Catalytic cocyclization of acetylene with nitriles in the presence of bis(η2-ethene)(η6-toluene)iron as catalyst was written by Schmidt, U.;Zenneck, U.. And the article was included in Journal of Organometallic Chemistry in 1992.Application of 644-98-4 This article mentions the following:
The reactive arene complex bis(η2-ethene)(η6-toluene)iron co-cyclotrimerizes acetylene and nitriles RCN (R = CH3, C2H5, n-C3H7, i-C3H7, C6H5) catalytically to give pyridine derivatives In the case of acrylonitrile the reaction fails. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Application of 644-98-4).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 644-98-4