2-Oxo-1,8-naphthyridine-3-carboxylic acid derivatives with potent gastric antisecretory properties was written by Santilli, Arthur A.;Scotese, Anthony C.;Bauer, Raymond F.;Bell, Stanley C.. And the article was included in Journal of Medicinal Chemistry in 1987.Name: 2-(Methylamino)nicotinonitrile This article mentions the following:
The syntheses of 2-oxo-1,8-naphthyridine-3-carboxylic acid derivatives, e.g., I (R = H, Me, Et, Pr, allyl, etc.; R1 = NH2, 4-methylpiperazinyl, etc.; R2 = H, Me), having potent gastric antisecretory properties in the Shay rat model are described. Two of the more potent compounds tested that were selected for more detailed dose-response evaluation were I (R = Et, R1 = NH2, R2 = H; II) and I (R = Et, R1 = 4-methylpiperazinyl, R2 = Me; III). II and III lowered total acid output in a dose-related fashion, were more potent than cimetidine, and showed inhibitory activity in food-stimulated acid secretion in the Pavlov dog. The mechanism of action for this series is not known. Details of structure-activity relationships are described. In the experiment, the researchers used many compounds, for example, 2-(Methylamino)nicotinonitrile (cas: 52583-87-6Name: 2-(Methylamino)nicotinonitrile).
2-(Methylamino)nicotinonitrile (cas: 52583-87-6) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Name: 2-(Methylamino)nicotinonitrile