Comparative evaluation of new dihydropyrimidine and dihydropyridine derivatives perturbing mitotic spindle formation was written by Peruzynska, Magdalena;Piotrowska, Katarzyna;Tkacz, Marta;Kurzawski, Mateusz;Struk, Lukasz;Borzyszkowska, Aleksandra;Idzik, Tomasz J.;Sosnicki, Jacek G.;Drozdzik, Marek. And the article was included in Future Medicinal Chemistry in 2018.Safety of 5-Phenylpyridin-2-ol This article mentions the following:
Aim: The mitotic spindle plays a key role in cell division which makes it an important target in cancer therapy. In the present study the antiproliferative activity of 4-benzyl-5-phenyl-3,4-dihydropyrimidine-2(1H)-thione (1) and its pyridine bioisoster (2) were evaluated and compared with monastrol (MON), the first known cell-permeable small mol. which disrupts bipolar spindle formation by inhibiting Eg5-kinesin activity. Results: Our data revealed that compound 2 showed higher antiproliferative activity than MON against MCF7 and A375 cell lines and comparable reversible cell cycle inhibition in G2/M phase. However, compound 2 produced distinct phenotype from monoastral spindles, and did not affect Eg5 ATPase activity. Conclusion: The activity of compound 2 may suggest its new promising anticancer mechanism (different than MON), targeting other component required for spindle bipolarity. In the experiment, the researchers used many compounds, for example, 5-Phenylpyridin-2-ol (cas: 76053-45-7Safety of 5-Phenylpyridin-2-ol).
5-Phenylpyridin-2-ol (cas: 76053-45-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 5-Phenylpyridin-2-ol