Pyridine-derivatives

The author of 《Smart Responsive Luminescent Aptamer-Functionalized Covalent Organic Framework Hydrogel for High-Resolution Visualization and Security Protection of Latent Fingerprints》 were Hai, Jun; Wang, Hao; Sun, Panpan; Li, Tianrong; Lu, Siyu; Zhao, Yang; Wang, Baodui. And the article was published in ACS Applied Materials & Interfaces in 2019. Synthetic Route of C12H13N3 The author mentioned the following in the article:

Covalent organic frameworks (COFs) have been proposed as alternative candidates for “”smart”” materials due to its ordered π-columnar structures. However, it remains a challenge to develop external-stimuli-responsive luminescent COFs for confidential information protection. Here we have designed and synthesized a water-dispersible and smart responsive luminescent CM-cellulose (CMC)-COF-LZU1 hydrogel with encapsulated 5-(Dimethylamino)-N,N-bis (pyridin-2-ylmethyl) naphthalene-1-sulfonamide (DPYNS), named CMC-COF-LZU1⊃DPYNS, for LFP imaging and encryption. We show that the fluorescence of CMC-COF-LZU1⊃DPYNS is reversibly switchable upon addition of Cu2+/H2O. This effect endows potential applications of tunable luminescent COFs based hydrogel as an invisible security probe for imaging, record, storage, and security of latent fingerprint information. It is shown that the latent fingerprint information incubated by the CMC-COF-LZU1⊃DPYNS hydrogel is invisible in the presence of Cu2+, but three levels of fingerprint features with high-resolution patterns can be readable upon addition of H2O under UV light. The design strategy provides a promising platform for the development of smart responsive luminescent COFs and their detection and protection of valuable LFP information. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Synthetic Route of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Synthetic Route of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《MIL-101 supported highly active single-site metal catalysts for tricomponent coupling》 were Sun, Weng-Jie; Gao, En-Qing. And the article was published in Applied Catalysis, A: General in 2019. Application In Synthesis of 4-Ethynylpyridine The author mentioned the following in the article:

Metal-organic frameworks with regular pore structures provide powerful platforms for the design of single-site metal catalysts for chem. transformation. In this paper, we develop a facile, stable and recyclable MOF-supported Cu(II) catalyst, MIL-101-SO3Cu. It shows extremely high activity for the A3 coupling of alkynes, aldehydes and amines. The turnover frequency can reach 6.8 × 105 h-1 under neat conditions, which is the highest so far reported for the reaction. The high activity is because the specific structure of the MIL-101-SO3 support enables a single-site dispersion and an unhindered open environment for the metal ion. MIL-101-SO3Cu also exhibits high activity for the one-pot cascade reactions combining A3 coupling and 5-endo-dig cyclization. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Application In Synthesis of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application In Synthesis of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors》 were Huang, Yi-You; Yu, Yan-Fa; Zhang, Chen; Chen, Yiping; Zhou, Qian; Li, Zhuoming; Zhou, Sihang; Li, Zhe; Guo, Lei; Wu, Deyan; Wu, Yinuo; Luo, Hai-Bin. And the article was published in Journal of Medicinal Chemistry in 2019. Recommanded Product: 103-74-2 The author mentioned the following in the article:

Pulmonary arterial hypertension (PAH) causes pathol. increase in pulmonary vascular resistance, leading to right-heart failure and eventual death. Previously, phosphodiesterase-10 (PDE10) was reported to be a promising target for PAH based on the studies with a nonselective PDE inhibitor papaverine, but little progress has been made to confirm the practical application of PDE10 inhibitors. To validate whether PAH is ameliorated by PDE10 inhibition rather than other PDE isoforms, here we report an integrated strategy to discover highly selective PDE10 inhibitors as chem. probes. Structural optimization resulted in a PDE10 inhibitor 2b with subnanomolar affinity and good selectivity of >45 000-fold against other PDEs. The cocrystal structure of the PDE10-2b complex revealed an important H-bond interaction between 2b and Tyr693. Finally, compound 2b significantly decreased the arterial pressure in PAH rats and thus validated the potential of PDE10 as a novel anti-PAH target. These findings suggest that PDE10 inhibition may be a viable treatment option for PAH. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heterocycles 45.Synthesis, characterization and biological evaluation of 3-indolyl-1-pyridyl-2-propenones as anticancer agents》 was published in Farmacia (Bucharest, Romania) in 2020. These research results belong to Kamga, Justin; Leonte, Denisa; Ambassa, Pantaleon; Mbaveng, Armelle T.; Fotso, Ghislain W.; Coman, Fana-Maria; Ngadjui, Bonaventure T.; Kuete, Victor; Zaharia, Valentin; Ngameni, Bathelemy. Category: pyridine-derivatives The article mentions the following:

A series of seven indolyl pyridyl propenones I [R = H, Me, Et, etc.; Ar = 3-pyridyl, 4-pyridyl] were synthesized via Claisen-Schmidt condensation with 68.8-91.8% yields. All the synthesized compounds I were purified and characterized by m.ps., IR, 1H NMR, 13C NMR and HRMS. The cytotoxicity of the synthesized indolyl pyridyl propenones I and doxorubicin, used as pos. control, was determined in a panel of nine human cancer cell lines including both sensitive and drug-resistant phenotypes, as well as in normal AML12 hepatocytes. Compounds I [R = Et, allyl; Ar = 4-pyridyl] and [R = Me; Ar = 3-pyridyl] displayed half maximal inhibitory concentration (IC50) values below 100μM in all tested cancer cell lines meanwhile, other compounds displayed selective activities. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A novel 1-D chain organic-inorganic hybrid CuII-PrIII heterometallic germanomolybdate decorated by 2-picolinic acid ligands》 was published in Inorganic Chemistry Communications in 2020. These research results belong to Hu, Huifen; Cui, Limin; Liu, Mengling; Yang, Gengxu; Chen, Lijuan. Name: Picolinic acid The article mentions the following:

A novel 1-dimensional chain organic-inorganic hybrid CuII-PrIII heterometallic germanomolybdate decorated by 2-picolinic acid ligands [NH4]2[Pr(H2O)5]2[Cu(pic)2]2[Cu(pic)2(H2O)2]3[α- GeMo12O40]2·24H2O (1) [Hpic = 2-picolinic acid] was obtained via the strategy of combining in-situ assembly reaction and stepwise synthesis in aqueous solution and structurally characterized by IR spectra, elemental analyses, single-crystal x-ray diffraction, and TGA. It should be pointed out that the polyoxoanion unit of 1 consists of two plenary Keggin [α-GeMo12O40]4- anion and an organic-inorganic hybrid 3d-4f heterometallic {[Pr(H2O)5]2[Cu(pic)2]2[Cu(pic)2(H2O)2]3}6+ segment and neighboring polyoxoanion units are further expanded into a 1-dimensional chain alignment by virtue of {Cu(pic)2} linkers. Also, the absorption properties of 1 toward the cationic dye methylene blue (MB) in water solution were studied in detail, which shows a good absorption capacity toward the dye in aqueous solution and the absorption kinetic conforms to the 2nd-order kinetic model. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Name: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Name: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《2,5-Dihydroxyterephthalic Acid Accelerated Cu(NO3)2.3H2O-Catalyzed Homocoupling Reaction of Arylboronic Acids》 was published in Letters in Organic Chemistry in 2020. These research results belong to Wu, Fengtian; Nan, Chenlong; Xie, Jianwei; Ma, Mingyang. Category: pyridine-derivatives The article mentions the following:

A catalyst system derived from com. available Cu(NO3)2.3H2O and 2,5-dihydroxyterephthalic acid is applied to the homocoupling reaction of arylboronic acids. This transformation provides a convenient approach to sym. biaryls with good to excellent yields (39%- 95%), and exhibits good functional group compatibility. Furthermore, biaryl can be prepared in gram quantities in good yield. In the experimental materials used by the author, we found 2-Pyridinylboronic acid(cas: 197958-29-5Category: pyridine-derivatives)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Intermolecular Iodofluoroalkylation of Unactivated Alkynes and Alkenes Mediated by Manganese Catalysts》 was written by Ji, Yun-Xing; Wang, Lu-Jun; Guo, Wei-Si; Bi, Qirui; Zhang, Bo. Recommanded Product: 2510-22-7 And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

An approach for iodofluoroalkylation of unactivated alkynes and alkenes facilitated by an earth-abundant and inexpensive manganese catalyst, Mn2(CO)10, is reported. This protocol employs visible light as the energy input and shows a wide substrate scope and high functional-group compatibility. A variety of synthetically useful fluoroalkylated alkyl and alkenyl iodides can be prepared in moderate to excellent yields. The reaction features high efficiency, operational simplicity, scalability, as well as excellent chemo-, regio-, and E/Z selectivities.4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 2510-22-7) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A lysosome-targeted ruthenium(II) polypyridyl complex as photodynamic anticancer agent》 was written by Chen, Jun; Tao, Qin; Wu, Jian; Wang, Mengmeng; Su, Zhi; Qian, Yong; Yu, Tao; Wang, Yan; Xue, Xuling; Liu, Hong-Ke. SDS of cas: 1134-35-6 And the article was included in Journal of Inorganic Biochemistry in 2020. The article conveys some information:

Polypyridyl ruthenium complexes as novel photosensitizers had drawn attention due to its high selectivity towards cancer cells and low toxicity to normal cells. Herein, we synthesized a lysosome-targeted polypyridyl ruthenium complex Rhein-Ru(bpy)3 (bpy = 2,2′-bipyridine, rhein = 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid), tethering with the Chinese medicine herb rhein. Rhein-Ru(bpy)3 exhibited high phototoxicity with short time of irradiation against tumor cell lines with the IC50 value of 2.4- 8.7 μM, and higher cytotoxicity against cisplatin-resistant A2780 cell lines, suggesting that Rhein-Ru(bpy)3 could overcome the cisplatin resistance. Moreover, Rhein-Ru(bpy)3 displayed low cytotoxicity towards cell lines in dark incubation, which was beneficial to reduce the toxic side effects towards normal cell lines. Besides, the confocal imaging and western blotting assay results suggested that Rhein-Ru(bpy)3 could induce cancer cell death through the autophagy pathway. These results inspired us that lysosome-targeted photosensitizers based on ruthenium complexes showed great potential for photodynamic therapy (PDT) application in cancer treatment. In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6SDS of cas: 1134-35-6) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.SDS of cas: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Proton-Coupled Electron Transfer for Photoinduced Generation of Two-Electron Reduced Species of Quinone》 was written by Dey, Ananta; Ghorai, Nandan; Das, Amitava; Ghosh, Hirendra N.. Computed Properties of C12H12N2 And the article was included in Journal of Physical Chemistry B in 2020. The article conveys some information:

Purpose-built mols. that follow the fundamental process of photosynthesis have significance in developing better insight into the natural photosynthesis process. Quinones have a significant role as electron acceptors in natural photosynthesis, and their reduction is assisted through H-bond donation or protonation. The major challenge in such studies is to couple the multielectron and proton-transfer process and to achieve a reasonably stable charge-separated state for the elucidation of the mechanistic pathway. We have tried to address this issue through the design of a donor-acceptor-donor mol. triad (2RuAQ) derived from two equivalent [Ru(bpy)3]2+ derivatives and a bridging anthraquinone moiety (AQ). Photoinduced proton-coupled electron transfer (PCET) for this mol. triad was systematically investigated in the absence and presence of hexafluoroisopropanol and p-toluenesulfonic acid (PTSA) using time-resolved absorption spectroscopy in the ultrafast time domain. Results reveal the generation of a relatively long-lived charge-separated state in this multi-electron transfer reaction, and we could confirm the generation of AQ2- and RuIII as the transient intermediates. We could rationalize the mechanistic pathway and the dynamics associated with photoinduced processes and the role of H-bonding in stabilizing charge-separated states. Transient absorption spectroscopic studies reveal that the rates of intramol. electron transfer and the mechanistic pathways associated with the PCET process are significantly different in different solvent compositions having different polarities. In acetonitrile, a concerted PCET mechanism prevails, whereas the stepwise PCET reaction process is observed in the presence of PTSA. The results of the present study represent a unique model for the mechanistic diversity of PCET reactions.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Computed Properties of C12H12N2) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Computed Properties of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Growth and characterization of picolinium maleate (PM) crystals》 was written by Senthil Kannan, K.; Venkatachalam, K.; Bhakya, K.; Sharmidha, B.; Kalaivani, M.; Devi, S. Gayathri. Recommanded Product: Picolinic acid And the article was included in AIP Conference Proceedings in 2020. The article conveys some information:

Picolinium Maleate crystals are of NLO type and are having extensive range of employing in opto-electronic and frequency doubling and which have Empirical formula as C10H9NO6, these crystal belongs to monoclinic system, with space group as P21/c and at. grid scaling are a=14.650Å, b=10.398Å, c=6.908Å, α=γ=90°, β=100° and crystallite size is 0.25*0.16*0.25 mm3. As the crystals of PM are of NLO of the second order, it can be used for bio applications and here used for anti-diabetic (AD) activities and filter usefulness exptl. (c) 2020 American Institute of Physics. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem