Pyridine-derivatives

Hansen, Andreas; Buse, Anna-Sophie; Wilke, Annika; Skudlik, Christoph; John, Swen M.; Brans, Richard published the artcile< Sensitization to 1,3-diphenylguanidine: An underestimated problem in physicians and nurses using surgical gloves>, Related Products of 123-03-5, the main research area is cetylpyridinium chloride diphenylguanidine surgical gloves; 1,3-diphenylguanidine; allergic contact dermatitis; case report; cetylpyridinium chloride; hand eczema; healthcare workers; patch test; surgical gloves.

This article deals about sensitization to 1,3-diphenylguanidine is underestimated problem in physicians and nurses using surgical gloves. A 55-yr-old male anesthesiologist with hand eczema was patch tested in our department in 2016 revealing sensitization to 1,3-diphenylguanidine and cetylpyridinium chloride. Patch testing of glove was done in three of patients and revealed no pos. reaction. Three of patients were able to continue their occupation with markedly improved skin conditions. No follow-up information was available for female surgeon.

Contact Dermatitis published new progress about Allergic contact dermatitis. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Related Products of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vikram, Venugopalarao; Amperayani, Karteek rao; Ummidi, Venkata Ravi Sankar; Parimi, Umadevi published the artcile< Synthesis, Anti-Microbial Activity, and Docking Studies of Novel N-Pyridine Substituted 2-Chlorothieno[2,3-d]pyrimidine Derivatives>, HPLC of Formula: 55279-29-3, the main research area is pyridine substituted chloro thienopyrimidinamine preparation antibacterial antifungal docking; acetyl coenzyme carboxylase inhibitor pyridine substituted chloro thienopyrimidinamine preparation.

A series of novel N-pyridine substituted 2-chloro-thieno[2,3-d]pyrimidin-4-amine derivatives I [Ar = 2-pyridyl, (3-methyl-2-pyridyl), (5-chloro-2-pyridyl), etc.] had been synthesized and characterized by 1H and 13C NMR spectrometry. All the compounds had been docked against acetyl-CoA carboxylase enzyme and also tested for their in vitro antimicrobial activity on Gram-pos. (Micrococcus luteus, staphylococcus aureus) and Gram-neg. bacteria (Salmonella typhi, klebsiella pneumoniae) and anti-fungal activity on aspergillus niger and fusarium oxysporum. All synthesized compounds have demonstrated moderate activity and two products have exhibited good antibacterial and antifungal activity.

Russian Journal of General Chemistry published new progress about Acetyl-coenzyme A carboxylase inhibitors. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, HPLC of Formula: 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cheung, Chi Wai; Shen, Ni; Wang, Shao-Peng; Ullah, Asim; Hu, Xile; Ma, Jun-An published the artcile< Manganese-mediated reductive amidation of esters with nitroarenes>, Electric Literature of 93-60-7, the main research area is aryl amide; ester nitroarene reductive amidation.

A convenient and efficient method to synthesize N-aryl amides RNHC(O)R1 (R = 4-methylphenyl, 2H-1,3-benzodioxol-5-yl, quinolin-6-yl, etc; R1 = n-C6H13, cyclohexyl, 4-chlorophenyl, pyridin-3-yl, etc.) via amidation of esters R1C(O)OR2 (R2 = Et, benzyl, 2H-1,3-benzodioxol-5-ylmethyl, etc.) with nitroarenes RNO2 was reported. In the presence of manganese metal, this amidation proceeded smoothly without the need for addnl. catalysts or ligands. Various esters and nitroarenes are suitable substrates to afford a wide range of N-aryl amides, including bio-active mols. RNHC(O)R1 (R = 2-phenyl-1,3-benzoxazol-5-yl, R1 = Ph; R = 2-phenyl-1,3-benzoxazol-5-yl, R1 = benzyl) and intermediates I (X = H, Cl) to drug mols. e.g., II.

Organic Chemistry Frontiers published new progress about Amidation (reductive). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Electric Literature of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oelschlegel, Manuel; Hua, Shao-An; Schmid, Lucius; Marquetand, Philipp; Baeck, Anna; Borter, Jan-Hendrik; Luecken, Jana; Dechert, Sebastian; Wenger, Oliver S.; Siewert, Inke; Schwarzer, Dirk; Gonzalez, Leticia; Meyer, Franc published the artcile< Luminescent Iridium Complexes with a Sulfurated Bipyridine Ligand: PCET Thermochemistry of the Disulfide Unit and Photophysical Properties>, SDS of cas: 366-18-7, the main research area is crystallog luminescent iridium complex sulfurated bipyridine ligand; PCET thermochem disulfide unit photophys property.

Mol. systems combining light harvesting and charge storage are receiving great attention in the context of, for example, artificial photosynthesis and solar fuel generation. As part of ongoing efforts to develop new concepts for photoinduced proton-coupled electron transfer (PCET) reactivities, we report a cyclometallated iridium(III) complex [1]+ equipped with our previously developed sulfurated bipyridine ligand S-Sbpy. A new one-step synthetic protocol for S-Sbpy is developed, starting from com. available 2,2′-bipyridine, which significantly facilitates the use of this ligand. The iridium complex [Ir(ppy)2(S-Sbpy)](PF6) ([1]PF6) features a two-electron reduction with potential inversion (|E1| > |E2|) at moderate potentials (E1 = -1.17, E2 = -1.08 V vs. Fc+/0 at 253 K), leading to a dithiolate species [1]-. Protonation with weak acids allows for determination of pKa = 23.5 in MeCN for the S-H···S- unit of [1]H. The driving forces for both the H atom and the hydride transfer are calculated to be ∼ 60 kcal mol-1 and verified exptl. by reaction with a suitable H atom and a hydride acceptor, demonstrating the ability of [1]+ to serve as a versatile PCET reagent, albeit with limited thermal stability. In the MeCN solution, an orange emission for [1]PF6 from a triplet-excited state was found. D. functional calculations and ultrafast absorption spectroscopy are used to give insight into the excited-state dynamics of the complex and suggest a significantly stretched S-S bond for the lowest triplet-state T1. The structural responsiveness of the disulfide unit is proposed to open an effective relaxation channel toward the ground state, explaining the unexpectedly short lifetime of [1]+. These insights as well as the quant. ground-state thermochem. data provide valuable information for the use of S-Sbpy-functionalized complexes and their disulfide-/dithiol-directed PCET reactivity.

Inorganic Chemistry published new progress about Attenuated-total-reflectance IR spectroscopy. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kress, Thomas J.; Moore, Larry L.; Costantino, Silvio M. published the artcile< Selective chlorinations in sulfuric acid. Synthesis of some 2-amino-5-chloro-, 2-amino-3-chloro-, and 2-amino-3,5-dichloropyridines>, Application In Synthesis of 22280-62-2, the main research area is pyridine amino chlorination; chlorination aminopyridine sulfuric acid.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. 2-Aminopyridine and a number of Me substituted 2-aminopyridines underwent selective chlorination. The chlorination of 2-aminopyridine at various H2SO4 concentrations and the distribution of chlorinated products was studied in detail. With increasing acidity dichlorination decreases, and in 72% H2SO4 only traces of dichlorination occur. The selectivity of the chlorination reaction is ascribed to differences in the rate of chlorination of protonated vs nonprotonated substrates.

Journal of Organic Chemistry published new progress about Chlorination. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Application In Synthesis of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Zhijie; Qiao, Yuanyuan; Li, Miaomiao; Ma, Pengtao; Niu, Jingyang; Wang, Jingping published the artcile< Two synthetic routes generate two isopolyoxoniobates based on {Nb16} and {Nb20}>, Safety of 2,2′-Bipyridine, the main research area is copper bipyridine isopolyoxoniobate preparation thermal stability; crystal structure copper bipyridine isopolyoxoniobate.

Self-assembly reactions of the Lindqvist-ion salt K7HNb6O19·13H2O, SeO2, and [Cu(2,2′-bipy)]2+ give, depending on different routes, two isopolyoxoniobates based on {Nb16} and {Nb20}, resp., which, as new members of the very limited isopolyoxoniobate family, are observed for the 1st time. Also, the solution behavior was studied to determine the stability of the {Nb16} cluster in water.

Dalton Transactions published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xiang; Jin, Jianbo; Chen, Pinhong; Liu, Guosheng published the artcile< Catalytic remote hydrohalogenation of internal alkenes>, Reference of 3796-23-4, the main research area is primary alkyl halide preparation palladium catalyst; terminal internal alkene hydrohalogenation.

Abstract: Primary alkyl halides have broad utility as fine chems. in organic synthesis. The direct halogenation of alkenes is one of the most efficient approaches for the synthesis of these halides. Internal alkenes, in particular mixtures of isomers from refineries, constitute readily available and inexpensive feedstock and are the most attractive starting materials for this synthesis. However, the hydrohalogenation of alkenes generally affords branched alkyl halides; there are no catalytic methods to prepare linear alkyl halides directly from internal alkenes, let alone from a mixture of alkene isomers. Here a report the remote oxidative halogenation of alkenes under palladium catalysis via which both terminal and internal alkenes yield primary alkyl halides efficiently. Engineering pyridine-oxazoline ligands by introducing a hydroxyl group is essential for achieving excellent chemo- and regioselectivity. The catalytic system is also good for the mixture of alkene isomers generated from dehydrogenation of alkanes, providing a window to investigate the high-value utilization of inexpensive alkanes.

Nature Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Reference of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vydzhak, Roman N.; Panchishin, Svitlana Ya.; Kachaeva, Maryna V.; Pilyo, Stepan G.; Moskvina, Viktoriia S.; Shablykina, Olga V.; Kozytskiy, Andriy V.; Brovarets, Volodymyr S. published the artcile< Rapid synthetic approaches to libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones and 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones>, Application of C6H8N2, the main research area is dihydrochromenopyrrole dione preparation; hydroxyphenyl dihydropyrrolopyrazolone preparation; Chromeno[2,3-c]pyrroles; Combinatorial library; Dihydrochromeno[2,3-c]pyrrole-3,9-diones; Dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones; Multicomponent cyclization.

An efficient and practical synthetic procedure for libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones I [R =H, 6,7-di-Me, 7-F, etc.; R1 = n-Pr, CH2CH2OH, 2-furylmethyl, etc.; Ar = Ph, 4-MeC6H4, 3,4,5-tri-MeOC6H2, etc.] using a multicomponent process was presented. A convenient synthetic procedure for obtaining functionalized 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones II [R2 = H, 3,5-di-Me, 4-Me-5-Cl, etc.; R3 = 4-BrC6H4, 2-OHC6H4, 3-MeO-4-OHC6H3, etc.; R4 = n-Pr, CH2CH2OH, 2-ClC6H4CH2, etc.] via ring-opening strategy was developed. This protocol was found to be compatible with a wide range of substituents and paves the way for the practical synthesis of title compounds with a broad range of substituents under mild condition. The products could be easily isolated by crystallization without the use of chromatog.

Molecular Diversity published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pegu, David; Singh, Ngangbam Bedamani published the artcile< Quantum chemical calculations of molecular structure, electronic, thermodynamic and non-linear optical properties of 2-amino-3-nitro-6-methyl pyridine>, Name: 2-Amino-3-nitro-6-picoline, the main research area is amino nitro methyl pyridine mol structure hyperpolarizability.

In the present study, we report a theor. study on mol. structure, electronic and thermodynamical properties of 2-amino-3-nitro-6-Me pyridine (2A3N6MP) by using ab initio Hartree Fock (HF) and d. functional theory (DFT) methods employing B3LYP exchange correlation with 6-311++G(d,p) basis set. The ground state mol. geometrical parameters, have been calculated and compared with available reported values. The calculated HOMO and LUMO energy shows that charge transfer takes place within the mol. and the mol. is chem. soft mol. The dipole moment, linear polarizability and first hyperpolarizability values were also computed. Finally the temperature dependence thermodn. properties were also determined and interpreted.

International Journal of Advanced Research published new progress about Dipole moment. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Name: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kuzuya, Masayuki; Noguchi, Akihiro; Mano, Eiichi; Okuda, Takachiyo published the artcile< The structure-reactivity-chemoselectivity relationship on the reactions of 1-unsubstituted tautomeric 2-pyridones with benzyne>, Product Details of C5H4ClNO, the main research area is tautomerism pyridone reaction benzyne.

The effect of tautomerism of 2-pyridones on the products obtained in reaction with benzyne was studied. Both Diels-Alder and Michael-type adducts were formed. The Diels-Alder reactivities were correlated with HOMO energy levels of the 2-pyridone form; the yields of the Michael-type adducts were associated with the tautomeric equilibrium Substituent effects on the tautomerism were discussed.

Bulletin of the Chemical Society of Japan published new progress about CNDO/2 (molecular orbital method). 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Product Details of C5H4ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem