Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 101066-61-9, name is 2-Chloroisonicotinaldehyde. A new synthetic method of this compound is introduced below., HPLC of Formula: C6H4ClNO
To a solution of 2-chloroisonicotinaidehyde (230 mg, 1.60 mmoi) in DCM (3 mL) was added DAST (773 mg, 4,80 rnrnol) at 0C under N2 and the mixture stirred at 0C for lh. Saturated aq. NaHCO3 was added and the mixture extracted with EtOAc (30 rnL x 3). The combined organic layers were dried over MgSO4, filtered, the filtrate concentrated in vacuo and the crude product purified by chromatography on silica (50% EtOAc in petroleum ether) to givethe title compound as an oil. LRMS mlz (M+H) 164.1 found, 164.1 required.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 101066-61-9, 2-Chloroisonicotinaldehyde.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; SKUDLAREK, Jason; (79 pag.)WO2016/95204; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem