Pyridine-derivatives

The author of 《Push-pull isomers of indolizino[6,5,4,3-def]phenanthridine decorated with a triarylboron moiety》 were Dong, Lei; Saraci, Felix; Yuan, Kang; Wang, Xiang; Wang, Suning. And the article was published in Organic & Biomolecular Chemistry in 2019. Computed Properties of C6H6BrN The author mentioned the following in the article:

1,3-Dipolar cycloaddition reactions between a new azomethine ylide and three BPhMes2-functionalized internal alkynes produced three pairs of fluorescent push-pull regioisomers I and II (R = 2,4,6-Me3C6H2; 1a-3a, 1b-3b, resp., Ar = C6F5, 5-trifluoromethyl-2-pyridyl, 5-methyl-2-pyridyl), which show distinct electronic and photophys. properties. All the six compounds are found to exhibit charge-transfer (CT) fluorescence, and some of which show rare and interesting temperature “”turn-on”” fluorescence. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Computed Properties of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Computed Properties of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Realization of Highly Efficient Red Phosphorescence from Bis-Tridentate Iridium(III) Phosphors》 were Gnanasekaran, Premkumar; Yuan, Yi; Lee, Chun-Sing; Zhou, Xiuwen; Jen, Alex K.-Y.; Chi, Yun. And the article was published in Inorganic Chemistry in 2019. Formula: C5H3Br2N The author mentioned the following in the article:

Bis-tridentate Ir(III) metal complexes bring forth interesting photophys. properties, among which the orthogonal arranged, planar tridentate chelates could increase the emission efficiency due to the greater rigidity and, in the meantime, allow strong interligand stacking that could deteriorate the emission efficiency. The authors bypassed this hurdle by design of 5 bis-tridentate Ir(III) complexes (1-5), to which both of their monoanionic ancillary and dianionic chromophoric chelate were functionalized derivative of 2-pyrazolyl-6-phenylpyridine, i.e. pzpyphH2 parent chelate. Hence, addition of Ph substituent to the pyrazolyl fragment of pzpyphH2 gave rise to the precursors of monoanionic chelate (A1H-A3H), on which the addnl. CMe3 and/or methoxy groups were introduced at the selected positions for tuning their steric and electronic properties, while precursors of dianionic chelates was judiciously prepared with an isoquniolinyl central unit on pziqphH2 in giving the red shifted emission (cf. L1H2 and L2H2). Factors affected their photophys. properties were discussed by theor. methods based on DFT and TD-DFT calculation, confirming that the T1 excited state of all studied Ir(III) complexes shows a mixed metal-to-ligand charge transfer (MLCT), intraligand charge transfer (ILCT), ligand-to-ligand charge transfer (LLCT), and ligand-centered (LC) transition character. But the poor quantum yield of 3 is due to the facilitation of the nonradiative decay in comparison to the radiative process. As for potential OLED applications, Ir(III) complex 2 gives superior performance with maximum efficiencies of 28.17%, 41.25 cd A-1 and 37.03 lm W-1, CIEx,y = 0.63, 0.37 at 50 mA cm-2, and small efficiency roll-off. Crystallog. data are given. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dibromopyridine(cas: 626-05-1Formula: C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis and structure of lithium 3-trifluoromethyl-1,3-diketonates containing pyridyl substituents》 were Slepukhin, P. A.; Boltacheva, N. S.; Filyakova, V. I.; Charushin, V. N.. And the article was published in Russian Chemical Bulletin in 2019. HPLC of Formula: 1122-54-9 The author mentioned the following in the article:

Lithium 3-trifluoromethyl-1,3-diketonates containing pyridyl substituents were synthesized. The specific features of the crystal structures of Li (Z)-1,1,1-trifluoro-4-oxo-4-(pyridin-3-yl)- and (Z)-1,1,1-trifluoro-4-oxo-4-(pyridin-4-yl)but-2-en-2-olates were revealed by x-ray diffraction. These compounds have a polymeric structure with Li cations in different coordination modes. The 1,3-diketonate group is involved in chelation and formation of O bridges, thereby linking two types of Li atoms. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Study of energy transfer mechanism in the EuIII and GdIII homobimetallic complexes containing the anti-inflammatory drug naproxen and N,N-donors ligands》 were Gomes, Emmanuel M.; Franco, Douglas F.; Scarpari, Sergio L.; Colaco, Marcos V.; Ferreira, Monica S.; Freire, Ricardo O.; Marques, Lippy F.. And the article was published in Journal of Luminescence in 2019. Application of 1134-35-6 The author mentioned the following in the article:

In this work, we present the synthesis, solid state characterization and complete photoluminescence study of new important homobimetallic lanthanide complexes containing the non-steroidal anti-inflammatory drug (NSAID) naproxen. The anal. and spectroscopic techniques reveals the formation of eight compounds of general formula [Ln2(nap)6(H2O)4] (Eu 1 and Gd 2), [Ln2(nap)6(bpy)2] (Eu 3 and Gd 4), [Ln2(nap)6(4,4′-dmbpy)2] (Eu 5 and Gd 6) and [Ln2(nap)6(phen)2] (Eu 7 and Gd 8), where: nap = naproxen ligand, bpy =2,2′-bipyridine, 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridine and phen = 1,10-phenanthroline. Using the RM1 model, the mol. structures of the EuIII complexes were calculated, with your optimized ground state geometries used to obtain all details involved in the energy transfer process. From the resp. GdIII complexes were obtained the lowest ligand triplet states, proving that the photoluminescence in the EuIII naproxen complexes is proposed to be a ligand sensitized luminescence process. On the other hand, the position of the triplet states also explains the non-effective energy transfer in the TbIII naproxen complexes. The presence of N,N-donors ligands (bpy, 4,4′-dmbpy and phen) results in an 3-4-fold increase in the quantum efficiency when compared with the EuIII complex without nitrogen ligands. The high values of emission quantum efficiency (η ∼ 70 – 98%) show the EuIII complexes can be potential candidates as emitters in biol. assays. After reading the article, we found that the author used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Application of 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Application of 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Study of zero-field splitting in Ni(II) complexes with near octahedral geometry》 were Lomjansky, Dominik; Rajnak, Cyril; Titis, Jan; Moncol, Jan; Boca, Roman. And the article was published in Inorganica Chimica Acta in 2019. HPLC of Formula: 1134-35-6 The author mentioned the following in the article:

Four novel Ni(II) complexes, [Ni(dppmO,O)2(NCS)2] (1), [Ni(dppmO,O)3][NiCl4] (2), [Ni(dmbpy)(H2O)2Br2] (3) and [Ni(dppmO,O)3][NiCl4]·[Ni(dppm)Cl2] (4) (dppm = bis(diphenylphosphino)methane, dppmO,O = bis(diphenylphosphanoxido)methane, dmbpy = 4,4′-dimethyl-2,2′-bipyridine), were synthesized and structurally and magnetically characterized. 1 And 3 are pseudooctahedral, while 2 and 4 are unique due to the existence of hexa- or tetracoordination in two/three independent Ni(II) atoms. For hexacoordinated systems the magnetic data confirm small magnetic anisotropy expressed through the axial zero-field splitting parameter D/hc = -4.5 to +4.4 cm-1. For [NiCl4]2- tetrahedral units (in complexes 2 and 4) the magnetic anisotropy is substantially larger. Exptl. findings were confirmed by ab initio calculations and forwarded to magnetostructural D-correlations. In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6HPLC of Formula: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.HPLC of Formula: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A nickel pyridine-selenolate complex for the photocatalytic evolution of hydrogen from aqueous solutions》 were Xie, An; Tao, Yun-Wen; Peng, Cheng; Luo, Geng-Geng. And the article was published in Inorganic Chemistry Communications in 2019. Quality Control of 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

A nickel pyridine-selenolate complex, [Ni(4,4′-dmbpy)(2-pySe)2] (1, where 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridine, and 2-pySe = pyridine-2-selenolate), was synthesized, and studied for photocatalytic production of H2 from aqueous solution Electrochem. studies show that the nickel complex 1 can efficiently electrocatalyze H2 evolution from weakly acidic solutions Under visible-light irradiation (λ > 420 nm), the complex 1 displays impressive H2 evolution activity with a TON of 1340 (based on a catalyst) in a noble-metal-free system, which contains fluorescein (Fl) as photosensitizer and triethylamine (TEA) as sacrificial electron donor in acetonitrile-water solution It should be noted that complex 1 is the rare example of nickel pyridine-selenolate complex as mol. photocatalyst for water reduction After reading the article, we found that the author used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Quality Control of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Quality Control of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Safety and Efficacy of NC120 for Improving Lipid Profile: A Double Blind Randomized Controlled Trial.》 were Nafrialdi, Nafrialdi; Hudyono, Johannes; Suyatna, Frans D; Setiawati, Arini. And the article was published in Acta medica Indonesiana in 2019. Recommanded Product: Picolinic acid The author mentioned the following in the article:

BACKGROUND: the use of statin to lower blood cholesterol is often associated with bothersome adverse effects such as myopathy and liver dysfunction. NC120 is herbal lipid lowering drug containing red yeast rice (RYR) extract, guggulipid, and chromium picolinate, and expected to have better safety profile. The aim of this study was to evaluate the efficacy and safety profiles of NC120 in lowering blood lipid. METHODS: this was a double blind randomized clinical trial comparing NC120 with placebo in subjects with hypercholesterolemia. Two capsules of NC120 or placebo were administered twice a day for 28 days. Blood total-cholesterol, LDL-cholesterol, and triglyceride were measured on day-0, day-7, and day-28. Unpaired t-test was used to compare study parameter between groups, and one-way ANOVA was used to compare within group. RESULTS: 25 subjects received NC120 and 24 subjects received placebo. Significant decrease of total cholesterol and LDL-cholesterol were observed since day-7 in NC120 group, while the changes in placebo group were not significant at all time of observation. No significant decrease of triglyceride was observed in NC120 group and in placebo group. Side effects were minor and comparable between the two groups. CONCLUSION: NC120 is effective in reducing total cholesterol and LDL-cholesterol, but not triglyceride. This drug shows a good safety profile, and thus can be considered for patients who can not tolerate statin drugs. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Perrhenate-ions adsorption by N-substituted chitosan derivatives》 were Melchakova, O. V.; Pestov, A. V.; Pechishcheva, N. V.; Shunyaev, K. Yu.. And the article was published in Russian Chemical Bulletin in 2019. SDS of cas: 103-74-2 The author mentioned the following in the article:

A comparative study of the sorption properties of N-(2-carboxyethyl)chitosan (CEC), N-(2-sulfoethyl)chitosan (SEC), N-(2,3-dihydroxy)propyl chitosan (HPC) and N-2-(2-pyridyl)ethyl chitosan (PEC) with respect to perrhenate ions in an acidic medium was carried out. From the anal. of the adsorption isotherms and the perrhenate ion adsorption degrees as functions of pH, the efficiency of adsorbents decreases in the sequence PEC > SEC > HPC > CEC. The studied chitosan derivatives are characterized by a higher rate of sorption of perrhenate ions in comparison with known com. anionites. In the case of PEC, accompanying ions have the least effect on the sorption. After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2SDS of cas: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. SDS of cas: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Cs2CO3 Catalyzed Intramolecular Aminocarbonylation of Alkynes: Synthesis of 3-Amino-1H-inden-1-ones from N-tert-Butyl-2-(1-alkynyl)benzaldimines》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Guo, Zhen; Liu, Tao; Liang, Xiujuan; Wu, Yuting; Yao, Tuanli. Recommanded Product: 2-Bromonicotinaldehyde The article mentions the following:

Synthesis of a wide variety of 3-amino-1H-inden-1-ones I [R1 = H, 5-F, 6-Cl, etc.; R2 = Ph, 2-MeC6H4, 4-CO2EtC6H4, etc.] from N-tert-butyl-2-(1-alkynyl)benzaldimines via intramol. aminocarbonylation of alkynes using Cs2CO3 as catalyst and air as oxidant was developed. This highly atom-efficient, transition-metal-free reaction proceeded under thermal conditions. The reaction proceeded through an unprecedented 5-exo-dig cyclization of N-tert-butyl-2-(1-alkynyl)benzaldimines and thermal rearrangement of 3-methylene-2λ2-isoindolin-1-ols was proposed.2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification》 was published in Nucleic Acids Research in 2020. These research results belong to Thomas, Sherine E.; Whitehouse, Andrew J.; Brown, Karen; Burbaud, Sophie; Belardinelli, Juan M.; Sangen, Jasper; Lahiri, Ramanuj; Libardo, Mark Daben J.; Gupta, Pooja; Malhotra, Sony; Boshoff, Helena I. M.; Jackson, Mary; Abell, Chris; Coyne, Anthony G.; Blundell, Tom L.; Floto, Rodrigo Andres; Mendes, Vitor. Formula: C6H7Br2N The article mentions the following:

Translational frameshift errors are often deleterious to the synthesis of functional proteins and could therefore be promoted therapeutically to kill bacteria. TrmD (tRNA-(N(1)G37) methyltransferase) is an essential tRNA modification enzyme in bacteria that prevents +1 errors in the reading frame during protein translation and represents an attractive potential target for the development of new antibiotics. Here, we describe the application of a structure-guided fragment-based drug discovery approach to the design of a new class of inhibitors against TrmD in Mycobacterium abscessus. Fragment library screening, followed by structure-guided chem. elaboration of hits, led to the rapid development of drug-like mols. with potent in vitro TrmD inhibitory activity. Several of these compounds exhibit activity against planktonic M. abscessus and M. tuberculosis as well as against intracellular M. abscessus and M. leprae, indicating their potential as the basis for a novel class of broad-spectrum mycobacterial drugs. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Formula: C6H7Br2N) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem