupt SCO behavior and associated stabilization of the LS state. In the experiment, the researchers used many compounds, for example, 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridineThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem