Exceptional Substrate Diversity in Oxygenation Reactions Catalyzed by a Bis(μ-oxo) Copper Complex was written by Paul, Melanie;Teubner, Melissa;Grimm-Lebsanft, Benjamin;Golchert, Christiane;Meiners, Yannick;Senft, Laura;Keisers, Kristina;Liebhaeuser, Patricia;Roesener, Thomas;Biebl, Florian;Buchenau, Soeren;Naumova, Maria;Murzin, Vadim;Krug, Roxanne;Hoffmann, Alexander;Pietruszka, Joerg;Ivanovic-Burmazovic, Ivana;Ruebhausen, Michael;Herres-Pawlis, Sonja. And the article was included in Chemistry – A European Journal in 2020.HPLC of Formula: 626-64-2 This article mentions the following:
The enzyme tyrosinase contains a reactive side-on peroxo dicopper(II) center as catalytically active species in C-H oxygenation reactions. The tyrosinase activity of the isomeric bis(μ-oxo) dicopper(III) form has been discussed controversially. The synthesis of bis(μ-oxo) dicopper(III) species [Cu2(μ-O)2(L1)2](X)2 ([O1](X)2, X = PF6–, BF4–, OTf–, ClO4–), stabilized by the new hybrid guanidine ligand 2-(2-((dimethylamino)methyl)phenyl)-1,1,3,3-tetramethylguanidine (L1), and its characterization by UV/Vis, Raman, and XAS spectroscopy, as well as cryo-UHR-ESI mass spectrometry, are described. The highlight selective oxygenation of a plethora of phenolic substrates such as 1H-indol-7-ol, naphthalen-1-ol, pyridin-4-ol, etc. mediated by [O1](PF6)2, results in mono- and bicyclic quinones such as 3,4-pyridinedione, 1,2-naphthalenedione, 1H-indole-6,7-dione and provides an attractive strategy for designing new phenazines e.g., benzo[a]phenazine. The selectivity is predicted by using the Fukui function, which is hereby introduced into tyrosinase model chem. The bioinspired catalysis harnesses mol. dioxygen for organic transformations and achieves a substrate diversity reaching far beyond the scope of the enzyme. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2HPLC of Formula: 626-64-2).
Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.HPLC of Formula: 626-64-2