The thermal condensation of imidazoles with carbonyl compounds was written by Roe, A. M.. And the article was included in Journal of the Chemical Society in 1963.Electric Literature of C7H10N2 This article mentions the following:
1-Substituted 2-(1-hydroxy-1-alkyl-and aryl)imidazoles (I) are obtained by thermal condensation of 1-methyl-, 1-benzyl-, and 1-methoxy-methylimidazole with aldehydes. These and other alc. are also obtained from the Li derivativeof the imidazole. 2-Acetylimidazole has been preparedand characterized. 1,4-Diketones react with imidazole to give imidazo[1,2-a]pyridines (II). In the experiment, the researchers used many compounds, for example, 3,6-Dimethyl-2-pyridinamine (cas: 823-61-0Electric Literature of C7H10N2).
3,6-Dimethyl-2-pyridinamine (cas: 823-61-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C7H10N2