Pyridine-derivatives

Rai, Roopa; Kolesnikov, Aleksandr; Sprengeler, Paul A.; Torkelson, Steven; Ton, Tony; Katz, Bradley A.; Yu, Christine; Hendrix, John; Shrader, William D.; Stephens, Robin; Cabuslay, Ronnell; Sanford, Ellen; Young, Wendy B. published the artcile< Discovery of novel heterocyclic factor VIIa inhibitors>, Category: pyridine-derivatives, the main research area is aminopyrrolopyridine preparation factor VIIa inhibitor SAR.

Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.

Bioorganic & Medicinal Chemistry Letters published new progress about Anticoagulants. 220731-04-4 belongs to class pyridine-derivatives, and the molecular formula is C10H15N3O2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

McCammant, Matthew S.; Sigman, Matthew S. published the artcile< Development and investigation of a site selective palladium-catalyzed 1,4-difunctionalization of isoprene using pyridine-oxazoline ligands>, Category: pyridine-derivatives, the main research area is pyridine oxazoline ligand preparation; polyene regioselective diastereoselective preparation; isoprene vinyl triflate vinylboronic acid palladium catalyst difunctionalization.

Palladium-catalyzed 1,4-difunctionalizations of isoprene that produce skipped polyenes were reported. Complex isomeric product mixtures were possible as a result of the difficult-to-control migratory insertion of isoprene into a Pd-alkenyl bond, but good site selectivity was achieved using easily accessible pyrox ligands. Mechanistic studies suggest that the control of insertion was the result of the unique electronic asymmetry and steric properties of the ligand.

Chemical Science published new progress about Addition reaction catalysts, stereoselective (regioselective). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Uraguchi, Daisuke; Kinoshita, Natsuko; Kizu, Tomohito; Ooi, Takashi published the artcile< Synergistic Catalysis of Ionic Bronsted Acid and Photosensitizer for a Redox Neutral Asymmetric α-Coupling of N-Arylaminomethanes with Aldimines>, COA of Formula: C33H21F3IrN3, the main research area is aldimine arylaminomethane chiral arylaminophosphonium iridium enantioselective coupling visible light; aryl diamine stereoselective preparation; chiral arylaminophosphonium photosensitizer iridium enantioselective coupling synergistic catalyst.

A redox neutral, highly enantioselective coupling between N-arylaminomethanes and N-sulfonyl aldimines was developed by harnessing the efficient catalysis of P-spiro chiral arylaminophosphonium barfate and a transition-metal photosensitizer under visible light irradiation This mode of synergistic catalysis provides a powerful strategy for controlling the bond-forming processes of reactive radical intermediates.

Journal of the American Chemical Society published new progress about Aldimines Role: RCT (Reactant), RACT (Reactant or Reagent). 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, COA of Formula: C33H21F3IrN3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Connon, Stephen J.; Hegarty, Anthony F. published the artcile< Stabilized 2,3-pyridyne reactive intermediates of exceptional dienophilicity>, Product Details of C6H5BrClNO, the main research area is regioselective lithiation thiophenoxy chloropyridine; thiophenoxy pyridyne preparation; pyridine endoxide preparation.

The enhanced dienophilicity of 4-methoxy, 4-aryloxy and 4-thiophenoxy analogs of 2,3-pyridyne relative to itself is reported. The regioselective lithiation of 4-alkoxy- and 4-thiophenoxy-2-chloropyridine at low temperatures, followed by elimination of lithium chloride affords 4-alkoxy- and 4-thiophenoxypyridynes, which can be trapped in situ in a [4+2] cycloaddition reaction with furan to give endoxides in moderate to good yields (25-58%). In contrast, precursors with a hydrogen or Me substituent at C-4 give no evidence for pyridyne formation under these conditions. Attempts to generate 6-isopropoxy-2,3-pyridyne from the low-temperature lithiation of 2-chloro-6-isopropoxypyridine were unsuccessful due to the instability of the 2-chloro-6-isopropoxy-5-lithiopyridine.

European Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction. 777931-67-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrClNO, Product Details of C6H5BrClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Titi, Abderrahim; Messali, Mouslim; Alqurashy, Bakhet A.; Touzani, Rachid; Shiga, Takuya; Oshio, Hiroki; Fettouhi, Mohammed; Rajabi, Mehdi; Almalki, Faisal A.; Ben Hadda, Taibi published the artcile< Synthesis, characterization, X-ray crystal study and bioactivities of pyrazole derivatives: Identification of antitumor, antifungal and antibacterial pharmacophore sites>, Reference of 21901-29-1, the main research area is pyrazole preparation antitumor antifungal antibacterial human crystal structure mol; pharmacokinetic toxicity pyrazole.

The new pyrazole derivatives I [R = R1 = H, Me; R2 = H, CO2Et; X = C, N; Y = N, CNO2, CCO2H] were synthesized by reaction of hydroxymethyl pyrazole derivatives with primary amines and evaluated for their antifungal, antitumor and antibacterial activities. The structure of synthesized compounds I was identified by FT-IR, UV-visible, proton NMR spectroscopy, mass spectroscopy and single crystal X-ray crystallog. The pyrazoles I [R = R1 = R2 = H, X = Y = N], I [R = R1 = R2 = H, X = C, Y = CCO2H] and I [R = R1 = Me, R2 = CO2Et, X = N, Y = CNO2] were crystallized in space groups C2/c, P21/n and P-1 resp. Crystallog. anal. revealed that N-H of the amine group and nitrogen or oxygen atoms were in-plane with aromatic ring. The aminomethyl chain formed a distorted second plane. The angle between two planes was observed to be 76.07° (N2-C7-N5-N19) for compound I [R = R1 = R2 = H, X = Y = N], 62.12° (N34-C63-N22-N35) for compound I [R = R1 = R2 = H, X = C, Y = CCO2H], 60.84° (N3-C8-N2-N1) and 0.41° (N1-C4-C3-O1/O2) for compound I [R = R1 = Me, R2 = CO2Et, X = N, Y = CNO2]. Theor., phys. and chem. properties calculations had been performed on the pyrazoles I using three different programs: Petra, Osiris and Molinspiration (POM). The geometric parameters of optimized structure were in agreement with exptl. data obtained from X-ray structures.

Journal of Molecular Structure published new progress about Antibacterial agents. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Reference of 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Qingping; Deady, Leslie W. published the artcile< Synthesis of some benzo[b][1,6]naphthyridines and benzo[b][1,7]naphthyridines>, Reference of 55279-29-3, the main research area is benzonaphthyridine methyl; naphthyridine benzo.

Pfitzinger (1-benzylpiperidin-4-one with 7-methylisatin) and Friedlaender (3-aminopyridine-4-carbaldehyde with 2-methylcyclohexanone) syntheses, resp., were used to prepare the title azaacridines I and II containing a Me substituent peri to the central nitrogen. Oxidation of this group gave the corresponding aldehyde and carboxylic acid. In the [1,6] case, especially, the 10-position was also easily oxidized to give acridone analogs. Nitration occurred exclusively in the benzenoid rings.

Australian Journal of Chemistry published new progress about 55279-29-3. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Reference of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Arora, Amandeep; Weaver, Jimmie D. published the artcile< Photocatalytic Generation of 2-Azolyl Radicals: Intermediates for the Azolylation of Arenes and Heteroarenes via C-H Functionalization>, HPLC of Formula: 370878-69-6, the main research area is carbon hydrogen bond activation arylation photocatalysis.

The 2-azolyl radical, generated from 2-bromoazoles via photocatalysis, is a powerful intermediate for the intermol. arylation of unmodified (hetero)arenes. The reaction is characterized by mild conditions, operational simplicity, tolerance toward functional and sterically demanding groups, broad scope, and anti-Minisci selectivity. A working mechanism is provided, and a low-solubility amine is essential for successful coupling. The utility of the reaction is demonstrated via late-stage functionalization of Me estrone and application toward other bromoarenes.

Organic Letters published new progress about C-H bond activation. 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, HPLC of Formula: 370878-69-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Smolyar, N. N.; Yutilov, Yu. M. published the artcile< Reduction of 2-amino-3- and -5-nitropyridine derivatives with hydrazine hydrate>, Name: 6-Amino-3-nitro-2-picoline, the main research area is nitropyridinamine reduction hydrazine hydrate; pyridinamine preparation.

The reactions of 3- and 5-nitro-2-pyridinamine with N2H4.H2O resulted in elimination of the NH2 group and reduction of the NO2 group with formation of 3-pyridinamine. A probable reaction mechanism involves addition of N2H4.H2O to the N-C(2) bond, followed by elimination of NH3 and reduction of the NO2 group to NH2. 4- And 5-methyl-3-nitro-2-pyridinamine reacted with N2H4.H2O in a similar way.

Russian Journal of Organic Chemistry published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Name: 6-Amino-3-nitro-2-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Halevas, Eleftherios; Mavroidi, Barbara; Antonoglou, Orestis; Hatzidimitriou, Antonios; Sagnou, Marina; Pantazaki, Anastasia A.; Litsardakis, George; Pelecanou, Maria published the artcile< Structurally characterized gallium-chrysin complexes with anticancer potential>, Formula: C10H8N2, the main research area is gallium chrysin complex preparation cancer.

Chemotherapeutic metal-based compounds are effective anticancer agents; however, their cytotoxic profile and significant side effects limit their wide application. Natural products, especially flavonoids, are a prominent alternative source of anticancer agents that can be used as ligands for the generation of new bioactive complexes with metal ions of known biochem. and pharmacol. activities. Herein, we present the synthesis and detailed structural and physicochem. characterizations of three novel complex assemblies of Ga(III) with the flavonoid chrysin and the ancillary aromatic chelators 1,10-phenanthroline, 2,2′-bipyridine and imidazole. The complexes constitute the only crystallog. characterized structures having a metal core from the boron group elements and a flavonoid as the ligand. The in vitro biol. evaluation of the three complexes in a series of cancer cell lines of different origin established their cytotoxicity and ROS generating potential. In particular, the Ga(III)-chrysin-imidazole complex displayed the highest anticancer efficacy against all cancer cell lines with IC50 values in the low micromolar range (<1.18 μM), a result worth further investigation. Dalton Transactions published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kim, Sangmin; Loose, Florian; Bezdek, Mate J.; Wang, Xiaoping; Chirik, Paul J. published the artcile< Hydrogenation of N-Heteroarenes Using Rhodium Precatalysts: Reductive Elimination Leads to Formation of Multimetallic Clusters>, Synthetic Route of 3796-23-4, the main research area is phenylpyridinyl benzoquinolinyl cyclometalated pentamethylcyclopentadienylrhodium hydride multinuclear preparation crystal structure; hydrogenation heteroarene rhodium precatalyst reductive multimetallic rhodium cluster; crystal mol structure pentamethylcyclopentadienylrhodium multimetallic cluster.

A rhodium-catalyzed method for the hydrogenation of N-heteroarenes is described. A diverse array of unsubstituted N-heteroarenes including pyridine, pyrrole, and pyrazine, traditionally challenging substrates for hydrogenation, were successfully hydrogenated using the organometallic precatalysts, [(η5-C5Me5)Rh(N-C)H] (N-C = 2-phenylpyridinyl (ppy) or benzo[h]quinolinyl (bq)). In addition, the hydrogenation of polyaromatic N-heteroarenes exhibited uncommon chemoselectivity. Studies into catalyst activation revealed that photochem. or thermal activation of [(η5-C5Me5)Rh(bq)H] induced C(sp2)-H reductive elimination and generated the bimetallic complex, [(η5-C5Me5)Rh(μ2,η2-bq)Rh(η5-C5Me5)H]. In the presence of H2, both of the [(η5-C5Me5)Rh(N-C)H] precursors and [(η5-C5Me5)Rh(μ2,η2-bq)Rh(η5-C5Me5)H] converted to a pentametallic rhodium hydride cluster, [(η5-C5Me5)4Rh5H7], the structure of which was established by NMR spectroscopy, x-ray diffraction, and neutron diffraction. Kinetic studies on pyridine hydrogenation were conducted with each of the isolated rhodium complexes to identify catalytically relevant species. The data are most consistent with hydrogenation catalysis prompted by an unobserved multimetallic cluster with formation of [(η5-C5Me5)4Rh5H7] serving as a deactivation pathway.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent) (N-heteroarenes). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Synthetic Route of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem