Pyridine-derivatives

《Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Huang, Yadan; Wu, Xu-Nian; Zhou, Qian; Wu, Yinuo; Zheng, Dongxiao; Li, Zhe; Guo, Lei; Luo, Hai-Bin. Formula: C6H7Br2N The article mentions the following:

To validate the hypothesis that Tyr748 is a crucial residue to aid the discovery of highly selective phosphodiesterase 8A (PDE8A) inhibitors, we identified a series of 2-chloroadenine derivatives based on the hit clofarabine. Structure-based design targeting Tyr748 in PDE8 resulted in the lead compound 3a (I) (IC50 = 0.010 μM) with high selectivity with a reasonable druglike profile. In the X-ray crystal structure, I bound to PDE8A with a different mode from 3-isobutyl-1-methylxanthine (a pan-PDE inhibitor) and gave a H-bond of 2.7 Å with Tyr748, which possibly interprets the 220-fold selectivity of 3a against PDE2A. Addnl., oral administration of compound I achieved remarkable therapeutic effects against vascular dementia (VaD), indicating that PDE8 inhibitors could serve as potential anti-VaD agents. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Formula: C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Catalyst-free and solvent-free hydroboration of alkynes》 was written by Jaladi, Ashok Kumar; Choi, Hyeon Seong; An, Duk Keun. Name: 4-Ethynylpyridine And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

The hydroboration of alkynes with pinacolborane (HBpin) under catalyst- and solvent-free conditions was demonstrated. Various alkynes were smoothly converted into alkenyl boronate esters in good to excellent yields at 110°C. The gram-scale hydroboration of alkynes provided the corresponding boronates, which were further utilized for various chem. transformations and coupling reactions. In the experimental materials used by the author, we found 4-Ethynylpyridine(cas: 2510-22-7Name: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Ring-Opened Hemiporphyrazines: Helical Molecules Exhibiting Circularly Polarized Luminescence》 was written by Tanaka, Yusuke; Murayama, Tomotaka; Muranaka, Atsuya; Imai, Eiyu; Uchiyama, Masanobu. Reference of 2,6-Diaminopyridine And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

Authors designed and synthesized a new type of small helical mol. exhibiting intense circularly polarized luminescence (CPL) (12H) by modifying a 20π-electron hemiporphyrazine with a large transition magnetic dipole moment. The hemiporphyrazine ring was opened and one addnl. pyridine unit was introduced, resulting in an overlap of two pyridine rings. X-ray structure anal. confirmed that 12H and its zinc complex (1Zn) adopt a helical geometry. A racemic mixture of 1Zn was resolved into two enantiomers ((P)- and (M)-1Zn), which exhibited CPL with a high luminescence dissymmetry factor (glum) value of ±2.1×10-2. The origin of the large glum value was rationalized by DFT calculations Helical structures could be formed in a diastereoselective manner by covalently attaching chiral units to the skeleton (1’2H and 1’Zn). 1Zn Was found to possess chiral recognition ability for amines. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Reference of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Reference of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Trifluoromethylation/Difluoromethylation-Initiated Radical Cyclization of o-Alkenyl Aromatic Isocyanides for Direct Construction of 4-Cyano-2-Trifluoromethyl/Difluoromethyl-Containing Quinolines》 was written by Mao, Shukuan; Wang, He; Liu, Lu; Wang, Xin; Zhou, Ming-Dong; Li, Lei. Name: fac-Tris(2-phenylpyridine)iridium And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

A radical-triggered cyclization of o-alkenyl aromatic isocyanides prepared from accessible starting materials was developed. The reaction provided a general and efficient method for the synthesis of 4-CN-2-CF3/CF2H-containing quinolines under copper or visible-light photoredox catalysis in a one-pot synthetic procedure. This protocol demonstrated good to high yields, broad substrate scope, and good functional group tolerance. The experimental process involved the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Name: fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Name: fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Construction of visible-light-responsive metal-organic framework with pillared structure for dye degradation and Cr(VI) reduction》 was written by Guo, Zhifen; Zhao, Hongmei; Liu, Xin; Liang, Xiao; Wei, Hongxia; Mei, Yingchun; Xing, Hongzhu. Recommanded Product: 4-Ethynylpyridine And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:

A water-stable mixed-linker metal-organic framework (MOF) was rationally synthesized using a controllable pillared-layer method. The prepared Co(II)-MOF shows wide-range absorption in the visible light region due to the incorporation of highly conjugated anthracene-based bipyridine ligand. Experiments suggest that the MOF is highly efficient for the photoreduction of toxic Cr(VI) ions in water under visible light. Important issues affecting photocatalytic performance, such as the influence of pH and the control of electron-hole separation by scavenger, were carefully examined Beyond Cr(VI) ions, we also explored the photocatalytic degradation performance of the MOF using a persistent azo dye as a model substrate, where H2O2-involved advanced oxidation process was applied. Control experiments suggest that the introduction of environmentally benign H2O2 significantly enhances the degradation performance due to the generation of reactive hydroxyl radicals. The study not only demonstrates the great feasibility of the preparation of a new MOF photocatalyst through a controllable pillared-layer method, but also reveals that rational functionalization of ligand in the MOF is convenient for achieving desirable applications. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Takashima, Chinami; Seino, Junji; Nakai, Hiromi published an article in 2021. The article was titled 《Database-assisted local unitary transformation method for two-electron integrals in two-component relativistic calculations》, and you may find the article in Chemical Physics Letters.Safety of fac-Tris(2-phenylpyridine)iridium The information in the text is summarized as follows:

This letter presents an efficient algorithm for local unitary transformation based on the spin-free infinite-order two-component relativistic method for the two-electron interaction, which is assisted by one-center relativistic two-electron integral (TEI) database. The database stores a set of TEIs, one for each element-basis set combination. The algorithm is numerically assessed for hydrogen halide chains, (HX)n (X = Cl and At), Aun, Ir(ppy)3, Pt3(C7H7)2(HCN)3, and PtCl2(NH3)2. The computational cost (time and memory size) at the Hartree-Fock level is lower than that of the conventional method, especially for small and medium-sized mols.fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Safety of fac-Tris(2-phenylpyridine)iridium) was used in this study.

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Youssef, Heba; Sedykh, Alexander E.; Becker, Jonathan; Schafer, Thomas; Taydakov, Ilya V.; Li, Huanrong R.; Mueller-Buschbaum, Klaus published an article in 2021. The article was titled 《Variable Luminescence and Chromaticity of Homoleptic Frameworks of the Lanthanides together with Pyridylpyrazolates》, and you may find the article in Chemistry – A European Journal.Related Products of 1122-54-9 The information in the text is summarized as follows:

Homoleptic, 3D coordination polymers of the formula 33∞[Ln(3-PyPz)3] and 3∞[Ln(4-PyPz)3], (3-PyPz)- = 3-(3-pyridyl)pyrazolate anion, (4-PyPz)- = 3-(4-pyridyl)pyrazolate anion, both C8H6N3-, Ln = Sm, Eu, Gd, Tb, Dy, were obtained as highly luminescent frameworks by reaction of the lanthanide metals (Ln) with the aromatic heterocyclic amine ligands 3-PyPzH and 4-PyPzH. The compounds form 2 isotypic series of 3D coordination polymers and exhibit fair thermal stability up to 360°. The luminescence properties of all 10 compounds were determined in the solid state, with an antenna effect through ligand-metal energy transfer leading to high efficiency of the luminescence displayed by good quantum yields of up to 74%. The emission is mainly based on ion-specific lanthanide-dependent intra 4f-4f transitions for Tb3+: green, Dy3+: yellow, Sm3+: orange-red, Eu3+: red. For the Gd3+-containing compounds, the yellow emission of ligand triplet-based phosphorescence is observed at room temperature and 77 K. Codoping of the Gd-containing frameworks with Eu3+ and Tb3+ allow further shifting of the chromaticity towards white light emission. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oh, Sangmi; Kwon, Do Yoon; Choi, Inhee; Kim, Young Mi; Lee, Ji Young; Ryu, Jiyoung; Jeong, Hangyeol; Kim, Myung Jin; Song, Rita published an article in 2021. The article was titled 《Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities》, and you may find the article in ACS Medicinal Chemistry Letters.COA of Formula: C5H6BNO2 The information in the text is summarized as follows:

This study evaluated the potential use of senescence-inducing small mols. in the treatment of melanoma. We screened com. available small-mol. libraries with high-throughput screening and high-content screening image-based technol. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogs were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5COA of Formula: C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Shi, Zhaojiang; Lu, Hao-Kuan; Li, Nan; Yuan, Yaofeng; Li, Zhen; Ye, Ke-Yin published an article in Organic Chemistry Frontiers. The title of the article was 《Electrochemical oxidative dearomatization of 2-arylthiophenes》.SDS of cas: 197958-29-5 The author mentioned the following in the article:

A green and sustainable electrochem. oxidative dearomatization of 2-arylthiophenes was reported. The variation of substitution patterns afforded easy access to both C2/C3 and C2/C5 difunctionalized dearomative dihydrothiophenes such as I [R = Ph, 3-FC6H4, 2-pyridyl, etc.; R1 = OAc, OC(O)Et]. The synthetic utility of the resulting dihydrothiophenes was further demonstrated by the concise synthesis of a pyridazinone analog with interesting vasodilator activity. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5SDS of cas: 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem