Synthesis of Trisubstituted Pyridines via Chemoselective Suzuki-Miyaura Coupling of 3,5- and 4,6-Dibromo-2-tosyloxypyridines was written by Park, Cho-Hee;Kwon, Yong-Ju;Oh, In-Young;Kim, Won-Suk. And the article was included in Advanced Synthesis & Catalysis in 2017.Safety of 3,5-Dibromo-2-hydroxypyridine This article mentions the following:
Chemoselective Suzuki-Miyaura reactions on 3,5- and 4,6-dibromo-2-tosyloxypyridines was studied for the preparation of trisubstituted pyridines I [Ar = Ph, 3-thienyl, 2-benzothiophenyl, etc.] and II. Further functionalization such as palladium-catalyzed amination and copper-free Sonogashira reaction of the tosylate group in the diarylpyridine derivatives obtained was accomplished for the synthesis of novel and biol. relevant trisubstituted pyridines. The formal synthesis of ficuseptine, a bioactive alkaloid, was also achieved via palladium-catalyzed cross-coupling reaction of 3,5-dibromo-2-tosyloxypyridine from 3,5-dibromo-2-hydroxypyridine with 50% overall yield. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Safety of 3,5-Dibromo-2-hydroxypyridine).
3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of 3,5-Dibromo-2-hydroxypyridine