Pyridine-derivatives

Application of 887707-23-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 887707-23-5, name is 2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below.

(0614) A mixture of Compound 37C (0.537 g), 5-iodo-3-(trifluoromethyl)pyridin-2-ol (1.156 g), and triphenylphosphine (1.574 g) in tetrahydrofuran (20 ml) was cooled to 0 C. To this solution was added (E)-di-tert-butyl diazene-1,2-dicarboxylate (0.921 g). The reaction mixture was stirred overnight. The solvent was removed, and the residue was purified with column flash chromatography on silica gel eluting with 4:1 hexanes/ethyl acetate to give the desired product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,887707-23-5, 2-Hydroxy-5-iodo-3-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; AbbVie Inc.; Catron, Nathaniel; Lindley, David; Miller, Jonathan M.; Schmitt, Eric A.; Tong, Ping; US10213433; (2019); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 185017-72-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.185017-72-5, name is 3-Bromo-2-chloro-6-picoline, molecular formula is C6H5BrClN, molecular weight is 206.4676, as common compound, the synthetic route is as follows.

Example 52; (RS)-1-Benzenesulfonyl-4-[4-(3-bromo-6-methyl-pyridin-2-yl)-piperazine-1-carbonyl]-3-cyclohexyl-imidazolidin-2-oneStep 1: A solution of 3-bromo-2-chloro-6-picoline (0.2 g), piperazine (0.083 g) and triethylamine (0.096 g) in acetonitrile (5 ml) was heated in the microwave apparatus: 30 min at 120 C. followed by 60 min at 150 C. and 30 min at 170 C. The mixture was concentrated and the product was purified by chromatography (SiO2, CH2Cl2=>CH2Cl2/CH3OH 4:1) to give 1-(3-bromo-6-methyl-pyridin-2-yl)-piperazine (0.05 g) as a light yellow solid.

Statistics shows that 185017-72-5 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-2-chloro-6-picoline.

Reference:
Patent; Dehmlow, Henrietta; Kuhn, Bernd; Sander, Ulrike Obst; Roever, Stephan; Schulz-Gasch, Tanja; Wright, Matthew; US2008/242677; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 24059-83-4, Adding some certain compound to certain chemical reactions, such as: 24059-83-4, name is Methyl 3-methoxypyridine-2-carboxylate,molecular formula is C8H9NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24059-83-4.

The reaction mixture of compound 5 (261 mg, 1.56 mmol), NaOH (281 mg, 7.03 mmol) in MeOH (9 mL) and water (6 mL) was stirred at rt for 1.5 h. The solvent was removed under reduced pressure and the residue was diluted with water. The solution was extracted with EtOAc (5 times). The organic phases were combined and evaporated under vacuum to give 6 as a light yellow solid. 1H NMR (300 MHz, CD3OD) delta 8.18 (s, 1H), 7.78 (d, J = 8.3 Hz, 1H), 7.67 (s, 1H), 3.96 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 24059-83-4, Methyl 3-methoxypyridine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Feng-Hua; Debnath, Bikash; Xu, Zhong-Liang; Yang, Liu-Meng; Song, Li-Rui; Zheng, Yong-Tang; Neamati, Nouri; Long, Ya-Qiu; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1051 – 1063;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77199-09-8, name is Ethyl 5-bromopicolinate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 77199-09-8

2-Amino-5-fluoro-4-(l-isopropyl-2-methyl-lH-imidazol-5-yl)pyrimidine (Method 1 ; 517mg, 2.2mmol), ethyl 5-bromopyridine-2-carboxylate (460.12mg, 2mmol), EPO tris(dibenzylideneacetone)dipalladium(0) (18.31mg, lmol%), Xantphos (25.5mg, 2.2mol%) and caesium carbonate (912.3mg, 2.8mmol) in anhydrous 1,4-dioxane (8ml) were evacuated and refilled with nitrogen (3 times). The reaction was heated under nitrogen at 100C for 3.5h. Extra tris(dibenzylideneacetone)dipalladium(0) (18.31mg, lmol%) and Xantphos (25.5mg, 2.2mol%) were added and the reaction mixture was heated under nitrogen at 1000C overnight before evaporating under reduced pressure. The residue obtained was partitioned between DCM and water and the aqueous layer was extracted with DCM twice. The organics were combined, washed with brine, dried and the solvent was evaporated to give a foam which was purified by reverse phase chromatography (acidic prep HPLC system). The product containing fractions were passed through a pre-equilibrated Isolute SCX-2 column, eluted with MeOH, and a 7 molar solution of ammonia in MeOH. Evaporation of solvent gave the title compound as a solid which was dried in vac oven overnight at 5O0C (540mg, 70%). NMR (400MHz): 1.33 (t, 3H), 1.48 (d, 6H), 2.54 (s, 3H), 4.32 (q, 2H), 5.39 (septet, IH), 7.41 (d, IH), 8.02 (d, IH), 8.35 (dd, IH), 8.67 (d, IH), 8.91 (d, IH), 10.16 (s, IH); 17F NMR (400MHz): -145.98 (t, IF); m/z 385.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 77199-09-8, Ethyl 5-bromopicolinate.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/95159; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 56673-34-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56673-34-8, name is 3-Bromo-6-mercaptopyridine, molecular formula is C5H4BrNS, molecular weight is 190.06, as common compound, the synthetic route is as follows.

A suspension of 5-bromo-pyridine-2-thiol (which may be prepared as described for Intermediate 1.05; 2 g, 10.5 mmol) in carbon tetrachloride (40 mL) and water (8 mL) was cooled to 0 C. using an ice-bath. Chlorine gas was bubbled through the reaction mixture for 20 min and then CH2Cl2 (100 mL) was added. The mixture was washed with brine. The organic layer was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure to give 5-bromo-pyridine-2-sulfonyl chloride (1.92 g, 71%) as a light yellow solid which was used directly in the next step without further purification. NMR (400 MHz, DMSO-d6) delta: 8.63 (d, J=1.5 Hz, 3H), 8.07 (dd, J=8.3, 2.2 Hz, 3H), 7.68 (d, J=8.3 Hz, 3H).

Statistics shows that 56673-34-8 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-6-mercaptopyridine.

Reference:
Patent; Firooznia, Fariborz; Gillespie, Paul; Lin, Tai-An; So, Sung-Sau; US2012/309796; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108118-69-0, name is 2,6-Difluoropyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2,6-Difluoropyridin-3-amine

The mixture of methyl (3R,4S)- 1 -methyl-2-oxo-4- [4-(trifluoromethyl)phenyll -3- pyrrolidinecarboxylate (i.e. the product obtained in Step D above) (5 g, 16.6 mmol), 2,6- difluoropyridin-3-amine (2.37 g, 18.2 mmol) and xylene (45 mL) was heated to the refluxtemperature (142 C) for 10 h, while the methanol generated was distilled out to maintain the pot temperature at 142 C. The progress of reaction was monitored by HPLC until the conversion was greater than 97%. The mixture was concentrated under reduced pressure and purified by silica gel colunm chromatography, eluting with 35% ethyl acetate in hexanes to provide 5.88 g of an off-white solid, which was recrystallized from a mixture of n-chlorobutane (50 mL) and hexanes 75 mL to afford the title product (2.3 g, 99.8% e.e.) as white solid.1H NMR oe 3.02 (s, 3H), 3.48 (dd, 1H), 3.64 (d, 1H), 3.81 (dd, 1H), 4.12 (q, 1H), 6.78 (dd,1H), 7.49 (d, 2H), 7.65 (d, 2H), 8.72 (m, 1H), 10.07 (s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 108118-69-0, 2,6-Difluoropyridin-3-amine.

Reference:
Patent; FMC CORPORATION; CHEN, Yuzhong; (56 pag.)WO2018/175226; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 271-29-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.271-29-4, name is 1H-Pyrrolo[2,3-c]pyridine, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.

1.1 7.0 g (106 mmol) of potassium hydroxide pellets are added to a solution of 5.00 g (42.3 mmol) of 1H-pyrrolo[2,3-c]pyridine in 80 ml of DMF, and a solution of 10.9 g (42.7 mmol) of iodine in 80 ml of DMF is added dropwise thereto at room temperature and with stirring and stirred for 45 minutes. A solution of 5 ml of 32% ammonia and 1 g of sodium disulfite in 1 l of water is added to the reaction mixture. The resultant precipitate is filtered off with suction, washed with water and dried in vacuo, giving 3-iodo-1H-pyrrolo-[2,3-c]pyridine as orange-yellow solid; ESI 245.

Statistics shows that 271-29-4 is playing an increasingly important role. we look forward to future research findings about 1H-Pyrrolo[2,3-c]pyridine.

Reference:
Patent; Merck Patent Gesellschaft Mit Beschrankter Haftung; US2010/292262; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 886373-28-0, Adding some certain compound to certain chemical reactions, such as: 886373-28-0, name is 5-Bromo-3-fluoropicolinonitrile,molecular formula is C6H2BrFN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 886373-28-0.

Cone. HCl (300 mL) were added to 5-Bromo-3-fluoro-pyridine-2-carbonitrile (21.0 g,0.11 mol) and stirred over night at 600C. After evaporation ether was added and the suspension was stirred for additional time. The solid was collected and dried. The crude product was used without any further purification. MS (m/z): 219.8 [M+H*]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 886373-28-0, 5-Bromo-3-fluoropicolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JERINI AG; WO2009/36996; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.75711-01-2, name is 6-Chloro-5-methoxypyridin-3-amine, molecular formula is C6H7ClN2O, molecular weight is 158.59, as common compound, the synthetic route is as follows.SDS of cas: 75711-01-2

a 2-Chloro-3-methoxypyridin-5 -amine (500 mg, 3.15 mmol; Eastman Kodak US patent US4204870, column 38) and triethyl orthoformate (3.04 ml, 18.29 mmol) under a dry atmosphere was stirred at 145 0C for 1 hour. The solution was cooled to room temperature and concentrated. The residue was dried under high vacuum overnight, dissolved in ethanol (5 ml). Sodium borohydride (143 mg, 3.78 mmol) was added to this solution. The resulting mixture was stirred at 800C for 1 hour. The reaction mixture was concentrated and quenched with ice and water (20ml). Concentrated hydrochloric acid (0.5 ml) was added. The pH of solution was adjusted to pH 7 with sodium bicarbonate and the mixture was extracted with ethyl acetate (x3) The combined organic phases were washed with water, dried over sodium sulfate and concentrated. The crude product was purified by flash chromatography on silica gel eluting with 25 to 30% ethyl acetate in petroleum ether. The solvent was evaporated to dryness to afford 6-chloro-5 -me thoxy-N-methylpyridin-3 -amine (357 mg, 65.6%) as a beige solid. NMR Spectrum: (DMSOd) 2.71 (d, 3H), 3.82 (s, 3H), 6.07 (q, IH), 6.65 (d, IH), 7.28 (d, IH); Mass spectrum: MH+ 173.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75711-01-2, 6-Chloro-5-methoxypyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/10794; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 88912-24-7, name is 5,6-Dichloropicolinic acid, the common compound, a new synthetic route is introduced below. Safety of 5,6-Dichloropicolinic acid

EXAMPLE 14 5,6-bis(ethylthio)-2-pyridinecarboxylic acid Potassium t-butoxide (111 g) was stirred in 200 ml of DMSO under N2. The reaction vessel was cooled with an ice bath while ethanethiol (43 g) was added, and the mixture was stirred for 30 minutes. The cold bath was removed, and 5,6-dichloro-2-pyridinecarboxylic acid (55 g) in 300 ml of DMSO was added. The mixture was stirred at 75 C. for 20 hours. After cooling, the mixture was added to 2 liters of ice water, then acidified with concentrated HCl. The white solid which formed was collected and dried to give 66.15 g of the crude product. A portion of the crude product was recrystallized from isopropanol which gave purified 5,6-bis(ethylthio)-2-pyridinecarboxylic acid, m.p. 112-113 C. Other bis(R-thio)pyridines were prepared by the decarboxylation of the appropriate bis(R-thio)-2-pyridinecarboxylic acid using the procedures described herein. These compounds are:

The synthetic route of 88912-24-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Dow Chemical Company; US4616087; (1986); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem