Adding a certain compound to certain chemical reactions, such as: 754214-42-1, 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 754214-42-1, blongs to pyridine-derivatives compound. Product Details of 754214-42-1
A suspension of 1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid (250 mg, 1.5 mmol) in N,N-dimethylformamide (5 mL) was warmed to 40 C. N-chlorosuccinimide (243 mg, 1.62 mmol) was added and the mixture was stirred at 55 C. for 5 hours. The reaction was cooled to room temperature and left stirring for 2 days. The mixture was diluted with water (20 mL) and stirred overnight. The resulting solid was collected by filtration and dried to give the title compound (161 mg, 55%). +ESI (M+H) 197.1; 1H NMR (400 MHz, DMSO-d6, delta): 13.08 (br. s., 1H), 12.39 (br. s., 1H), 8.86 (d, J=1.8 Hz, 1H), 8.40 (d, J=1.2 Hz, 1H), 7.84 (d, J=2.5 Hz, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,754214-42-1, 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Pfizer Inc; US2012/108619; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem