Application of 186593-42-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 186593-42-0, name is 3-Bromo-2-methyl-5-nitropyridine. A new synthetic method of this compound is introduced below.
4-(2-Methyl-5-nitropyridin-3-yl)-N-neopentyIbenzenesulfonamide. The compound obtained above (30 mg, 0.085 mmol), 3-bromo-5-nitro-2-methylpyridine (1.0 eq., 18 mg), K2CO3 (3 eq., 35 mg) and Pd(PPh3)4 (10 mol %, 10 mg) were dissolved in 3 ml DMErEtOH (9: 1). The solution was stirred at 800C for 24 hr under nitrogen. The mixture was concentrated in vacuo. Column chromatography (SiOa; 3:1 Hex: EtOAc) yielded 20 mg of the target compound. (CaIc. mass: 364, obs. mass 364).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,186593-42-0, 3-Bromo-2-methyl-5-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; KEMIA, INC.; WO2008/21388; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem