The effect of adding Crabtree’s catalyst to rhodium black in direct hydrogen isotope exchange reactions was written by Schou, Soeren Christian. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 2009.Safety of 2-Isopropylpyridine This article mentions the following:
A new catalytic system based on rhodium black using Crabtree’s catalyst as an additive for direct hydrogen isotope exchange in aromatic compounds has been investigated. The level of deuterium incorporation can be improved from for example 16 to 93%. The new catalyst mixture tolerates a variety of solvents. Copyright © 2009 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Safety of 2-Isopropylpyridine).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of 2-Isopropylpyridine