Tuberculostatic substances from derivatives of pyridinecarboxylic acids was written by Palat, Karel;Celadnik, Milan;Novacek, Libor;Polster, Miroslav;Urbancik, Richard;Matuskova, Elsa. And the article was included in Acta Fac. Pharm. Brun. Bratislav. in 1962.Reference of 89978-52-9 This article mentions the following:
Among various hydrazides, amides, thioamides, hydroxamic acids, and Na salts of pyridinecarboxylic acids substituted in the ring by alkoxy, hydroxy, mercapto, or halogen, the greatest activity in vitro was shown by the hydrazide of 2,6-diethoxyisonicotinic acid, partly effective in a concentration 0.1 γ/ml. completely inhibitive of growth in a concentration of 1 γ/ml. Also effective were 2-propoxynicotinic acid hydrazide, active at 1 γ/ml., and 3- bromoisonicotinic acid hydrazide, active at 10 γ/ml. In vivo, the most effective was Na 3-iodoisonicotinate, which was inactive in vitro. In the experiment, the researchers used many compounds, for example, Ethyl 2-bromoisonicotinate (cas: 89978-52-9Reference of 89978-52-9).
Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Reference of 89978-52-9