Pyridine-derivatives

Hara, Naofumi; Aso, Koki; Li, Qiao-Zhi; Sakaki, Shigeyoshi; Nakao, Yoshiaki published the artcile< C2-selective alkylation of pyridines by rhodium-aluminum complexes>, Application of C11H16BNO2, the main research area is pyridine alkylation alkene vinylsilane CH activation rhodium aluminum catalyst; alkylpyridine preparation alkylation CH activation vinylsilane alkene bimetallic catalyst.

A C2- and mono-selective alkylation of various pyridines and azines with unactivated alkenes and vinylarenes using a heterobimetallic Rh-Al catalyst is reported. The use of aliphatic alkenes exclusively affords the linear alkylation products, while vinylarenes mainly afford branched alkylation products. The details of the reaction mechanism are revealed by DFT calculations: the reductive elimination of the products is rate-determining, which is consistent with the exptl. results. The origin of the linear/branched selectivity is elucidated based on deformation/interaction anal.

Tetrahedron published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Application of C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tsai, Meng-Jung; Luo, Jheng-Hua; Wu, Jing-Yun published the artcile< Two-fold 2D + 2D → 2D interweaved rhombus (4,4) grid: synthesis, structure, and dye removal properties in darkness and in daylight>, Category: pyridine-derivatives, the main research area is pyridinylmethylpyridinyl naphthalimide copper coordination polymer preparation structure rhombus grid.

Compound [Cu(NI-mbpy-44)2(NO3)2]·4H2O (1, NI-mbpy-44 = N-(pyridin-4-ylmethyl)-4-(pyridin-4-yl)-1,8-naphthalimide) adopting a two-dimensional (2D) periodical rhombus (4,4) grid has been synthesized. This grid doubly interweaves in a parallel fashion to result in overall 2D + 2D → 2D networks with approx. 14% sufficient free volumes in which lattice H2O mols. reside. Dye removal studies show that 1 selectively adsorbs anionic methyl orange (MO) and acid orange 7 (AO7) over cationic methylene blue (MB) and malachite green (MG) from aqueous solutions containing single or mixed dyes in darkness at room temperature The exptl. isotherm data were analyzed using linear Langmuir and Freundlich isotherm equations; the results indicated that the Langmuir model showed a better fit for the adsorption of MO and AO7 over 1, with high dark adsorption capacities of 810 and 370 mg g-1, resp., although there could also be other associated mechanisms. The dark adsorption kinetics of MO and AO7 over 1 obeyed the pseudo-second-order kinetic model. Electrostatic attraction appears to be the dominating mechanism for adsorptive removal of MO and AO7 by 1, whereas π-π stacking (MO and AO7) and hydrogen-bonding interactions (AO7) could also be responsible. Exploration of the adsorption performance of MO and AO7, including studying the kinetics in daylight, shows similar results to those obtained in darkness, indicating the negligible influence of daylight on the dye removal. Nevertheless, 1 could liberate NI-mbpy-44 and Cu(II) into water throughout the entire adsorption experiment, which could be a potential environmental hazard, this could cause secondary pollution and mean that 1 is impractical for use as an adsorbent candidate.

Dalton Transactions published new progress about Adsorbents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shipe, William D.; Sharik, Steven S.; Barrow, James C.; McGaughey, Georgia B.; Theberge, Cory R.; Uslaner, Jason M.; Yan, Youwei; Renger, John J.; Smith, Sean M.; Coleman, Paul J.; Cox, Christopher D. published the artcile< Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis>, Application In Synthesis of 56622-54-9, the main research area is pyrimidine derivative PDE10A inhibitor screening discovery preparation structure.

Screening of a fragment library for PDE10A inhibitors identified a low mol. weight pyrimidine hit with PDE10A Ki of 8700 nM and LE of 0.59. Initial optimization by catalog followed by iterative parallel synthesis guided by X-ray cocrystal structures resulted in rapid potency improvements with minimal loss of ligand efficiency. Compound 15h, with PDE10A Ki of 8.2 pM, LE of 0.49, and >5000-fold selectivity over other PDEs, fully attenuates MK-801-induced hyperlocomotor activity after i.p. dosing.

Journal of Medicinal Chemistry published new progress about Antipsychotics. 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Application In Synthesis of 56622-54-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Johannes, Jeffrey W.; Balazs, Amber; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, Sebastien L.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Martin, Scott; McWilliams, Lisa; O′Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andrew; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan published the artcile< Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs>, SDS of cas: 53636-56-9, the main research area is chloroquinazolinone aryl piperazine carboxamide AZD5305 syntesis anticancer PARP1.

Poly-ADP-ribose-polymerase (PARP) inhibitors have achieved regulatory approval in oncol. for homologous recombination repair deficient tumors including BRCA mutation. However, some have failed in combination with first-line chemotherapies, usually due to overlapping hematol. toxicities. Currently approved PARP inhibitors lack selectivity for PARP1 over PARP2 and some other 16 PARP family members, and we hypothesized that this could contribute to toxicity. Recent literature has demonstrated that PARP1 inhibition and PARP1-DNA trapping are key for driving efficacy in a BRCA mutant background. Herein, we describe the structure- and property-based design of AZD5305, I, a potent and selective PARP1 inhibitor and PARP1-DNA trapper with excellent in vivo efficacy in a BRCA mutant HBCx-17 PDX model. Compound 25 is highly selective for PARP1 over other PARP family members, with good secondary pharmacol. and physicochem. properties and excellent pharmacokinetics in preclin. species, with reduced effects on human bone marrow progenitor cells in vitro.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, SDS of cas: 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pang, Jia Hao; Kaga, Atsushi; Roediger, Sven; Lin, Min Htoo; Chiba, Shunsuke published the artcile< Revisiting the Chichibabin Reaction: C2 Amination of Pyridines with a NaH-Iodide Composite>, COA of Formula: C10H8N2, the main research area is pyridine preparation Chichibabin.

A NaH-iodide composite was found capable of mediating the Chichibabin amination under mild reaction conditions, allowing efficient access to a range of 2-aminopyridines and their derivatives

Asian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Yu; Wang, Ruo-Ya; Kang, Jia-Xin; Ma, Yan-Na; Xu, Cong-Qiao; Li, Jun; Chen, Xuenian published the artcile< Efficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes>, Formula: C7H7NO2, the main research area is primary secondary amide preparation chemoselective; ester sodium amidoborane amidation.

Authors report here a facile synthesis method of primary and secondary amides through a direct amidation of esters with sodium amidoboranes (NaNHRBH3, R = H, Me), at room temperature without using catalysts and other reagents. This process is rapid and chemoselective, and features quant. conversion and wide applicability for esters tolerating different functional groups. The exptl. and theor. studies reveal a reaction mechanism with nucleophilic addition followed by a swift proton transfer-induced elimination reaction.

Nature Communications published new progress about Amidation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Haixia; Robl, Jeffrey A.; Hamann, Lawrence G.; Simpkins, Ligaya; Golla, Rajasree; Li, Yi-Xin; Seethala, Ramakrishna; Zvyaga, Tatyana; Gordon, David A.; Li, James J. published the artcile< Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)>, Category: pyridine-derivatives, the main research area is triazolopyridine derivative inhibitor human hydroxysteroid dehydrogenase.

A series of pyridyl amide/sulfonamide inhibitors of 11β-HSD-1 were modified to incorporate a novel 1,2,4-triazolopyridine scaffold. Optimization of substituents at the 3 and 8 position of the TZP core, with a special focus on enhancing metabolic stability, resulted in the identification of compound 38 as a potent and metabolically stable inhibitor of the enzyme.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Wenjun; Chernyshov, Ivan Yu.; van Schendel, Robin K. A.; Weber, Manuela; Mueller, Christian; Filonenko, Georgy A.; Pidko, Evgeny A. published the artcile< Robust and efficient hydrogenation of carbonyl compounds catalysed by mixed donor Mn(I) pincer complexes>, Application In Synthesis of 350-03-8, the main research area is alc preparation; carbonyl compound hydrogenation manganese catalyst.

A highly efficient Mn(I)-CNP pre-catalyst I which gives rise to the excellent productivity (TOF° up to 41 000 h-1) and stability (TON up to 200 000) in hydrogenation catalysis was reported. This system enables near-quant. hydrogenation of ketones RC(O)R1 (R = Ph, 2,3-dihydro-1,4-benzodioxin-6-yl, pentyl, etc.; R1 = Et, Bn, cyclopropyl, etc.; RR1 = -(CH2)5-) and 1,2,3,4-tetrahydronaphthalen-1-one, imines 4-R2C6H4N=CHC6H5 (R2 = H, Br, OMe), aldehydes R3CHO [R3 = Ph, 4-(dimethylamino)phenyl, 4-(benzyloxy)phenyl, furan-2-yl] and formate esters R4OC(O)H (R4 = hexyl, pentyl, 3-methylbutyl) at the catalyst loadings as low as 5-200 p.p.m. The anal. points to the crucial role of the catalyst activation step for the catalytic performance and stability of the system. While conventional activation employing alkoxide bases can ultimately provide catalytically competent species under hydrogen atm., activation of Mn(I) pre-catalyst I with hydride donor promoters, e.g., KHBEt3, dramatically improves catalytic performance of the system and eliminates induction times associated with slow catalyst activation.

Nature Communications published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

De Vos, Arthur; Lejaeghere, Kurt; Muniz Miranda, Francesco; Stevens, Christian V.; Van Der Voort, Pascal; Van Speybroeck, Veronique published the artcile< Electronic properties of heterogenized Ru(II) polypyridyl photoredox complexes on covalent triazine frameworks>, Reference of 366-18-7, the main research area is electronic property heterogenized ruthenium polypyridyl photoredox complex covalent triazine.

Ru(II) polypyridyl complexes have been successful for a wide range of photoredox applications thanks to their efficient light-induced metal-to-ligand charge transfer. Using the computational framework of d.-functional theory, we report how these complexes can be anchored onto covalent triazine frameworks while maintaining their favorable electronic properties. We moreover show that variation of the nitrogen content of the framework linkers or complex ligands endows the heterogenized catalyst with a unique versatility, spanning a wide range of absorption characteristics and redox potentials. By judiciously choosing the catalyst building blocks, it is even possible to selectively guide the charge transfer toward either the scaffold or the accessible pore sites. Rational design of sustainable and efficient photocatalysts thus comes within reach.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Coordination compounds Role: CAT (Catalyst Use), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), USES (Uses), PREP (Preparation). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Reference of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Yanjun; Ye, Ziqi; Lin, Yu-Mei; Liu, Yan; Zhang, Yumeng; Gong, Lei published the artcile< Organophotocatalytic selective deuterodehalogenation of aryl or alkyl chlorides>, Quality Control of 329214-79-1, the main research area is deuterated aryl heteroaryl compound green preparation; aryl chloride alkyl organophotocatalyst selective deuterodehalogenation.

A photocatalytic system consisting of an aryl-amine photocatalyst and a disulfide co-catalyst in the presence of sodium formate as an electron and hydrogen donor was developed. Accordingly, many aryl chlorides, alkyl chlorides, and other halides were converted to deuterated products at room temperature in air (>90 examples, up to 99% D-incorporation). The mechanistic studies revealed that the aryl amine served as reducing photoredox catalyst to initiate cleavage of the C-Cl bond, at the same time as energy transfer catalyst to induce homolysis of the disulfide for consequent deuterium transfer process. This economic and environmentally-friendly method could be used for site-selective D-labeling of a number of bioactive mols. and direct H/D exchange of some drug mols.

Nature Communications published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Quality Control of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem