Pyridine-derivatives

Fanfoni, Lidia; Marsich, Eleonora; Turco, Gianluca; Breschi, Lorenzo; Cadenaro, Milena published the artcile< Development of di-methacrylate quaternary ammonium monomers with antibacterial activity>, Application of C6H8N2, the main research area is dimethacrylate quaternary ammonium monomer antibacterial activity; Antibacterial monomer; Cytotoxicity; MIC/MBC; Structure-activity relationship; bis-quaternary ammonium salt; di-methacrylate monomer.

Nine antibacterial di-methacrylate monomers based on bis-quaternary ammonium salts (bis-QAMs) were synthesized and structurally characterized. The biol. activity of the bis-QAMs was tested in terms of min. inhibitory concentration (MIC) and min. bactericidal concentration (MBC) on different bacterial strains achieving promising results and, in most cases, a complete bactericidal effect using a bis-QAM concentration lower than 1 mg/mL. Two of the structures showed comparable and superior activity against S. mutans than the com. monomer 12-methacryloyloxydodecyl pyridinium bromide (MDBP). All the bis-QAMs here described were able to inhibit S. mutans biofilm formation at a concentration equal to the MIC value. From the anal. of the obtained data, some correlation regarding the structure and the antibacterial activity of the bis-QAMs could be drawn: a flexible alkyl C12 spacer between the two quaternary ammonium moieties increased the monomer antibacterial effect in comparison to the aromatic ones; the equilibrium between hydrophobic and hydrophilic moieties was directly correlated to the bactericidal range of action; the increase of the steric hindrance of the ammonium side groups might be both advantageous or disadvantageous to the antibacterial efficacy depending on the whole monomer chem. structure. Even though the possible correlation between the monomer structures and their bacteriostatic or bactericidal effect is under investigation, the monomers exhibited low cytotoxicity on human dental pulp stem cells, confirming their promising potential in the dental materials′ field.

Acta Biomaterialia published new progress about Antibacterial agents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Subi, S.; Rose, S. Viola; Reji, T. F. Abbs Fen published the artcile< Synthesis, characterization, DFT study, molecular modelling and biological evaluation of novel 5-aryl-3-(pyridine-3-yl)isoxazole hybrids as potent anticancer agents with inhibitory effect on skin cancer>, Synthetic Route of 350-03-8, the main research area is pyridineyl isoxazole preparation antioxidant antitumor DFT human mol docking.

A novel series of pyridinyl isoxazole derivatives I [Ar = Ph, 4-ClC6H4, 4-MeC6H4, 4-MeOC6H4, PhCH=CH] was synthesized obtained from 5-aryl-3-(pyridine-3-yl)-2-propen-1-ones and hydroxylamine hydrochloride. Geometrical and electronic properties of pyridinyl isoxazole derivative were investigated by using B3LYP/6-31G (d.p) basis sets. The HOMO and LUMO anal. was used to determine the charge transfer within the mol. The pyridinyl isoxazole derivatives I exhibited good docking scores against liver cancer 4MMH. The results revealed clearly compound I [Ar = 4-ClC6H4] exhibited better radical scavenging ability. Among the synthesized pyridinyl isoxazole derivatives, compound I [Ar = 4-ClC6H4] was highly active on the SKMEL cell line (human skin cancer).

Asian Journal of Chemistry published new progress about Antioxidants. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Synthetic Route of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mochizuki, Yuki; Imai, Hiroaki; Oaki, Yuya published the artcile< A Layered Polydiacetylene Containing Hydrogen-Bonding 4,4'-Bipyridyl Guests: Reversible Color Changes with a Wide-Range Temperature Response>, Application of C10H8N2, the main research area is polydiacetylene bipyridyl host guest intercalation hydrogen bonding; host-guest systems; hydrogen bonding; layered compounds; polydiacetylenes; thermoresponsive materials.

Layered organic polymers have intercalation capabilities and dynamic properties. In classical intercalation chem., the interlayer guests are intercalated in the host layers via electrostatic interaction. The present work shows the organic layered materials with the host-guest interlayer interaction via hydrogen bond. Polydiacetylene (PDA) exhibits color changes from blue to red with the application of external stimuli, such as thermal and mech. stresses. Here we report on a layered PDA containing 4,4′-bipyridyl in the interlayer space as a hydrogen-bonding guest. Whereas the layered PDA without interlayer guest shows the color transition at 65°C, gradual color changes with two-stage reversibility are observed in the temperature range of -20-240°C by the introduction of the hydrogen-bonding guest. The weaker interlayer interaction via the hydrogen bond promotes the dynamic motion directing the thermoresponsive color changes in a wide temperature range.

ChemPlusChem published new progress about Color. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Demeng; Wang, Yingwei; Zhang, Xia; Fu, Zhengyan; Niu, Dawen published the artcile< Alkyl/Glycosyl Sulfoxides as Radical Precursors and Their Use in the Synthesis of Pyridine Derivatives>, SDS of cas: 350-03-8, the main research area is pyridine alkyl regioselective preparation; alkyl glycosyl sulfoxide regioselective stereoselective photochem alkylation methoxypyridinium; Alkyl Sulfoxides; C-Glycosides; Electron Donor-Acceptor Complexes; Photochemistry; Radicals.

Here the use of simple and readily available alkyl sulfoxides as precursors to radicals and their application in the preparation of pyridine derivatives are reported. It was shown that alkyl sulfoxides, N-methoxy pyridinium salts and fluoride anions form electron donor-acceptor (EDA) complexes in solution, which, upon visible light irradiation, undergo a radical chain process to afford various pyridine derivatives smoothly. This reaction displays broad scope with respect to both sulfoxides and N-methoxy pyridinium salts. The synthetic versatility of sulfoxides as a handle in chem. adds to their power as radical precursors. Glycosyl sulfoxides are converted to the corresponding pyridyl C-glycosides with high stereoselectivities. Computational and exptl. studies provide insights into the reaction mechanism.

Angewandte Chemie, International Edition published new progress about Alkylation, regioselective. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, SDS of cas: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

den Hertog, H. J.; de Bruyn, J. published the artcile< Derivatives of pyridine and quinoline. LXXXVIII. Reactions of bromo derivatives of 2- and 3-ethoxypyridines when heated with hydrochloric acid>, Safety of 6-Chloropyridin-2-ol, the main research area is .

Following abstract When a bromoethoxypyridine (0.01 mole in 30-40 ml. 25% aqueous HCl) in a sealed tube is heated 4 hrs. at 160° in a shaking furnace, the Br is replaced by Cl when the former is in the 2- or 6-position, and the EtO group is replaced by the OH group. Thus 6-bromo-2-ethoxypyridine (I) gives 6-chloro-2-hydroxypyridine (II), m. 128.5-9°, and 2-bromo-3-ethoxypyridine (III) gives 2-chloro-3-hydroxypyridine, m. 169-70°, plus the corresponding dihydroxypyridines. The 3,5-di-Cl derivative of I yields 3,5,6-trichloro-2-hydroxypyridine, m. 174-5°. When the Br is in the 3- or 5-position it is not substituted by the procedure given. Thus 5-bromo-3-ethoxypyridine yields 5-bromo-3-hydroxypyridine. But either 3- or 5-bromo-2-ethoxypyridine yields mixtures of 3,5-dibromo-2-hydroxypyridine and 2-hydroxypyridine. As a further example of the positional reactivity of the Br, 2,5,6-tri-bromo-3-ethoxypyridine, m. 86-7°, prepared by heating 3-bromo-5-ethoxypyridine with Br in a sealed tube at 100°, gave 5-bromo-2,6-dichloro-3-ethoxypyridine, m. 77-8° with aqueous HCl. The EtO group in this case remained intact.

Recueil des Travaux Chimiques des Pays-Bas et de la Belgique published new progress about Chlorination. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Safety of 6-Chloropyridin-2-ol.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elif Ozturkkan Ozbek, Fureya; Ugurlu, Guventurk; Kalay, Erbay; Necefoglu, Hacali published the artcile< Synthesis, characterization and computational studies of 4-[(Pyridine-3-carbonyl)-hydrazonomethyl]-benzoic acid>, Reference of 93-60-7, the main research area is nicotinohydrazide mol structure hyperpolarizability dipole moment UV NMR IR.

A new hydrazone derivative compound, 4-[(Pyridine-3-carbonyl)-hydrazonomethyl]-benzoic acid, C15H11N3O, was obtained and characterized by 1H NMR, 13C NMR and UV-Vis, FT-IR and FT-Raman spectroscopy techniques. Mol. geometry, vibrational wavenumbers, frontier MO and non-linear optical (NLO) property of the title compound were calculated using ab initio Hartree-Fock (HF) and D. Functional Theory (DFT), employing B3LYP functional at 6-311++G (d,p) basis set. 1H and 13C NMR chem. shifts were calculated by using the gauge in dependent AO (GIAO) method at the HF and B3LYP methods with different basis sets. In addition, the HOMO and the LUMO were obtained from DFT LSDA methods with 6-311++G (d,p) basis set. The NLO behavior of the title compound has been studied by determining the elec. dipole moment (μ) and hyperpolarizability (β) using both B3LYP/6-311++G (d,p) and HF/6-311++G (d,p) methods. The energy gaps s(ΔEgap = ELUMO-EHOMO) of title mol. were calculated at 4.15, 2.77 and 9.81 eV with DFT-B3LYP/6-311++ G (d,p), DFT-LSDA/6-311++ G (d,p) and HF/6-311++ G (d,p) level of theory, resp. The calculated exptl. energy gap was found as 2.827 eV.

Journal of Molecular Structure published new progress about Conformational potential energy surface. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Valipour, Mehdi; Chippindale, Ann M.; Kouzeli, Aynaz; Irannejad, Hamid published the artcile< A new and facile synthesis of N-benzyl-N'-acylureas via reaction of dibenzoylhydrazine carboxamide and benzylamines>, Application In Synthesis of 3731-53-1, the main research area is benzyl acylurea preparation; dibenzoylhydrazine carboxamide benzylamine amination.

Herein, a new method of synthesis of N-acylureas I (Ar = Ph, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, pyridin-3-yl, pyridin-4-yl) via reaction of N,2-bis(4-methoxybenzoyl)hydrazine-1-carboxamide and various benzylamines ArCH2NH2 was reported. Preparation of N,2-bis(4-methoxybenzoyl)hydrazine-1-carboxamide was performed by the treatment of 3-methylthio-5,6-bis(4-methoxyphenyl)-1,2,4-triazine with Oxone which leads to oxidation and triazine ring cleavage in high yield (82%). Five benzylamine derivatives I containing different electron donating and withdrawing substituents were used in this study. Yields for the conversion of dibenzoylhydrazine carboxamide to N-acylureas I were in the range of 40-55%.

Synthetic Communications published new progress about Amides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application In Synthesis of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Siegel, David J.; Howarth, Alexis N.; Traver, Joseph R.; Hillesheim, Patrick C.; Zeller, Matthias; Mirjafari, Arsalan published the artcile< 2,2'-[Methylenebis(sulfanediyl)]bis(pyridine 1-oxide)>, Electric Literature of 3811-73-2, the main research area is pyridine N oxide compound synthesis crystal structure.

The title compound, C11H10N2O2S2, crystallizes with one complete mol. in the asym. unit. In the crystal, weak hydrogen bonding is observed between the N-oxide moieties and several C-H units.

IUCrData published new progress about Crystal structure. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Electric Literature of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nishimura, Nobuko; Norman, Mark H.; Liu, Longbin; Yang, Kevin C.; Ashton, Kate S.; Bartberger, Michael D.; Chmait, Samer; Chen, Jie; Cupples, Rod; Fotsch, Christopher; Helmering, Joan; Jordan, Steven R.; Kunz, Roxanne K.; Pennington, Lewis D.; Poon, Steve F.; Siegmund, Aaron; Sivits, Glenn; Lloyd, David J.; Hale, Clarence; St. Jean, David J. published the artcile< Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 3. Structure-Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N'-arylpiperazine Series>, Recommanded Product: tert-Butyl (5-aminopyridin-2-yl)carbamate, the main research area is arylsulfonamido arylpiperazine glucokinase glucokinase regulatory protein disruptor SAR; AMG 3969 glucokinase glucokinase regulatory protein disruptor SAR; glucose blood level reduction arylsulfonamido arylpiperazine.

We have recently reported a novel approach to increase cytosolic glucokinase (GK) levels through the binding of a small mol. to its endogenous inhibitor, glucokinase regulatory protein (GKRP). These initial investigations culminated in the identification of 2-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (I, AMG-3969), a compound that effectively enhanced GK translocation and reduced blood glucose levels in diabetic animals. Herein we report the results of our expanded SAR investigations that focused on modifications to the aryl carbinol group of this series. Guided by the X-ray cocrystal structure of compound I bound to hGKRP, we identified several potent GK-GKRP disruptors bearing a diverse set of functionalities in the aryl carbinol region. Among them, sulfoximine and pyridinyl derivatives II and III possessed excellent potency as well as favorable PK properties. When dosed orally in db/db mice, both compounds significantly lowered fed blood glucose levels (up to 58%).

Journal of Medicinal Chemistry published new progress about Antidiabetic agents. 220731-04-4 belongs to class pyridine-derivatives, and the molecular formula is C10H15N3O2, Recommanded Product: tert-Butyl (5-aminopyridin-2-yl)carbamate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem