Pyridine-derivatives

Product Details of 141-86-6In 2021 ,《6-Amino-7-azaindole synthesis from 2,6-diaminopyridine and diols》 appeared in Tetrahedron Letters. The author of the article were Bou-Puerto, Amelia; Bellezza, Delia; Martinez-Morro, Carlota; Gonzalez-Sanchis, Nerea; Ballesteros, Rafael; Cunat, Ana C.; Ballesteros-Garrido, Rafael. The article conveys some information:

6-Amino-7-azaindoles were prepared by dehydrogenative condensation of 2,6-diaminopyridine with diols. In addition, the similar reactions of 2-aminopyridines gave the corresponding pyrrolo[3,2-b]pyrroles. All these transformations were performed using accessible heterogeneous catalysts (Pd/C and ZnO).2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C12H13N3In 2019 ,《Development of radiolabeled bis(zinc(II)-dipicolylamine) complexes for cell death imaging》 appeared in Annals of Nuclear Medicine. The author of the article were Aoki, Miho; Odani, Akira; Ogawa, Kazuma. The article conveys some information:

The present study aimed to develop novel radiolabeled ZnDPA derivatives for cell death imaging in tumor after treatment with anticancer drugs. Methods: [125I]IB-EG2-ZnDPA and [99mTc]Tc-MAG3-EG2-ZnDPA were designed and prepared Results: The radiochem. purities of [125I]IB-EG2-ZnDPA and [99mTc]Tc-MAG3-EG2-ZnDPA exceeded 95%. Although [125I]IB-EG2-ZnDPA gradually decomposing with time, more than 90% of [99mTc]Tc-MAG3-EG2-ZnDPA remained in its intact form in phosphate buffer through 6 h of incubation. Neither [125I]IB-EG2-ZnDPA nor [99mTc]Tc-MAG3-EG2-ZnDPA decomposed so much after 6-h incubation in murine plasma. [125I]IB-EG2-ZnDPA could not specifically recognize PS on the cell surface because of its high lipophilicity. Conversely, [99mTc]Tc-MAG3-EG2-ZnDPA accumulated in cancer cells after treatment with an anticancer drug both in vitro and in vivo, and its accumulation was correlated with the number of TUNEL-pos. cells. However, the biodistribution of [99mTc]Tc-MAG3-EG2-ZnDPA was not suitable for imaging because of its low accumulation in tumor and high uptake in abdomen organs. The experimental process involved the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0COA of Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.COA of Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4-CyanopyridineIn 2021 ,《Can We Identify the Salt-Cocrystal Continuum State Using XPS?》 was published in Crystal Growth & Design. The article was written by Tothadi, Srinu; Shaikh, Tabrez Rafique; Gupta, Sharad; Dandela, Rambabu; Vinod, Chathakudath P.; Nangia, Ashwini K.. The article contains the following contents:

XPS is used to understand the nature of acid-base crystalline solids, to know whether the product is a salt (proton transfer, O-···H-N+) or cocrystal (neutral adduct, O-H···N). The present study was carried out to explore if intermediate states of proton transfer from COOH to Nitrogen (the proton resides in-between hydrogen bonded to O and N, O···H···N) can be differentiated from salt and cocrystal using N 1s XPS spectroscopy. The intermediate states of proton transfer arise when the pKa difference between the acid and the conjugate base is between -1 and 4, -1 <ΔpKa< 4, a situation common with COOH and pyridine functional groups present in drug mols. and pharmaceutically acceptable coformers. Complexes of pyridine N bases with aromatic COOH mols. in nine salts/cocrystals were cocrystd. and their N 1s core binding energy in XPS spectra were measured. The proton state was analyzed by single crystal X-ray diffraction. Three new complexes were crystallized and analyzed by XPS spectra (without knowing their X-ray structures), to assess the predictive ability of XPS spectra in differentiating salt-cocrystal intermediate states against the extremities. The XPS results were subsequently confirmed by single crystal X-ray data. 1:1 and 1:2 complexes of 3,5-dinitrobenzoic acid and isonicotinamide exist as salt and salt-cocrystal continuum, resp., as shown by the N 1s core binding energy. The proton states of the crystalline solids by XPS are in good agreement with the corresponding crystal structures. Other complexes, such as those of 3,5-dinitrobenzoic acid with 1,2-di(4-pyridyl)ethylene exhibit salt-cocrystal continuum, maleic acid with 1,2-di(4-pyridyl)ethylene and acridine are salts, 2-hydroxybenzoic acid and acridine is a salt, and complex of 3,5-dinitrobenzoic acid and 3-hydroxypyridine is a salt, while fumaric acid with 1,2-di(4-pyridyl)ethylene and acridine are cocrystals. Furthermore three new acid-base complexes of 3,5-dinitrobenzoic acid with phenazine, 4-hydroxypyridine and 4-cyanopyridine were studied initially by XPS and then confirmed by X-ray diffraction. In summary, since the N 1s binding energies cluster in a narrow range as cocrystal (398.9-399.6 eV) and salt (400.9-401.9 eV), it is possible to differentiate between neutral cocrystal and ionic salt, but the salt-cocrystal continuum values in XPS spectra are not clustered in a distinct intermediate range of energy to be of predictive value. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C7H7NOIn 2021 ,《Formate-driven catalysis and mechanism of an iridium-copper complex for selective aerobic oxidation of aromatic olefins in water》 was published in Chemical Science. The article was written by Shimoyama, Yoshihiro; Kitagawa, Yasutaka; Ohgomori, Yuji; Kon, Yoshihiro; Hong, Dachao. The article contains the following contents:

A hetero-dinuclear IrIII-CuII complex with two adjacent sites was employed as a catalyst for the aerobic oxidation of aromatic olefins driven by formate in water. An IrIII-H intermediate, generated through formate dehydrogenation, was revealed to activate terminal aromatic olefins to afford an Ir-alkyl species, and the process was promoted by a hydrophobic [IrIII-H]-[substrate aromatic ring] interaction in water. The Ir-alkyl species subsequently reacted with dioxygen to yield corresponding Me ketones and was promoted by the presence of the CuII moiety under acidic conditions. The IrIII-CuII complex exhibited cooperative catalysis in the selective aerobic oxidation of olefins to corresponding Me ketones, as evidenced by no reactivities observed from the corresponding mononuclear IrIII and CuII complexes, as the individual components of the IrIII-CuII complex. The reaction mechanism afforded by the IrIII-CuII complex in the aerobic oxidation was disclosed by a combination of spectroscopic detection of reaction intermediates, kinetic anal., and theor. calculations After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 141-86-6In 2019 ,《Molecular engineering of supercapacitor electrodes with monodispersed N-doped carbon nanoporous spheres》 was published in New Journal of Chemistry. The article was written by Huang, Xinhua; Wang, Nuoya; Li, Fei; Zhu, Xingxing; Liao, Kin; Chan, Vincent; Zhang, Lidong. The article contains the following contents:

Herein, a novel polytriazine compound was designed and used as a precursor for the synthesis of high nitrogen-doped porous carbon spheres (N-doped carbon-PNSs) by direct carbonization-activation; the process was simple and based on the template-free polycondensation of 2,6-diaminopyridine and formaldehyde in an aqueous solution Moreover, by varying the 2,6-diaminopyridine to formaldehyde ratio and total monomer concentration during the synthesis of the polymeric precursor, the size of the polytriazine nanospheres could be tuned from 102 to 3900 nm with a uniform spherical geometry. After pyrolysis, the N-doped carbon-PNSs had an average N content of 8.7-10.4 wt% and surface areas of 627.8-924.4 m2 g-1; most importantly, the N-doped carbon-PNSs as high energy supercapacitor electrodes exhibited excellent cyclability and high specific capacitance, ramping up to 424 F g-1 at 1 A g-1 in 6 M KOH. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Application of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridineOn May 3, 2010 ,《Surface Catalysis of Water Oxidation by the Blue Ruthenium Dimer》 appeared in Inorganic Chemistry. The author of the article were Jurss, Jonah W.; Concepcion, Javier C.; Norris, Michael R.; Templeton, Joseph L.; Meyer, Thomas J.. The article conveys some information:

Single-electron activation of multielectron catalysis is viable in catalytic H2O oxidation with stepwise proton-coupled electron transfer, leading to high-energy catalytic precursors. For the blue dimer, cis,cis-[(bpy)2(H2O)RuIIIORuIII(H2O)(bpy)2]4+, the 1st well-defined mol. catalyst for H2O oxidation, stepwise 4e-/4H+ oxidation occurs to give the reactive precursor [(O)RuVORuV(O)]4+. This key intermediate is kinetically inaccessible at an unmodified metal oxide surface, where the only available redox pathway is electron transfer. The authors report here a remarkable surface activation of In-Sn oxide (In2O3:Sn) electrodes toward catalytic H2O oxidation by the blue dimer at electrodes derivatized by surface phosphonate binding of [Ru(4,4′-((HO)2P(O)CH2)2bpy)2(bpy)]2+. Surface binding dramatically improves the rate of surface oxidation of the blue dimer and induces H2O oxidation catalysis. The experimental process involved the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 39856-58-1On September 17, 2021 ,《Exploiting Iminoquinones as Electrophilic at Nitrogen “”N+”” Synthons for C-N Bond Construction》 was published in Organic Letters. The article was written by Mori-Quiroz, Luis M.; Comadoll, Chelsea G.; Super, Jonathan E.; Clift, Michael D.. The article contains the following contents:

New methods for C-N bond construction exploiting the N-centered electrophilic character of iminoquinones were reported. Iminoquinones, generated in situ via the condensation of o-vinylanilines with benzoquinones, underwent acid-catalyzed cyclization to afford N-arylindoles I [R = H, F; R1 = H, Me, Ph, etc.; R2 = H, Me; R3 = H, Cl, CO2Me, etc.; Ar = 3,5-di-(t-Bu)-4-OHC6H2, 3,5-di-Me-4-OHC6H2, 3,5-di-(t-Bu)-2-OHC6H2, 10-hydroxy-9-phenanthryl] in excellent yields. Under similar reaction conditions, homoallylic amines reacted analogously to afford N-arylpyrroles II [R4 = Ph, 3-MeOC6H4, 4-FC6H4, 2,6-di-FC6H3, 2,3-dihydrobenzofuran-5-yl; R5 = H, 4-MeC6H4; Ar = 3,5-di-(t-Bu)-4-OHC6H2]. Addnl., organometallic nucleophiles were shown to add to the nitrogen atom of N-alkyliminoquinones to provide amine products. Finally, iminoquinones were shown to be competent electrophiles for copper-catalyzed hydroamination. After reading the article, we found that the author used 2-Bromopyridin-3-amine(cas: 39856-58-1Product Details of 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C6H4N2O4On May 22, 2013, Kaplanek, Robert; Krchnak, Viktor published an article in Tetrahedron Letters. The article was 《Fast and effective reduction of nitroarenes by sodium dithionite under PTC conditions: application in solid-phase synthesis》. The article mentions the following:

Herein, conditions for the fast and effective reduction of aromatic nitro groups bound to hydrophobic polystyrene-based Wang and Rink resins utilizing sodium dithionite in dichloromethane-water under PTC conditions are reported. Tetrabutylammonium hydrogen sulfate (TBAHS) was found to be an effective phase-transfer catalyst for this reaction. This method allows for the reduction of nitro groups to amino groups under mild conditions with complete conversion and is tolerant of other functional groups. This method is a superior alternative to tin(II) chloride-based reduction, which is known for its shortcomings. After reading the article, we found that the author used 3-Nitroisonicotinic acid(cas: 59290-82-3Synthetic Route of C6H4N2O4)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Synthetic Route of C6H4N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2008,Synthetic Communications included an article by Dai, Liyan; Fan, Dongbo; Wang, Xiaozhong; Chen, Yingqi. Product Details of 153476-68-7. The article was titled 《Improved synthetic approach to tenatoprazole》. The information in the text is summarized as follows:

An improved synthetic approach to tenatoprazole I was described. It started from 2,3,5-trimethyl-4-nitropyridine-N-oxide with acetic anhydride via rearrangement and hydrolysis to give 2-hydroxymethyl-3,5-dimethyl-4-nitropyridine, chlorination with SOCl2 yielded 2-chloromethyl-3,5-dimethyl-4-nitropyridine hydrochloride (II), then II condensed with 2-mercapto-5-methoxyimidazole[4,5-b]pyridine to give 5-methoxy-2-[(4-nitro-3,5-dimethyl-2-pyridinyl)methylthio]imidazole[4,5-b]pyridine (III). At last the title compound I was produced by two methods: the compound III was oxidized with MCPBA and then methoxylated with CH3ONa to give I and III was first methoxylated with CH3ONa and then oxidized with MCPBA to give I. The overall yield was around 26% for both five-step syntheses. In the part of experimental materials, we found many familiar compounds, such as 2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine(cas: 153476-68-7Product Details of 153476-68-7)

2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine(cas: 153476-68-7) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 153476-68-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Martinez-Merino, Victor; Gil, Maria J.; Gonzalez, Alberto; Zabalza, Jose M.; Navarro, Javier; Manu, Maria A. published an article on February 1 ,1994. The article was titled 《New 5-substituted derivatives of ethyl 2,3-dihydro-3-oxoisothiazolo[5,4-b]pyridine-2-acetate》, and you may find the article in Heterocycles.Application of 10177-08-9 The information in the text is summarized as follows:

A new series of Et 5-substituted 2,3-dihydro-3-oxoisothiazolo[5,4-b]pyridine-2-acetate I (R = NH2, Me, Ph, H, NO2) was prepared either a) directly by reaction of 5-substituted 2-chlorothio-3-pyridinecarbonyl chlorides with Et glycine or b) by oxidation of the corresponding 2-mercapto-3-pyridinecarboxamides. Some reactions of the free acids of I as starting materials are described. The experimental process involved the reaction of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9Application of 10177-08-9)

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application of 10177-08-9 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem