Pyridine-derivatives

The author of 《Bistrifluoromethylated organocuprate [Ph4P]+[Cu(CF3)2]-: synthesis, characterization and its application for trifluoromethylation of activated heteroaryl bromides, chlorides and iodides》 were Liu, He; Shen, Qilong. And the article was published in Organic Chemistry Frontiers in 2019. Electric Literature of C8H8BrNO2 The author mentioned the following in the article:

The synthesis and characterization of a bistrifluoromethylated organocuprate [Ph4P]+[Cu(CF3)2]- and its reactions with a variety of activated heteroaryl bromides, chlorides and iodides were described. These results showed that complex [Ph4P]+[Cu(CF3)2]- can serve as a trifluoromethylating reagent. In the experiment, the researchers used many compounds, for example, Ethyl 3-bromopicolinate(cas: 434319-41-2Electric Literature of C8H8BrNO2)

Ethyl 3-bromopicolinate(cas: 434319-41-2) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Electric Literature of C8H8BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Self-assembled heterometallic complexes showing enhanced two-photon absorption and their distribution in living cells》 were Jiang, Qin; Yang, Xinda; Xiang, Pan; Dudek, Marta; Matczyszyn, Katarzyna; Samoc, Marek; Tian, Xiaohe; Zhang, Qiong; Luo, Yuhui; Wang, Daqi; Shi, Pengfei. And the article was published in New Journal of Chemistry in 2021. COA of Formula: C20H14N4 The author mentioned the following in the article:

Heterometallic binuclear Ru-Pt and trinuclear Zn-Pt complexes were prepared via self-assembly by attaching PtII-tpy (tpy = 2,2′:6′,2”-terpyridine) onto the RuII-tpy and ZnII-bis(tpy) moiety. The visible absorption bands for Ru-Pt complexes are primarily due to RuII → tpy MLCT transitions with some overlap from PtII → tpy MLCT, while no MLCT transition is observed for the Zn-Pt complex. The emission intensity of the Ru-Pt complexes was improved relative to the mononuclear RuII precursor; however, the emission of Zn-Pt was decreased when compared with strongly emissive ZnII-bis(tpy). Z-scan results revealed relatively high two-photon absorption (TPA) cross sections σ2, with maximal values of 962 GM for Ru-Pt and 200 GM for Zn-Pt. All the heterometallic complexes localize preferably into lysosomes by confocal fluorescence imaging results, which also showed improved cell-free 1O2 quantum yield compared to their mononuclear precursor. The experimental process involved the reaction of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3COA of Formula: C20H14N4)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. COA of Formula: C20H14N4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Terpyridine-functionalized chemically cross-linked polyacrylamide hydrogel for white emission and multistimuli-responsive behaviour》 were Fan, Kaiqi; Wang, Xiaobo; Ma, Yongpeng; Yang, Haoran; Han, Guanglu; Zhou, Liming; Fang, Shaoming. And the article was published in New Journal of Chemistry in 2020. COA of Formula: C20H14N4 The author mentioned the following in the article:

A highly efficient and multifunctional white-emitting hydrogel was fabricated using a facile copolymerization process by introducing a hydrophilic terpyridine-based chromophore into a polyacrylamide network. White emission was obtained by a simple procedure for adjusting the concentration of the chromophore. The CIE 1931 chromaticity coordinates of white emission with 360 nm excitation were (0.349, 0.331). Exploiting the specific sensitivities of the terpyridyl group, the white emission was also highly sensitive to pH and metal ions. We envision this photoluminescent hydrogel as a versatile material for chem. and environmental sensing. In the experiment, the researchers used 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3COA of Formula: C20H14N4)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. COA of Formula: C20H14N4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2010,Zheng, Xiaowan; Pan, Yongmei; Acharya, Chayan; Swaan, Peter W.; Polli, James E. published 《Structural Requirements of the ASBT by 3D-QSAR Analysis Using Aminopyridine Conjugates of Chenodeoxycholic Acid》.Bioconjugate Chemistry published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

The human apical sodium-dependent bile acid transporter (ASBT) is a validated drug target and can be employed to increase oral bioavailability of various drug conjugates. The aim of the present study was to investigate the chem. space around the 24-position of bile acids that influences both inhibition and uptake by the transporter. A series of 27 aminopyridine and aminophenol conjugates of glutamyl-chenodeoxycholate were synthesized and their ASBT inhibition and transport kinetics (parametrized as Ki, Kt, and Jmax) measured using stably transfected ASBT-MDCK cells. All conjugates were potent ASBT inhibitors. Monoanionic conjugates exhibited higher inhibition potency than neutral conjugates. However, neutral conjugates and chloro-substituted monoanionic conjugates were not substrates, or at least not apparent substrates. Kinetic anal. of substrates indicated that similar values for Ki and Kt implicate substrate binding to ASBT as the rate-limiting step. Using 3D-QSAR, four inhibition models and one transport efficiency model were developed. Steric fields dominated in CoMFA models, whereas hydrophobic fields dominated CoMSIA models. The inhibition models showed that a hydrophobic or bulky substitute on the 2 or 6 position of a 3-aminopyridine ring enhanced activity, while a hydrophobic group on the 5 position was detrimental. Overall, steric and hydrophobic features around the 24 position of the sterol nucleus strongly influenced bile acid conjugate interaction with ASBT. The relative location of the pyridine nitrogen and substituent groups also modulated binding. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9Category: pyridine-derivatives) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Devi, Namita; Hazarika, Sukanya; Gogoi, Prasanta; Barman, Pranjit published 《A novel dual-nano assisted synthesis of symmetrical disulfides from aryl/alkyl halides》.Synthetic Communications published the findings.Safety of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

A novel approach towards dual-nano assisted synthesis of disulfides from coupling of alkyl/aryl halides and sulfur nanoparticles has been reported. The indium oxide nanoparticles as catalyst expedite the conversion and sulfur nanoparticles notably enhances the miscibility, providing a faster, high yielding and cost-effective process in an ethanol-water system. The method has synthetic advantages in terms of mild reaction framework, catalyst regeneration, and absence of any sulfide or polysulfide linkage as byproduct leading to a column free synthesis. A variety of alkyl, aryl and heteroaryl sym. disulfides are obtained in good to excellent yields up to 98%.5-Bromo-2-chloropyridine(cas: 53939-30-3Safety of 5-Bromo-2-chloropyridine) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Inorganica Chimica Acta included an article by Chen, Dong-Mei; Wu, Xiao-Fan; Liu, Yong-Jie; Huang, Chao; Zhu, Bi-Xue. Computed Properties of C7H7NO. The article was titled 《Synthesis, crystal structures and vapor adsorption properties of Hg(II) and Cd(II) coordination polymers derived from two hydrazone Schiff base ligands》. The information in the text is summarized as follows:

Four coordination polymers, [HgL1Br2]n (1), {[Cd(L1)2Cl2]·2CH3OH}n (2), [HgL2Cl2]n (3) and [Cd(L2)2Cl2]n (4), were synthesized and characterized from two hydrazone Schiff base ligands (L1 and L2) with mercury(II) or cadmium(II) halide, resp. In complexes 1 and 3, each mercury(II) center is five-coordinated with distorted square pyramidal geometry in 1-dimensional coordination polymers. In complexes 2 and 4, each cadmium(II) center is six-coordinated with slightly distorted octahedral geometry in 1-dimensional looped-chain structures. The ligands show different coordination sites in the formation of coordination polymers. In complexes 2, 3 and 4, the ligands coordinate to the metal centers by pyridine nitrogen atoms and amino nitrogen atoms, whereas in complex 1 it coordinates by pyridine nitrogen atoms and carbonyl oxygen atoms instead of amino nitrogen atoms. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Copper-catalyzed versatile C(sp3)-H arylation: synthetic scope and regioselectivity investigations》 were Zhou, Jiadi; Zou, Yawen; Zhou, Peng; Chen, Zhiwei; Li, Jianjun. And the article was published in Organic Chemistry Frontiers in 2019. Synthetic Route of C6H4N2 The author mentioned the following in the article:

The copper-catalyzed versatile C(sp2)-C(sp3) bond formation with N-heteroaromatics and hydrogen donors was developed. Various alkanes and ethers reacted with quinolines, isoquinolins, pyridines, benzooxazole and benzothiazole to gave the corresponding C(sp2)-H alkylation products via cross-dehydrogenative coupling. The high regioselective C(sp2)-halogen alkylation of (hetero)aryl chlorides and (hetero)aryl bromides with ethers via elimination of the halogen radical. The reaction mechanism was investigated with control experiments The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Synthetic Route of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Synthetic Route of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A near infrared light emitting electrochemical cell with a 2.3 V turn-on voltage》 were Nemati Bideh, Babak; Shahroosvand, Hashem; Sousaraei, Ahmad; Cabanillas-Gonzalez, Juan. And the article was published in Scientific Reports in 2019. COA of Formula: C12H12N2 The author mentioned the following in the article:

We report on an organic electroluminescent device with simplified geometry and emission in the red to near IR (NIR) spectral region which, has the lowest turn-on voltage value, 2.3 V, among light emitting electrochem. cells (LEECs). We have synthesized and characterized three novel ruthenium π-extended phenanthroimidazoles which differ on their NN̂ ligands. The use of di-Me electron donating groups along with the π-extended phenanthroimidazole moiety promotes ambipolar transport thereby avoiding the use of addnl. charge transport layers. Furthermore, a facile cathode deposition method based on transfer of a molten alloy (Ga:In) on top of the active layer is deployed, thus avoiding high vacuum thermal deposition which adds versatile assets to our approach. We combine ambipolar charge transport organic complex design and a simple ambient cathode deposition to achieve a potentially cost effective red to NIR emitting device with outstanding performance, opening new avenues towards the development of simplified light emitting sources through device optimization. The results came from multiple reactions, including the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6COA of Formula: C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.COA of Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Facile one-pot protocol of derivatization nitropyridines: access to 3-acetamidopyridin-2-yl 4-methylbenzenesulfonate derivatives》 were Lin, Ling; Chen, Xiaoguang; Zhao, Junhao; Lin, Suitao; Ma, Guojian; Liao, Xiaojian; Feng, Pengju. And the article was published in Heterocyclic Communications in 2019. Application In Synthesis of 6-Bromopyridin-3-amine The author mentioned the following in the article:

An efficient one-pot protocol for conversion of easily accessible 3-nitropyridines to 3-acetamidopyridin-2-yl 4-methylbenzenesulfonate derivatives which were core structures of many pharmaceutical mols was reported. The strategy successfully combined a three-step reaction in one-pot via progressively adding different reactants at rt. The reaction displayed good functional group tolerance and regioselectivity. Structurally diversified 3-nitropyridine was time-efficiently (3.5 h) derivatized to various functional 2-O,3-N-pyridines which were apt for further elaborations. The transformation was amenable to gram-scale synthesis. After reading the article, we found that the author used 6-Bromopyridin-3-amine(cas: 13534-97-9Application In Synthesis of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Application In Synthesis of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria》 were Chen, Peng; Zhang, Yinyong; Shi, Chenghui; Meng, Xin; Yang, Yushe; Zhou, Xianli; Guo, Bin. And the article was published in Journal of Chemical Research in 2019. Recommanded Product: 2,5-Dibromopyridine The author mentioned the following in the article:

An improved process for the synthesis of potent oxazolidinone candidate I against multi-drug resistant bacteria was developed. Compared with the original synthetic route, this new approach was two steps shorter, and all of the steps involved simple purifications without column chromatog. More importantly, it avoided the use of explosive azide compounds and expensive metal catalysts. The new reaction conditions were mild and safe, which was more suitable for the scalable synthesis of YG-056SP for preclin. studies. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Recommanded Product: 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Recommanded Product: 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem